[A case of cervical myeloradiculopathy with positive serum anti-GT1a antibody].

Abstract

A 19-year-old man with cervical myeloradiculopathy is reported. He was admitted to our hospital because of acute muscle weakness of upper limbs, which developed two weeks after respiratory tract infection. Neurologic examination revealed prominent muscular weakness of upper limbs. Deep tendon reflexes showed hyporeflexia in upper limbs and hyperreflexia in lower limbs. Serum IgG anti-GT1a antibody was detected by thin-layer chromatography and immunoblotting. Neck MRI revealed T2-weighted high intensity legions and swelling in spinal cord at third to sixth cervical segment. The muscular weakness and the cervical legion in MRI improved two weeks after steroid treatment. These findings indicate the involvement of cervical pyramidal tract as well as that of cervical roots in the patient. Neurological symptoms of the present case differed from those of pharyngeal-cervical-brachial variant (PCB) of Guillain-Barré syndrome, although serum anti-GT1a antibody was positive.

• Authors: Y Oshima, T Mitsui, H Yoshino, A Hirono, T Matumoto
• Journal: Rinsho shinkeigaku = Clinical neurology (Rinsho Shinkeigaku) 2001 Apr-May Vol. 41 Issue 4-5 Pg. 184-6 ISSN: 0009-918X [Print] Japan
• PMID: 11676159 (Publication Type: Case Reports, English Abstract, Journal Article)

Chemical References

• Autoantibodies
• Biomarkers
• Gangliosides
• Immunoglobulin G
• trisialoganglioside GT1

Topics

• Adult
• Autoantibodies (blood)
• Biomarkers (blood)
• Gangliosides (immunology)
• Humans
• Immunoglobulin G (blood)
• Magnetic Resonance Imaging
• Male
• Polyradiculoneuropathy (diagnosis, immunology, pathology)
• Pyramidal Tracts (pathology)