Abstract | BACKGROUND:
Diabetic nephropathy is a chronic, progressive kidney disease with a mean rate of decline of in glomerular filtration rate (GFR) of 10 to 12 mL/min/year (natural history). The introduction of aggressive antihypertensive treatment has improved the renal prognosis during the last decades. To examine whether remission and regression of diabetic nephropathy are possible in type 1 diabetic patients, we analyzed data from a prospective observational cohort study that was started in 1983. METHODS: RESULTS: The total number of patients who obtained remission was 92 (31%), with a duration of remission of [median (range)] 3.4 (1.0 to 14.1) years, and regression 67 (22%). The patients were stratified in quintiles by the average value of office mean arterial blood pressure (mean +/- SE): 93 +/- 0.5, 99 +/- 0.2, 103 +/- 0.1, 107 +/- 0.2, and 113 +/- 0.4 mm Hg. The prevalence of patients obtaining remission/regression was 58/42, 33/32, 25/11, 20/20, and 17/7% in each quintile, respectively. Spontaneous remission and regression occurred in 10 and 14 patients from the persistent normotensive group ( N = 30), none of whom had ever received antihypertensive treatment. In all 301 consecutive patients, the (mean +/- SE) DeltaGFR was 4.0 +/- 0.2 mL/min/year during the investigation period. CONCLUSIONS:
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Authors | P Hovind, P Rossing, L Tarnow, U M Smidt, H H Parving |
Journal | Kidney international
(Kidney Int)
Vol. 60
Issue 1
Pg. 277-83
(Jul 2001)
ISSN: 0085-2538 [Print] United States |
PMID | 11422762
(Publication Type: Clinical Trial, Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Angiotensin-Converting Enzyme Inhibitors
- Antihypertensive Agents
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Topics |
- Adult
- Albuminuria
(urine)
- Angiotensin-Converting Enzyme Inhibitors
(therapeutic use)
- Antihypertensive Agents
(therapeutic use)
- Cohort Studies
- Diabetes Mellitus, Type 1
(drug therapy)
- Diabetic Nephropathies
(drug therapy, physiopathology)
- Female
- Glomerular Filtration Rate
- Humans
- Longitudinal Studies
- Male
- Middle Aged
- Prospective Studies
- Remission Induction
- Remission, Spontaneous
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