Poliovirus circulation among schoolchildren during the early phase of the 1992-1993 poliomyelitis outbreak in The Netherlands.

Abstract

During the 1992-1993 outbreak of poliomyelitis in The Netherlands, we examined 866 childrenat 7 schools for evidence of infection with the outbreak virus, poliovirus type 3(PV3), to determine the extent of the outbreak and the protection of the herd immunity. Seventy-seven children (8.9%) showed evidence of recent wild-type PV3 infection, as determined by virus isolation and/or poliovirus type-specific IgM assay. Most infected children lived in the same area as the index case patient, attended an orthodox-reformed (OR) primary school, and had not been vaccinated. At the OR school, as many as 22% of children immunized with inactive poliovirus vaccine were found to have evidence of recent infection, which is a significantly lower rate than that among unvaccinated children (59.5%). No evidence of vaccination was seen in 25.5%-43.1% of children at OR schools. Seroprevalence of antibodies against the 3 types of poliovirus suggested that no poliovirus circulation had occurred between the 1978 and 1992-1993 outbreaks.

• Authors: P M Oostvogel, H C Rumke, M A Conyn-Van Spaendonck, H G van der Avoort, J Leeuwenburg, A M van Loon
• Journal: The Journal of infectious diseases (J Infect Dis) Vol. 184 Issue 11 Pg. 1451-5 (Dec 01 2001) ISSN: 0022-1899 [Print] United States
• PMID: 11709788 (Publication Type: Journal Article)

Chemical References

• Antibodies, Viral
• Poliovirus Vaccines

Topics

• Adolescent
• Antibodies, Viral (biosynthesis)
• Child
• Child, Preschool
• Community-Acquired Infections (epidemiology, prevention & control, virology)
• Disease Outbreaks
• Feces (virology)
• Female
• Humans
• Male
• Netherlands (epidemiology)
• Poliomyelitis (epidemiology, prevention & control, virology)
• Poliovirus (immunology, isolation & purification)
• Poliovirus Vaccines
• Schools