Estrogen Receptor Antagonists

Compounds and drugs that bind to and block or inhibit the activation of ESTROGEN RECEPTORS.

Also Known As:

Estradiol Receptor Antagonists; Antagonist, Estradiol Receptor; Antagonist, Estrogen Receptor; Antagonists, Estradiol Receptor; Antagonists, Estrogen Receptor; Receptor Antagonist, Estradiol; Receptor Antagonist, Estrogen; Receptor Antagonists, Estradiol; Receptor Antagonists, Estrogen; Estradiol Receptor Antagonist; Estrogen Receptor Antagonist

Networked: 153 relevant articles (10 outcomes, 19 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Zhang, Yazhuo: 4 articles (06/2014 - 04/2011)
2.	Krysan, Damian J: 3 articles (12/2018 - 08/2009)
3.	Gui, Songbai: 3 articles (06/2014 - 04/2011)
4.	Buzdar, Aman U: 3 articles (09/2008 - 01/2003)
5.	Liao, Yongde: 2 articles (02/2019 - 01/2014)
6.	Zhou, Sheng: 2 articles (02/2019 - 01/2014)
7.	Gangapuram, Madhavi: 2 articles (01/2017 - 04/2014)
8.	Redda, Kinfe K: 2 articles (01/2017 - 04/2014)
9.	Cao, Lei: 2 articles (06/2014 - 02/2014)
10.	Gao, Hua: 2 articles (06/2014 - 02/2014)

Related Diseases

1.	Breast Neoplasms (Breast Cancer) 12/25/2019 - "Estrogen receptor antagonists are effective in breast cancer treatment. " 09/01/1999 - "This trial highlighted the potential chemopreventive activity of selective estrogen-receptor antagonists as chemopreventives for breast cancer. " 11/08/2023 - "A novel scaffold long-acting selective estrogen receptor antagonist and degrader with superior preclinical profile against ER+ breast cancer." 01/01/2019 - "Leaves Against T47D Breast Cancer Cell Lines And Its Prediction As An Estrogen Receptor Antagonist Based On Pharmacophore-Molecular Dynamics Simulation." 01/01/2017 - "Tetrahydroisoqinoline derivatives (THIQs) were reported to act as selective subtype estrogen receptor antagonists/agonists and may serve as potential therapeutic agents for breast cancer. "
2.	Neoplasms (Cancer) 11/01/2002 - "In the protection of the female breast and endometrium from cancer progression it would be advantageous to inhibit estrogenic action, therefore many estrogen receptor antagonists have been made. " 01/01/2021 - "A pretreatment with the estrogen receptor antagonist tamoxifen blocked the tumor growth-promoting effects of each photoinitiator. " 01/01/2019 - "In these cancer patients, resistance to the anticancer estrogen receptor antagonist tamoxifen emerges to be a major clinical obstacle. " 05/01/2017 - "Expert opinion: Selective estrogen receptor down-regulators may exhibit clinical efficacy in the treatment of gynecological malignancies due to their pure estrogen receptor antagonist properties. " 06/15/2016 - "Although TAM was synthesized as an estrogen receptor antagonist, reports have found that a significant fraction of women with estrogen receptor-negative cancers have benefitted from TAM treatment, suggesting the possibility of an alternate anti-cancer mechanism. "
3.	Precocious Puberty 09/22/2012 - "The objective of this study was to evaluate the safety and efficacy of fulvestrant (FaslodexTM), a pure estrogen receptor antagonist, in girls with progressive precocious puberty (PP) associated with McCune-Albright Syndrome (MAS). "
4.	Prostatic Neoplasms (Prostate Cancer) 09/15/2008 - "In this trial we investigated the tolerability and efficacy of fulvestrant, a pure estrogen receptor antagonist, in the treatment of castration resistant prostate cancer (CRPC). "
5.	Polyostotic Fibrous Dysplasia (McCune Albright Syndrome) 09/22/2012 - "The objective of this study was to evaluate the safety and efficacy of fulvestrant (FaslodexTM), a pure estrogen receptor antagonist, in girls with progressive precocious puberty (PP) associated with McCune-Albright Syndrome (MAS). "

Related Drugs and Biologics

1.	Fulvestrant (Faslodex)
2.	Estradiol (Delestrogen)
3.	Estrogen Receptors
4.	Hormones (Hormone)
5.	Aromatase Inhibitors
6.	Genistein
7.	Steroids
8.	DNA (Deoxyribonucleic Acid)
9.	Temozolomide (Temodar)
10.	lipoarabinomannan (LAM)

Related Therapies and Procedures

1.	Therapeutics
2.	Castration
3.	Ovariectomy (Oophorectomy)
4.	Resuscitation
5.	Laparotomy