The Relationship Between Disorders of Bone Metabolism and Benign Paroxysmal Positional Vertigo: A Systematic Review.

Abstract

OBJECTIVES:

Several studies have reported an association between benign paroxysmal positional vertigo (BPPV) and bone mineral density or serum vitamin D levels. The aim of this review is to provide further clarification regarding the relationship between BPPV and calcium metabolism.

DESIGN:

PubMed and MEDLINE databases were systematically reviewed to identify all English language papers regarding the relationship between BPPV and the following terms: osteoporosis, osteopenia, bone mineral density, serum vitamin D levels, and bone metabolism.

RESULTS:

Of the 456 identified records, 28 studies were eligible for this review. Most were retrospective studies with inherent limitations and often conflicting results. While the literature is not conclusive, osteoporosis in patients of at least 50 years old appears to have an association with BPPV. Similarly, an association was observed between recurrent BPPV and vitamin D deficiency.

CONCLUSION:

There is only weak evidence to support the relationship between BPPV and osteoporosis or low serum 25-hydroxyvitamin D levels. Further prospective studies with more robust methodologies are needed to clarify the association between BPPV and disorders of bone metabolism.

• Authors: Ambrose Lee, Fatemeh Hassannia, Michael J Bergin, Khalid Al Zaabi, Priyanka Misale, John Alexander Rutka
• Journal: Ear and hearing (Ear Hear) 2021 Nov-Dec 01 Vol. 42 Issue 6 Pg. 1462-1471 ISSN: 1538-4667 [Electronic] United States
• PMID: 34010250 (Publication Type: Journal Article, Systematic Review)
• Copyright: Copyright © 2021 Wolters Kluwer Health, Inc. All rights reserved.

Chemical References

• Vitamin D

Topics

• Benign Paroxysmal Positional Vertigo (complications)
• Humans
• Middle Aged
• Osteoporosis
• Prospective Studies
• Retrospective Studies
• Vitamin D