[Intraperitoneal cisplatin plus epinephrine and surgical debulking for the treatment of advanced peritoneal carcinomatosis in the rat].

Abstract

OBJECTIVE:

To evaluate and compare the effects of cytoreductive surgery with intraperitoneal cisplatin and epinephrine on peritoneal carcinomatosis in the rat.

MATERIAL AND METHODS:

Twenty-day old peritoneal carcinomatosis was obtained after intraperitoneal injection of 1 x 10(6) DHD/K12/PROb cells into BDIX rats. The surgical treatment included electric fulguration of the peritoneal tumors with spleen and omentum removal while intraperitoneal chemotherapy included platinum (3 mg/kg) associated with epinephrine (2 mg/kg).

RESULTS:

Surgery did not increase rat survival unlike cisplatin or cisplatin/epinephrine chemotherapy. Intraperitoneal chemotherapy alone with cisplatin +/- epinephrine increased survival but did not provide cure. Surgery followed by intraperitoneal cisplatin and epinephrine cured four out of five twenty-day old peritoneal carcinomatosis.

CONCLUSION:

Surgery combined with intraperitoneal cisplatin and epinephrine could be an efficient treatment for peritoneal carcinomatosis in man.

• Authors: L Benoit, C Duvillard, J L Beltramo, P Brunet-Lecomte, B Chauffert
• Journal: Gastroenterologie clinique et biologique (Gastroenterol Clin Biol) Vol. 24 Issue 1 Pg. 26-30 (Jan 2000) ISSN: 0399-8320 [Print] France
• Vernacular Title: Optimisation du traitement des carcinoses péritonéales évoluées par la réduction tumorale chirurgicale et l'association cisplatine-adrénaline chez le rat.
• PMID: 10679584 (Publication Type: English Abstract, Journal Article)

Chemical References

• Antineoplastic Agents
• Vasoconstrictor Agents
• Cisplatin
• Epinephrine

Topics

• Animals
• Antineoplastic Agents (therapeutic use)
• Carcinoma (drug therapy, surgery)
• Cisplatin (therapeutic use)
• Combined Modality Therapy
• Epinephrine (therapeutic use)
• Female
• Male
• Neoplasm Staging
• Peritoneal Neoplasms (drug therapy, pathology, surgery)
• Rats
• Rats, Inbred Strains
• Vasoconstrictor Agents (therapeutic use)