Pharmacokinetics of enrofloxacin and its metabolite ciprofloxacin after intramuscular administration of enrofloxacin in goats.

Abstract

The pharmacokinetics of enrofloxacin and its active metabolite ciprofloxacin were investigated in goats after a single intramuscular administration of enrofloxacin at 2.5 mg/kg body weight. The plasma concentrations of enrofloxacin and ciprofloxacin were determined simultaneously by a HPLC method. The peak concentrations (Cmax) of enrofloxacin (1.13 microg/ml) and ciprofloxacin (0.24 microg/ml) were observed at 0.8 and 1.2 h, respectively. The elimination half-life (t1/2beta), volume of distribution (Vd(area)), total body clearance (Cl(B)) and mean residence time (MRT) of enrofloxacin were 0.74 h, 1.42 L/kg, 1329 ml/h per kg and 1.54 h, respectively. The t1/2beta, area under the plasma concentration-time curve (AUC) and the MRT of ciprofloxacin were 1.38 h, 0.74 microg h/ml and 2.73 h, respectively. The metabolic conversion of enrofloxacin to ciprofloxacin was appreciable (36%) and the sum of the plasma concentrations of enrofloxacin and ciprofloxacin was maintained at or above 0.1 microg/ml for up to 4 h. Enrofloxacin appears to be useful for the treatment of goat diseases associated with pathogens sensitive to this drug.

• Authors: G S Rao, S Ramesh, A H Ahmad, H C Tripathi, L D Sharma, J K Malik
• Journal: Veterinary research communications (Vet Res Commun) Vol. 25 Issue 3 Pg. 197-204 (Apr 2001) ISSN: 0165-7380 [Print] Netherlands
• PMID: 11334149 (Publication Type: Journal Article)

Chemical References

• Anti-Infective Agents
• Fluoroquinolones
• Quinolones
• Enrofloxacin
• Ciprofloxacin

Topics

• Animals
• Anti-Infective Agents (blood, pharmacokinetics)
• Area Under Curve
• Ciprofloxacin (blood, pharmacokinetics)
• Enrofloxacin
• Female
• Fluoroquinolones
• Goats (blood, metabolism)
• Half-Life
• Injections, Intramuscular (veterinary)
• Quinolones (blood, pharmacokinetics)