Abstract | OBJECTIVES: PATIENTS AND METHODS: CA-125 was measured in serial weekly samples selected from diagnostic groups of patients with trophoblastic disease. Sixteen patients had hydatidiform mole with spontaneous resolution, fourteen had nonmetastatic gestational trophoblastic tumor, and four had low-risk metastatic disease. Six patients had high-risk metastatic disease. Ten patients had partial hydatidiform mole and one of these required chemotherapy. One patient had primary ovarian choriocarcinoma and three had placental site tumor. RESULTS: The mean preevacuation CA-125 among the 15 patients with complete hydatidiform mole was 40.9 U/ml: 52.5 U/ml for 5 patients who required chemotherapy and 36.2 U/ml for 10 patients who did not require chemotherapy. There was no statistical difference between these values. There was no correlation of CA-125 with hCG. Frequently CA-125 became negative when hCG was still elevated. Among six patients with high-risk disease, CA-125 was elevated in four but in all six patients hCG remained elevated when CA-125 became negative. In nine patients with partial hydatidiform mole CA-125 was elevated prior to mole evacuation and then became negative. The patient with a tetraploid conceptus who required chemotherapy had negative CA-125. With placental site tumor CA-125 was negative, but it was elevated with ovarian choriocarcinoma. CONCLUSION:
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Authors | E I Kohorn |
Journal | Gynecologic oncology
(Gynecol Oncol)
Vol. 78
Issue 1
Pg. 39-42
(Jul 2000)
ISSN: 0090-8258 [Print] United States |
PMID | 10873407
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Copyright | Copyright 2000 Academic Press. |
Chemical References |
- Biomarkers, Tumor
- CA-125 Antigen
- Chorionic Gonadotropin
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Topics |
- Adult
- Antineoplastic Combined Chemotherapy Protocols
(therapeutic use)
- Biomarkers, Tumor
(analysis)
- CA-125 Antigen
(analysis)
- Chorionic Gonadotropin
(analysis)
- False Negative Reactions
- Female
- Humans
- Hydatidiform Mole
(drug therapy, immunology, pathology)
- Predictive Value of Tests
- Pregnancy
- Reproducibility of Results
- Uterine Neoplasms
(drug therapy, immunology, pathology)
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