Hyponatremia and polyuria in children with central diabetes insipidus: challenges in diagnosis and management.

Abstract

Five patients with well-controlled, long-standing, central diabetes insipidus had acute development of dehydration, hyponatremia, and inappropriate natriuresis in the setting of polyuria resistant to exogenous antidiuretic hormone. Hyponatremia and dehydration worsened with fluid restriction or use of exogenous antidiuretic hormone. We discuss the challenges in diagnosis and management of probable salt wasting in children with central diabetes insipidus.

• Authors: R J Ferry Jr, V Kesavulu, A Kelly, L E Levitt Katz, T Moshang Jr
• Journal: The Journal of pediatrics (J Pediatr) Vol. 138 Issue 5 Pg. 744-7 (May 2001) ISSN: 0022-3476 [Print] United States
• PMID: 11343054 (Publication Type: Case Reports, Journal Article, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, P.H.S.)

Chemical References

• Vasopressins
• Sodium Chloride

Topics

• Adolescent
• Adult
• Child
• Child, Preschool
• Diabetes Insipidus, Neurogenic (complications, diagnosis, therapy)
• Female
• Humans
• Hyponatremia (etiology)
• Male
• Polyuria (etiology)
• Sodium Chloride (therapeutic use)
• Vasopressins (adverse effects, therapeutic use)