Benign Paroxysmal Positional Vertigo

Idiopathic recurrent VERTIGO associated with POSITIONAL NYSTAGMUS. It is associated with a vestibular loss without other neurological or auditory signs. Unlike in LABYRINTHITIS and VESTIBULAR NEURONITIS, inflammation in the ear is not observed.

Also Known As:

Familial Benign Recurrent Vertigo; Familial Vestibulopathy; Vertigo, Benign Paroxysmal Positional; Vertigo, Benign Recurrent; Vestibulopathy, Familial; Benign Recurrent Vertigos; Familial Vestibulopathies; Recurrent Vertigo, Benign; Recurrent Vertigos, Benign; Vestibulopathies, Familial; Benign Recurrent Vertigo

Networked: 302 relevant articles (22 outcomes, 69 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1.	Dizziness (Lightheadedness)
2.	Vertigo (Positional Vertigo)
3.	Meniere Disease (Menieres Disease)
4.	Vestibular Neuronitis (Vestibular Neuritis)
5.	Post-Concussion Syndrome

Experts

1.	Zhou, Min: 6 articles (01/2022 - 01/2018)
2.	Jeong, Seong-Hae: 5 articles (02/2022 - 08/2012)
3.	Kim, Ji-Soo: 5 articles (02/2022 - 03/2013)
4.	Fan, Zhenyi: 5 articles (01/2022 - 01/2018)
5.	Han, Weiwei: 5 articles (01/2022 - 01/2018)
6.	Li, Li: 5 articles (01/2022 - 01/2018)
7.	Lu, Xiaoxiong: 5 articles (01/2022 - 01/2018)
8.	Wu, Yunqin: 5 articles (01/2022 - 01/2018)
9.	Yan, Wang: 5 articles (01/2022 - 01/2018)
10.	Rhim, Gu Il: 4 articles (01/2022 - 12/2016)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Benign Paroxysmal Positional Vertigo:

