Abstract |
Occurrence of mucinous tumors is favored by Peutz-Jeghers syndrome (PJS). A case of bilateral ovarian mucinous tumor associated with ovarian mature teratoma occurring in a 22-year-old woman with PJS was reported. Tumor cells included 5 cell types: tall columnar mucinous pale cells with neutral mucins; goblet cells with acidic nonsulfated mucins; non mucinous columnar cells; mucinous cuboidal cells lining small glands; endocrine cells. Expression of the MUC2, MUC3, MUC5AC and MUC6 genes was demonstrated by in situ hybridization according to cell type. Some atypia and numerous mitotic figures were observed in basal glands. Diagnosis was ovarian borderline mucinous tumor with gastric and intestinal phenotype associated with PJS.
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Authors | A Wacrenier, F Boman, M O Farine, M Durand-Reville, M P Buisine, N Porchet, J P Aubert, D Querleu, B Gosselin |
Journal | Annales de pathologie
(Ann Pathol)
Vol. 18
Issue 6
Pg. 497-501
(Dec 1998)
ISSN: 0242-6498 [Print] France |
Vernacular Title | Tumeur mucineuse ovarienne de type gastrique et intestinal associée au syndrome de Peutz-Jeghers; étude en hybridation in situ des transcrits des gènes d'apomucines. |
PMID | 10051919
(Publication Type: Case Reports, English Abstract, Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Biomarkers, Tumor
- MUC2 protein, human
- MUC5AC protein, human
- MUC6 protein, human
- Mucin 5AC
- Mucin-2
- Mucin-3
- Mucin-6
- Mucins
- RNA, Messenger
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Topics |
- Adenocarcinoma, Mucinous
(complications, genetics, pathology)
- Adult
- Biomarkers, Tumor
- Female
- Humans
- In Situ Hybridization
- Intestinal Neoplasms
- Mucin 5AC
- Mucin-2
- Mucin-3
- Mucin-6
- Mucins
(genetics)
- Ovarian Neoplasms
(complications, genetics, pathology)
- Peutz-Jeghers Syndrome
(complications)
- RNA, Messenger
(analysis)
- Stomach Neoplasms
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