28-deacetylbelamcandal, a tumor-promoting triterpenoid from Iris tectorum.

Abstract

A spiroiridal-type triterpenoid, 28-deacetylbelamcandal (1), was isolated from the rhizomes of Iris tectorum as an active principle that stimulated differentiation of human promyelocytic leukemia (HL-60) cells, a short-term screening method for 12-O-tetradecanoylphorbol 13-acetate (TPA)-type tumor promoters. In the same manner as TPA, compound 1 bound to protein kinase C (PKC) and activated PKC, and induced tumor necrosis factor-alpha release from HL-60 cells. In an in vivo study, groups treated with 100 microg 7, 12-dimethylbenz[a]anthracene plus 400 nmol of 1 showed 64.3% tumor incidence by week 20. It has thus been demonstrated that 1 represents a new structural class of mouse skin-tumor promoters.

• Authors: K Takahashi, Y Hano, M Suganuma, S Okabe, T Nomura
• Journal: Journal of natural products (J Nat Prod) Vol. 62 Issue 2 Pg. 291-3 (Feb 1999) ISSN: 0163-3864 [Print] United States
• PMID: 10075762 (Publication Type: Journal Article)

Chemical References

• 28-deacetylbelamcandal
• Carcinogens
• Triterpenes
• Tumor Necrosis Factor-alpha
• Protein Kinase C

Topics

• Animals
• Carcinogens (isolation & purification, metabolism, pharmacology)
• Cell Adhesion
• Female
• HL-60 Cells
• Humans
• Mice
• Plants (chemistry)
• Protein Binding
• Protein Kinase C (metabolism)
• Skin (drug effects, metabolism)
• Skin Neoplasms (chemically induced)
• Triterpenes (isolation & purification, metabolism, pharmacology)
• Tumor Necrosis Factor-alpha (metabolism)