Secretory villous adenomas that cause depletion syndrome.

Abstract

Secretory villous adenomas of the colon have been known to cause a depleting syndrome characterized by dehydration, prerenal azotemia, hyponatremia, hypokalemia, metabolic acidosis, obtundation, and, in severe cases, death. We describe 1 case of classic depleting syndrome and review the literature on possible mechanisms. Both cyclic adenosine monophosphate and prostaglandin E2 have been implicated as possible secretagogue compounds in the pathogenesis of this syndrome unique to the secretory variant form of villous adenomas. Indomethacin as a prostaglandin inhibitor has been used with apparent benefit in controlling the volume of rectal effluent in patients with secretory villous adenomas.

• Authors: J Older, P Older, J Colker, R Brown
• Journal: Archives of internal medicine (Arch Intern Med) Vol. 159 Issue 8 Pg. 879-80 (Apr 26 1999) ISSN: 0003-9926 [Print] United States
• PMID: 10219936 (Publication Type: Case Reports, Journal Article)

Topics

• Adenoma, Villous (complications, diagnosis, surgery)
• Adult
• Diagnosis, Differential
• Diarrhea (etiology)
• Humans
• Male
• Rectal Neoplasms (complications, diagnosis, surgery)
• Syndrome
• Water-Electrolyte Imbalance (etiology)