[Effectiveness of dietary non-starch polysaccharides in experimental toxic hepatitis].

Abstract

The efficiency of some polysaccharides was investigated in mice with an experimental toxic hepatitis. Hepatitis was induced by the oral administration of 10% solution CCl4 in olive oil at a dosage of 3 ml/kg body weight every day during 7 days. After that tested substances were administrated every day 30-40 min before a feeding at a dosage of 150 mg/kg body weight during 14-21 days. Results showed that a calcium alginate, two low-methoxyl pectins (one with the degree of esterification about 50% and other with the degree of esterification less 5%), fucoidan, and chitozan, but not lambda-carrageenan and kappa-carrageenan, have beneficial affects on liver total lipid, glycogen, malondialdehyde, and diene conjugates as well as on blood total lipid and alanine aminotransferase activity in animals with experimental toxic hepatitis.

• Authors: Iu S Khotimchenko, E I Khasina, V V Kovalev, O I Shevtsova, S V Shestakova
• Journal: Voprosy pitaniia (Vopr Pitan) Vol. 69 Issue 1-2 Pg. 22-6 ( 2000) ISSN: 0042-8833 [Print] Russia (Federation)
• Vernacular Title: Effektivnost' pishchevykh nekrakhmal'nykh polisakharidov pri éksperimental'nom toksicheskom gepatite.
• PMID: 10943000 (Publication Type: Comparative Study, Journal Article)

Chemical References

• Dietary Carbohydrates
• Lipids
• Polysaccharides
• Chitin
• Carrageenan
• Chitosan
• fucoidan
• Alanine Transaminase

Topics

• Alanine Transaminase (metabolism)
• Animals
• Carbon Tetrachloride Poisoning (complications)
• Carrageenan (administration & dosage, pharmacology)
• Chemical and Drug Induced Liver Injury (diet therapy, etiology, metabolism)
• Chitin (administration & dosage, analogs & derivatives, pharmacology)
• Chitosan
• Dietary Carbohydrates (administration & dosage, pharmacology)
• Hepatitis, Animal (chemically induced, diet therapy, metabolism)
• Lipid Metabolism
• Lipids (blood)
• Liver (drug effects, metabolism)
• Male
• Mice
• Polysaccharides (administration & dosage, pharmacology)
• Time Factors