Abstract | PURPOSE: EXPERIMENTAL DESIGN: Patients entered a high-dose chemotherapy protocol in which the first high-dose cycle was paclitaxel at 825 mg/m(2) given over 24 h. The first cohort of patients did not receive glutamine, and the second cohort of patients received glutamine at 10 g orally three times a day for 4 days starting 24 h after completion of paclitaxel. Neurological assessment was performed at baseline, and at least 2 weeks after paclitaxel, and consisted of a complete neurological exam and nerve conduction studies. RESULTS: There were paired pre- and post- paclitaxel evaluations on 33 patients who did not receive glutamine and 12 patients who did. The median interval between pre- and post-exams was 32 days. For patients who received glutamine, there was a statistically significant reduction in the severity of peripheral neuropathy as measured by development of moderate to severe dysesthesias and numbness in the fingers and toes (P < 0.05). The degree and incidence of motor weakness was reduced (56 versus 25%; P = 0.04) as well as deterioration in gait (85 versus 45%; P = 0.016) and interference with activities of daily living (85 versus 27%; P = 0.001). Moderate to severe paresthesias in the fingers and toes were also reduced (55 versus 42% and 64 versus 50%, respectively), although this value was not statistically significant. All of these toxicities were reversible over time. CONCLUSIONS:
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Authors | L Vahdat, K Papadopoulos, D Lange, S Leuin, E Kaufman, D Donovan, D Frederick, E Bagiella, A Tiersten, G Nichols, T Garrett, D Savage, K Antman, C S Hesdorffer, C Balmaceda |
Journal | Clinical cancer research : an official journal of the American Association for Cancer Research
(Clin Cancer Res)
Vol. 7
Issue 5
Pg. 1192-7
(May 2001)
ISSN: 1078-0432 [Print] United States |
PMID | 11350883
(Publication Type: Clinical Trial, Journal Article, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, P.H.S.)
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Chemical References |
- Antineoplastic Agents, Phytogenic
- Glutamine
- Paclitaxel
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Topics |
- Activities of Daily Living
- Administration, Oral
- Antineoplastic Agents, Phytogenic
(administration & dosage, adverse effects)
- Female
- Glutamine
(therapeutic use)
- Humans
- Neural Conduction
(drug effects)
- Paclitaxel
(administration & dosage, adverse effects)
- Peripheral Nervous System Diseases
(chemically induced, drug therapy, physiopathology)
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