Abstract | BACKGROUND: METHODS: Hepatic tissue LCAT mRNA and plasma LCAT enzymatic activity were measured in male Sprague-Dawley rats six weeks after excisional 5/6 nephrectomy or sham operation. RESULTS: Compared with the controls, the CRF group exhibited a significant reduction of hepatic tissue LCAT mRNA abundance. The reduction in hepatic LCAT mRNA was accompanied by a marked reduction of plasma LCAT activity and elevation of serum-free cholesterol in the CRF animals. LCAT activity correlated positively with the HDL/total cholesterol ratio and inversely with free cholesterol and triglyceride concentrations. CONCLUSIONS:
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Authors | N D Vaziri, K Liang, J S Parks |
Journal | Kidney international
(Kidney Int)
Vol. 59
Issue 6
Pg. 2192-6
(Jun 2001)
ISSN: 0085-2538 [Print] United States |
PMID | 11380821
(Publication Type: Journal Article, Research Support, U.S. Gov't, P.H.S.)
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Chemical References |
- Lipoproteins, HDL
- RNA, Messenger
- Triglycerides
- Cholesterol
- Creatinine
- Phosphatidylcholine-Sterol O-Acyltransferase
|
Topics |
- Animals
- Blotting, Northern
- Cardiovascular Diseases
(metabolism)
- Cholesterol
(blood)
- Creatinine
(blood)
- Gene Expression Regulation, Enzymologic
- Hypertriglyceridemia
(metabolism)
- Kidney Failure, Chronic
(metabolism)
- Lipoproteins, HDL
(blood)
- Liver
(enzymology)
- Male
- Phosphatidylcholine-Sterol O-Acyltransferase
(blood, genetics)
- RNA, Messenger
(analysis)
- Rats
- Rats, Sprague-Dawley
- Triglycerides
(blood)
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