Combined malignant hemangiopericytoma and deep venous thrombosis. A case report.

Abstract

Malignancies, antiproliferative drug treatment, cancer-related conditions like immobilization, perioperative status and radiotherapy are risk factors for hypercoagulability. Setting aside mass or invasion-related venous thrombosis, the differential diagnosis regarding the etiopathogenesis (paraneoplastic syndrome or antiproliferative treatment) is usually problematic. The authors report a case of combined malignant hemangiopericytoma and recurrent deep venous thrombosis in the right inferior limb. Through a literature review, the following issues are discussed: 1) the criteria for cyto-histopathologic assessment; 2) the involvement of pericytes both in coagulation and platelet aggregation; 3) the importance of discriminating true paraneoplastic syndromes from other tumor-related clinical manifestations; 4) the response to external radiotherapy of malignant hemangiopericytoma as limited disease; 5) the poor results of doxorubicin-ifosfamide polychemotherapy and dacarbazine monochemotherapy in metastatic disease. Although doxorubicin-ifosfamide treatment was in progress in the reported case, the authors conclude that the recurrent deep venous thrombosis is likely to be paraneoplastic, even if such a diagnosis has not been previously reported in the literature.

• Authors: N Campanella, M Ferretti, W Daher, M Pergolini, M De Nictolis
• Journal: Tumori (Tumori) 1999 May-Jun Vol. 85 Issue 3 Pg. 199-204 ISSN: 0300-8916 [Print] United States
• PMID: 10426132 (Publication Type: Case Reports, Journal Article, Review)

Topics

• Diagnosis, Differential
• Hemangiopericytoma (complications, diagnosis)
• Humans
• Leg
• Male
• Middle Aged
• Paraneoplastic Syndromes (complications, diagnosis)
• Risk Factors
• Thrombophilia (complications, diagnosis)
• Tomography, X-Ray Computed
• Venous Thrombosis (complications, diagnosis)