1.	Betahistine (Serc)IBA 03/31/2023 - "To evaluate the efficacy of Epley's maneuver plus betahistine in the management of patients with posterior canal benign paroxysmal positional vertigo (PC-BPPV). " 06/01/2008 - "To determine the efficacy of a home-based exercise program by comparing it with betahistine in patients with benign paroxysmal positional vertigo (BPPV). " 06/01/2008 - "Efficacy of a home-based exercise program on benign paroxysmal positional vertigo compared with betahistine." 06/21/2016 - "One study, at high risk of bias, included 72 people with benign paroxysmal positional vertigo (BPPV) and compared betahistine with placebo; all patients also had particle repositioning manoeuvres. " 01/01/2012 - "The purpose of this study is to evaluate the effects of betahistine in addition to Epley maneuver on the quality of life of patients with posterior semicircular canal benign paroxysmal positional vertigo (BPPV) of the canalithiasis type. "
2.	Hypnotics and Sedatives (Sedatives)IBA 08/01/2012 - "To compare the efficacy of Epley's manoeuvre and Epley's manoeuvre plus labyrinthine sedative in the treatment of benign paroxysmal positional vertigo. " 06/01/2011 - "To compare the efficacy of Epley's manoeuvre versus Epley's manoeuvre plus labyrinthine sedative in the treatment of benign paroxysmal positional vertigo. " 08/01/2012 - "[Epley's manoeuvre versus Epley's manoeuvre plus labyrinthine sedative in the management of benign paroxysmal positional vertigo: prospective, randomised study]." 06/01/2011 - "We report a prospective, randomised study of 51 patients with benign paroxysmal positional vertigo treated with Epley's manoeuvre alone or Epley's manoeuvre plus labyrinthine sedative, at Sundaram Medical Foundation, Chennai, India. " 06/01/2011 - "Epley's manoeuvre versus Epley's manoeuvre plus labyrinthine sedative as management of benign paroxysmal positional vertigo: prospective, randomised study."
3.	salicylhydroxamic acid (SHAM)IBA 01/01/2014 - "We evaluated the short-term efficacy of Epley, Semont, and sham maneuvers for resolving posterior canal benign paroxysmal positional vertigo (BPPV) in a prospective multicenter randomized double-blind controlled study. " 05/01/2017 - "To determine the immediate and short-term efficacies of mastoid oscillation vs. Gufoni maneuver in treating the apogeotropic type of horizontal canal benign paroxysmal positional vertigo (HC-BPPV), we designed a randomized, prospective, sham-controlled study. " 05/21/2014 - "All patients attending these two primary care centers, who are newly diagnosed with benign paroxysmal positional vertigo, will be invited to participate in the study and will be randomly assigned either to the treatment group (Epley's maneuver) or to the control group (a sham maneuver). " 02/01/2014 - "A randomised sham-controlled trial to assess the long-term effect of the Epley manoeuvre for treatment of posterior canal benign paroxysmal positional vertigo." 08/14/2012 - "To determine the immediate and long-term therapeutic efficacies of barbecue rotation and Gufoni maneuvers, a randomized, prospective, and sham-controlled study was conducted in patients with the geotropic type of benign paroxysmal positional vertigo involving the horizontal semicircular canal (HC-BPPV). "
4.	CalciumIBA 10/01/2016 - "Calcium Homeostasis During Attack and Remission in Patients With Idiopathic Benign Paroxysmal Positional Vertigo." 01/01/2019 - "BACKGROUND The aim of this study was to investigate the correlations of calcium voltage-gated channel subunit alpha1 A (CACNA1A) gene polymorphisms with benign paroxysmal positional vertigo (BPPV). " 01/01/2017 - "Several studies have suggested a possible relationship between recurrent benign paroxysmal positional vertigo (BPPV) and altered calcium homeostasis in the endolymph of the inner ear. " 11/01/2021 - "The association between benign paroxysmal positional vertigo (BPPV) and impaired calcium metabolism has attracted widespread interest. " 11/01/2020 - "We hypothesize that PHPT, the epitome calcium disorder, can cause otoconia degeneration, one manifestation of which is benign paroxysmal positional vertigo (BPPV). "
5.	Trimetazidine (Vastarel)IBA 01/01/2015 - "The aim of this study was to investigate the efficacy of trimetazidine, betahistine, and ginkgo biloba extract in the treatment of residual dizziness after successful repositioning maneuvers for benign paroxysmal positional vertigo. "
6.	FlunarizineIBA 05/01/2004 - "The objective of the study was to evaluate the efficacy of three therapeutic strategies (Semont maneuver, flunarizine, and no treatment) in patients with benign paroxysmal positional vertigo. "
7.	Ginkgo biloba extract (Rokan)IBA 01/01/2015 - "The aim of this study was to investigate the efficacy of trimetazidine, betahistine, and ginkgo biloba extract in the treatment of residual dizziness after successful repositioning maneuvers for benign paroxysmal positional vertigo. "
8.	Anti-Bacterial Agents (Antibiotics)IBA 11/08/2019 - "The otology/neurotology subspecialty group within the Canadian Society of Otolaryngology - Head & Neck Society developed a list of five common otologic presentations to help physicians deliver high quality effective care: (1) Don't order specialized audiometric and vestibular testing to screen for peripheral vestibular disease, (2) Don't perform computed tomography or blood work in the evaluation of sudden sensorineural hearing loss, (3) Don't perform auditory brain responses (ABR) in patients with asymmetrical hearing loss, (4) Don't prescribe oral antibiotics as first line treatment for patients with painless otorrhea associated with tympanic membrane perforation or tympanostomy tube, and (5) Don't perform particle repositioning maneuvers without a clinical diagnosis of posterior canal benign paroxysmal positional vertigo."
9.	Vitamin D FDA LinkGeneric 07/01/2023 - "This study aimed to evaluate the association between serum vitamin D levels and benign paroxysmal positional vertigo (BPPV). " 12/01/2022 - "The aim of this study is to establish a relationship between vitamin D levels and benign paroxysmal positional vertigo (BPPV) and its recurrence; and to evaluate the remedial effect of vitamin D on BPPV. " 11/01/2021 - "Several studies have reported an association between benign paroxysmal positional vertigo (BPPV) and bone mineral density or serum vitamin D levels. " 01/01/2020 - "Prevention of benign paroxysmal positional vertigo with vitamin D supplementation: A randomized trial." 01/01/2020 - "Association between serum vitamin D levels and benign paroxysmal positional vertigo: a systematic review and meta-analysis of observational studies."
10.	hydroxide ionIBA 02/01/2010 - "The aim of this study was to investigate a possible correlation between post-benign paroxysmal positional vertigo (BPPV) dizziness and orthostatic hypotension (OH) using the head-up tilt test (HUTT). " 10/01/2023 - "Our study observed low vitamin D status in patients with benign paroxysmal positional vertigo, with no significant differences of the 25(OH)D level in patients with benign paroxysmal positional vertigo and controls. " 01/01/2019 - "Background: The present study aimed to evaluate serum 25-hydroxy vitamin D (25(OH) D) levels in Chinese patients with idiopathic benign paroxysmal positional vertigo (BPPV) and to investigate the possible relationship between the occurrence and recurrence of idiopathic BPPV and low 25(OH) D levels. " 10/01/2023 - "The results showed low vitamin D status both in benign paroxysmal positional vertigo and controls, with no significant difference of 25(OH)D levels between benign paroxysmal positional vertigo patients and controls (P > 0.05). " 01/01/2023 - "A low serum 25-hydroxyvitamin D (25(OH)D) level is relevant to both the occurrence and recurrence of benign paroxysmal positional vertigo (BPPV). "

