Abstract |
Polyvinyl chloride ( PVC) is an important plastic resin for construction, pipe and tubing, siding, and other uses. Exposures to vinyl chloride monomer during the early years of production resulted in an important sentinel health event: the recognition of an excess of a rare liver cancer, hepatic angiosarcoma, at facilities throughout the world. Several other syndromes, including acro-osteolysis, also have been associated with PVC, but less clearly with vinyl chloride. Extensive research ranging from large-scale epidemiologic studies to biomarker research into molecular mechanisms continues to provide valuable insight into the pathogenesis of occupational cancer.
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Authors | R Lewis |
Journal | Occupational medicine (Philadelphia, Pa.)
(Occup Med)
1999 Oct-Dec
Vol. 14
Issue 4
Pg. 719-42
ISSN: 0885-114X [Print] United States |
PMID | 10495482
(Publication Type: Journal Article, Review)
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Chemical References |
- Polyvinyl Chloride
- Vinyl Chloride
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Topics |
- Hemangiosarcoma
(chemically induced, pathology, physiopathology)
- Humans
- Liver Neoplasms
(chemically induced, pathology, physiopathology)
- Occupational Diseases
(chemically induced)
- Occupational Exposure
- Polyvinyl Chloride
(adverse effects)
- Vinyl Chloride
(adverse effects)
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