Plasma amyloid beta-peptide 1-42 and incipient Alzheimer's disease.

Abstract

Mutations in the amyloid precursor protein and presenilin 1 and 2 genes result in elevated plasma levels of the amyloid beta-peptide species terminating at amino acid residue 42 (A beta1-42). In a longitudinal study of unrelated elderly individuals, those who subsequently developed Alzheimer's disease had higher plasma levels of A beta1-42 at entry than did those who remained free of dementia. The results indicate that elevated plasma levels of the released A beta peptide A beta1-42 may be detected several years before the onset of symptoms, supporting that extracellular A beta1-42 plays an important role in the pathogenesis of late-onset Alzheimer's disease.

• Authors: R Mayeux, M X Tang, D M Jacobs, J Manly, K Bell, C Merchant, S A Small, Y Stern, H M Wisniewski, P D Mehta
• Journal: Annals of neurology (Ann Neurol) Vol. 46 Issue 3 Pg. 412-6 (Sep 1999) ISSN: 0364-5134 [Print] United States
• PMID: 10482274 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, P.H.S.)

Chemical References

• Amyloid beta-Peptides
• Peptide Fragments
• amyloid beta-protein (1-43)

Topics

• Age of Onset
• Aged
• Aged, 80 and over
• Alzheimer Disease (blood)
• Amyloid beta-Peptides (blood)
• Female
• Humans
• Male
• Odds Ratio
• Peptide Fragments (blood)