Therapies and Procedures

1.	Therapeutics 08/01/2005 - "To demonstrate that a single therapy is effective for treating all subtypes of horizontal canal benign paroxysmal positional vertigo (HC-BPPV). " 02/01/2003 - "Particle repositioning manoeuvres are broadly recognized effective for benign paroxysmal positional vertigo (BPPV), however, we think that these therapies are not suitable for all BPPV patients. " 05/12/2023 - "Effectiveness of Epley-Canalith Repositioning Procedure versus Vestibular Rehabilitation Therapy in Diabetic Patients with Posterior Benign Paroxysmal Positional Vertigo: A Randomized Trial." 08/01/2021 - "And it may be significant for future studies of targeted prevention and therapies for benign paroxysmal positional vertigo." 07/01/2018 - "Objective:The objective of this article is to study the characteristics of benign paroxysmal positional vertigo (BPPV) and the influencing factors of residual symptoms after otolith repositioning therapy, so as to provide references for clinical diagnosis and treatment.Method"
2.	Lasers (Laser) 02/01/2021 - "Laser irradiation of the semicircular canal (SCC) is a good treatment for intractable benign paroxysmal positional vertigo. " 05/01/2010 - "Efficacy of laser occlusion of posterior semicircular canal for benign paroxysmal positional vertigo: case report." 05/01/1996 - "The purpose of this study was to compare the effectiveness of mechanical and laser-assisted posterior semicircular canal occlusion (PCO) for the treatment of intractable benign paroxysmal positional vertigo (BPPV). " 05/01/2010 - "To our knowledge, this is the first report in the world literature of a patient with refractory benign paroxysmal positional vertigo being treated with laser occlusion of the posterior semicircular canal. " 05/01/2010 - "We treated a patient with refractory benign paroxysmal positional vertigo using laser occlusion of the posterior semicircular canal, and achieved satisfactory results. "
3.	Osteopathic Manipulation 10/01/2017 - "The aim of the study was to evaluate the efficacy of osteopathic manipulative treatment (OMT) in patients with Benign-Paroxysmal-Positional Vertigo (BPPV). "
4.	Telerehabilitation 04/01/2023 - "Are Telerehabilitation Exercise Practices Effective in Patients Diagnosed with Benign Paroxysmal Positional Vertigo?" 04/01/2023 - "The aim of this study was to investigate the effectiveness of classical Vestibular Rehabilitation Exercises (Control Group-CG) given as home exercise program and VR + balance exercises (Experimental Group-EG) applied with telerehabilitation method on patients with Benign Paroxysmal Positional Vertigo (BPPV). "
5.	Stapes Surgery (Stapedectomy) 07/01/2001 - "To determine the incidence of benign paroxysmal positional vertigo (BPPV) following stapedectomy in a patient group and the efficacy of the Epley maneuver in this group. " 07/01/2001 - "Benign paroxysmal positional vertigo after stapedectomy." 03/01/1998 - "Canalith repositioning procedure for relief of post-stapedectomy benign paroxysmal positional vertigo."