Targeting and anti-tumor efficacy of liposomal 5'-O-dipalmitoylphosphatidyl 2'-C-cyano-2'-deoxy-1-beta-D-arabino-pentofuranosylcytosine in mice lung bearing B16BL6 melanoma.

Abstract

2'-C-cyano-2'-deoxy-1-beta-D-arabino-pentofuranosylcytosine (CNDAC) is a potent anti-cancer agent, and we previously observed that liposomal formulation of 5'-O-dipalmitoylphosphatidyl derivative of CNDAC (DPP-CNDAC) is desirable for targeting. For targeting to pulmonary cancer, we investigated the in vivo behavior of liposomes containing DPP-CNDAC by a non-invasive method using positron emission tomography. Liposomes composed of DPP-CNDAC and cholesterol (DPP-CNDAC/CH liposomes) were markedly accumulated in mice lung bearing B16BL6 melanoma. In metastatic pulmonary cancer model, DPP-CNDAC/CH liposomes significantly reduced the lung colonization in a dose-dependent manner. The activity was significantly superior to conventional liposomal formulation or soluble CNDAC. These results suggest that DPP-CNDAC/CH liposomes are useful for metastatic pulmonary cancer.

• Authors: T Asai, S Shuto, A Matsuda, T Kakiuchi, H Ohba, H Tsukada, N Oku
• Journal: Cancer letters (Cancer Lett) Vol. 162 Issue 1 Pg. 49-56 (Jan 10 2001) ISSN: 0304-3835 [Print] Ireland
• PMID: 11121862 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Antineoplastic Agents
• Liposomes
• Cytarabine
• 2'-cyano-2'-deoxyarabinofuranosylcytosine

Topics

• Animals
• Antineoplastic Agents (administration & dosage)
• Cytarabine (administration & dosage, analogs & derivatives)
• Liposomes
• Lung Neoplasms (diagnostic imaging, drug therapy)
• Male
• Melanoma, Experimental (diagnostic imaging, drug therapy)
• Mice
• Mice, Inbred C57BL
• Tomography, Emission-Computed