Abstract | BACKGROUND: METHODS: In 3 groups of 10 rats each, ischemia was induced by elevating the intraocular pressure of the left eye to 120 mmHg for 1 h. Saline, gabapentin (2 x 50 mg/kg intraperitoneally) and GBP-L (2 x 50 mg/kg intraperitoneally) were injected before and 5 h after ischemia. Two weeks later ischemic damage was quantified histologically by counting the number of neurons in the ganglion cell layer. In vitro transmitter release experiments were performed to obtain information on the effect of gabapentin and GBP-L on ischemia-induced glutamate release and the mechanism of action of GBP-L. RESULTS: CONCLUSION:
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Authors | T Jehle, T J Feuerstein, W A Lagrèze |
Journal | Der Ophthalmologe : Zeitschrift der Deutschen Ophthalmologischen Gesellschaft
(Ophthalmologe)
Vol. 98
Issue 3
Pg. 237-41
(Mar 2001)
ISSN: 0941-293X [Print] Germany |
Vernacular Title | Der Effekt von Gabapentin und Gabapentin-Laktam auf das Uberleben retinaler Ganglienzellen. Situation nach akuter retinaler Ischämie im Tiermodell. |
PMID | 11320809
(Publication Type: Comparative Study, Journal Article)
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Chemical References |
- Acetates
- Amines
- Anticonvulsants
- Aza Compounds
- Convulsants
- Cyclohexanecarboxylic Acids
- Glutamates
- Neuroprotective Agents
- Receptors, Glutamate
- Spiro Compounds
- gabapentin-lactam
- gamma-Aminobutyric Acid
- Gabapentin
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Topics |
- Acetates
(administration & dosage, pharmacology)
- Amines
- Animals
- Anticonvulsants
(administration & dosage, pharmacology)
- Aza Compounds
(administration & dosage, pharmacology)
- Cell Survival
(drug effects)
- Convulsants
(administration & dosage, pharmacology)
- Cyclohexanecarboxylic Acids
- Disease Models, Animal
- Gabapentin
- Glutamates
(metabolism)
- In Vitro Techniques
- Ischemia
(drug therapy, metabolism)
- Male
- Neuroprotective Agents
(pharmacology)
- Rats
- Rats, Sprague-Dawley
- Receptors, Glutamate
(drug effects)
- Retinal Diseases
(drug therapy, metabolism)
- Retinal Ganglion Cells
(drug effects)
- Retinal Vessels
(drug effects, metabolism)
- Spiro Compounds
(administration & dosage, pharmacology)
- Time Factors
- gamma-Aminobutyric Acid
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