Interleukin 12 and autoimmune diabetes.

Abstract

Interleukin 12 (IL-12) has been implicated in the pathogenesis of type 1 diabetes in the non-obese diabetic (NOD) mouse. Following this lead, a new locus associated with human type 1 diabetes, IDDM18, has been identified near the gene encoding the p40 subunit of interleukin 12 (IL12B). This finding has potential implications for the prediction of at-risk individuals and, perhaps, for the implementation of prevention strategies relevant to several autoimmune diseases.

• Authors: L Adorini
• Journal: Nature genetics (Nat Genet) Vol. 27 Issue 2 Pg. 131-2 (Feb 2001) ISSN: 1061-4036 [Print] United States
• PMID: 11175771 (Publication Type: Comment, Journal Article)

Chemical References

• Interleukin-12

Topics

• Animals
• Autoimmune Diseases (genetics)
• Diabetes Mellitus, Type 1 (etiology, genetics, immunology)
• Genetic Predisposition to Disease
• Humans
• Interleukin-12 (genetics)
• Mice
• Mice, Inbred NOD
• Models, Immunological