Bradykinin B1 Receptor Antagonists

Compounds and drugs that inhibit ligand binding or cellular signaling by BRADYKININ B1 RECEPTORS.

Also Known As:

Bradykinin B1 Antagonists; Bradykinin B1 Receptor Blockers; Bradykinin B1 Receptor Inhibitors; Antagonists, Bradykinin B1

Networked: 11 relevant articles (1 outcomes, 0 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Chemical Actions and Uses
- Pharmacologic Actions: 160
  - Molecular Mechanisms of Pharmacological Action: 24
    - Bradykinin Receptor Antagonists: 155
      - Bradykinin B1 Receptor Antagonists: 11

Experts

1.	Biswas, Kaustav: 3 articles (06/2011 - 01/2008)
2.	Chen, Jian Jeffrey: 3 articles (06/2011 - 01/2008)
3.	Bock, Mark G: 3 articles (01/2007 - 06/2003)
4.	Murphy, Kathy L: 3 articles (01/2007 - 06/2003)
5.	Pettibone, Douglas J: 3 articles (01/2007 - 06/2003)
6.	Ransom, Richard W: 3 articles (01/2007 - 06/2003)
7.	Askew, Benny C: 2 articles (06/2011 - 09/2008)
8.	Aya, Toshihiro: 2 articles (06/2011 - 09/2008)
9.	Human, Jason: 2 articles (06/2011 - 09/2008)
10.	Hungate, Randall W: 2 articles (06/2011 - 09/2008)

Related Diseases

1.	Pain (Aches) 08/12/2010 - "Bradykinin B1 receptor antagonists as potential therapeutic agents for pain." 01/01/2008 - "Small molecule bradykinin B1 receptor antagonists as potential therapeutic agents for pain." 01/25/2007 - "One of these novel bradykinin B1 antagonists (13b) also exhibited suitable pharmacokinetic properties and efficient ex vivo receptor occupancy for further development as a novel approach for the treatment of pain and inflammation." 06/25/2003 - "Selective bradykinin B1 receptor antagonists have been shown to be anti-nociceptive in animal models and could be novel therapeutic agents for the treatment of pain and inflammation. " 06/04/2012 - "Orally active peptidic bradykinin B1 receptor antagonists engineered from a cyclotide scaffold for inflammatory pain treatment."
2.	Bone Neoplasms (Bone Cancer) 11/01/2005 - "Analgesic efficacy of bradykinin B1 antagonists in a murine bone cancer pain model."
3.	Inflammation (Inflammations) 10/05/2016 - "The current findings suggest that selective bradykinin B1 receptor antagonists may have the therapeutic potential for the treatment of allergic airway inflammation. " 01/25/2007 - "One of these novel bradykinin B1 antagonists (13b) also exhibited suitable pharmacokinetic properties and efficient ex vivo receptor occupancy for further development as a novel approach for the treatment of pain and inflammation." 12/16/2004 - "Bradykinin B1 receptor antagonists embody a potentially novel approach for the treatment of chronic pain and inflammation. " 06/25/2003 - "Selective bradykinin B1 receptor antagonists have been shown to be anti-nociceptive in animal models and could be novel therapeutic agents for the treatment of pain and inflammation. " 06/01/2011 - "3-Oxo-2-piperazinyl acetamides as potent bradykinin B1 receptor antagonists for the treatment of pain and inflammation."
4.	Chronic Pain 12/16/2004 - "Bradykinin B1 receptor antagonists embody a potentially novel approach for the treatment of chronic pain and inflammation. " 09/01/2008 - "Aryl sulfones as novel bradykinin B1 receptor antagonists for treatment of chronic pain."
5.	Hyperalgesia 08/01/2003 - "Beneficial effect of chronic treatment with the selective bradykinin B1 receptor antagonists, R-715 and R-954, in attenuating streptozotocin-diabetic thermal hyperalgesia in mice."

Related Drugs and Biologics

1.	Analgesics (Analgesic Drugs)
2.	Cyclotides
3.	Sulfones
4.	Streptozocin (Streptozotocin)
5.	Acetamides
6.	R 715