A 62-year-old female patient, who was diagnosed with
sigmoid colon cancer with multiple liver
metastases, was admitted to our hospital. She underwent sigmoidectomy with D3
lymph node dissection on January 31, 2000. In addition to that, she received hepatic
intra-arterial infusion of levoforinate (l-LV) 250 mg and
5-fluorouracil (5-FU) 500 mg for combined multiple hepatic
metastases starting on postoperative day 14, and these medications were administered over 48 hours once weekly by infuser pump. The
tumor diminished by 59% 2 months after the start of administration and further diminished at 4 months. PR was achieved.
Cancer metastasis to the cerebellum and
metastasis to the lung were detected at month 9 and month 11, respectively, but the liver metastatic
tumor continued to diminish in size, ultimately becoming undetectable by CT scan at month 10. Surgery and
radiotherapy were performed for the cerebellar
metastasis, and
intravenous administration of a combination of l-LV and
5-FU was performed systemically for the pulmonary metastatic
tumor. At present, the patient receives regular outpatient treatment continuously. To our knowledge, there has been no report on the combination
therapy with l-LV and
5-FU through the hepatic artery. Since good antitumor efficacy was demonstrated in the present patient, this case is described in this report together with four other cases of hepatic
metastasis from
colorectal cancer.