Juvenile xanthogranuloma: case report with immunohistochemical identification of early and late cytomegalovirus antigens.

Abstract

Juvenile xanthogranuloma (JXG) is a dermatological condition of unknown etiology that rarely affects the oral mucosa. There are conflicting reports suggesting that it may represent a reactive virally-induced lesion associated with cytomegalovirus (CMV) infection. The present paper reports an additional case of oral JXG and discusses its possible association with CMV infection. The biotin-streptavidin system was used to detect early and late CMV antigens. Positive immunolabelling for both antigens was demonstrated in some histiocytes in the lesion. These findings suggest that JXG may be associated with CMV infection.

• Authors: F O Vasconcelos, L A Oliveira, M D Naves, W H Castro, R S Gomez
• Journal: Journal of oral science (J Oral Sci) Vol. 43 Issue 1 Pg. 21-5 (Mar 2001) ISSN: 1343-4934 [Print] Japan
• PMID: 11383632 (Publication Type: Case Reports, Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Antigens, CD
• Antigens, Differentiation, Myelomonocytic
• Antigens, Viral
• CD68 antigen, human
• EBV-associated membrane antigen, Epstein-Barr virus
• Receptors, Cell Surface
• Viral Matrix Proteins

Topics

• Antigens, CD (analysis)
• Antigens, Differentiation, Myelomonocytic (analysis)
• Antigens, Viral (analysis)
• Child
• Cytomegalovirus (immunology)
• Cytomegalovirus Infections (diagnosis)
• Female
• Follow-Up Studies
• Giant Cells (virology)
• Histiocytes (immunology, virology)
• Humans
• Immunoenzyme Techniques
• Immunohistochemistry
• Macrophages (virology)
• Mouth Diseases (immunology, virology)
• Receptors, Cell Surface (analysis)
• Viral Matrix Proteins (analysis)
• Xanthogranuloma, Juvenile (immunology, virology)