Abstract | OBJECTIVES/HYPOTHESIS: STUDY DESIGN: Retrospective review. METHODS: Patients (age range, 60-92 y) were injected with 1.0 mg/kg PHOTOFRIN (dihematoporphyrin derivative) followed 60 hours later by intraoperative laser light activation. Light was delivered through microlens fiber by means of an argon dye laser at 630 nm at a light dose of 100 to 300 J/cm2 microlens delivery for PDT alone and 50 to 100 J/cm2 microlens delivery for tumor bed resection sites in the case of adjunct PDT combined with surgical resection. RESULTS: Twelve cases of aggressive recurrent nonmelanomatous cutaneous tumors of the head and neck were treated. Five patients received intraoperative PDT combined with surgical resection, including radical mastoidectomy, lateral temporal bone resection, partial maxillectomy with temporalis myofacial flap reconstruction, and wide local resection with secondary intention healing of exposed scalp wounds. Seven patients were treated with PDT alone for extensive multiple cutaneous lesions or wide-field primary or recurrent nonmelanomatous tumors. Ten patients achieved complete responses (follow-up, 6-60 mo) with excellent wound healing and cosmetic outcomes. CONCLUSIONS:
PHOTOFRIN-mediated PDT is an excellent locoregional oncological modality for aggressive primary or recurrent basal cell carcinoma and squamous cell carcinoma, particularly in elderly patients who were previously treated with extensive Mohs microsurgery, surgical resection, and external-beam radiation therapy. Multiple repeat treatments are well tolerated, painless, without systemic morbidity, and amenable to local anesthesia or intravenous sedation for PDT alone, and wound healing and cosmetic outcomes are excellent.
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Authors | V Gayl Schweitzer |
Journal | The Laryngoscope
(Laryngoscope)
Vol. 111
Issue 6
Pg. 1091-8
(Jun 2001)
ISSN: 0023-852X [Print] United States |
PMID | 11404627
(Publication Type: Evaluation Study, Journal Article)
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Chemical References |
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Topics |
- Aged
- Aged, 80 and over
- Bowen's Disease
(drug therapy, pathology)
- Carcinoma, Basal Cell
(drug therapy, pathology)
- Carcinoma, Squamous Cell
(drug therapy, pathology)
- Dihematoporphyrin Ether
- Female
- Head and Neck Neoplasms
(drug therapy, pathology)
- Hematoporphyrin Photoradiation
- Humans
- Male
- Neoplasm Staging
- Retrospective Studies
- Skin Neoplasms
(drug therapy, pathology)
- Treatment Outcome
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