Hypoxia-Inducible Factor-Proline Dioxygenases

Dioxygenase enzymes that specifically hydroxylate a PROLINE residue on the HYPOXIA-INDUCIBLE FACTOR 1, ALPHA SUBUNIT. They are OXYGEN-dependent enzymes that play an important role in mediating cellular adaptive responses to HYPOXIA.

Also Known As:

Egl Nine Homolog 1 Protein; Egl Nine Homolog 2 Protein; Egl Nine Homolog 3 Protein; HIF Prolyl-4-Hydroxylase; HIF Prolyl-4-Hydroxylases; Hypoxia-Inducible Factor Prolyl Hydroxylase 1; Hypoxia-Inducible Factor Prolyl Hydroxylase 2; Hypoxia-Inducible Factor Prolyl Hydroxylase 3; Hypoxia-Inducible Factor-Proline Dioxygenase; Dioxygenase, Hypoxia-Inducible Factor-Proline; Dioxygenases, Hypoxia-Inducible Factor-Proline; Factor-Proline Dioxygenase, Hypoxia-Inducible; Factor-Proline Dioxygenases, Hypoxia-Inducible; HIF Prolyl 4 Hydroxylase; HIF Prolyl 4 Hydroxylases; Hypoxia Inducible Factor Proline Dioxygenase; Hypoxia Inducible Factor Proline Dioxygenases; Hypoxia Inducible Factor Prolyl Hydroxylase 1; Hypoxia Inducible Factor Prolyl Hydroxylase 2; Hypoxia Inducible Factor Prolyl Hydroxylase 3; Prolyl-4-Hydroxylase, HIF; Prolyl-4-Hydroxylases, HIF

Networked: 27 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Experts

1.	Wenger, Roland H: 2 articles (09/2020 - 06/2013)
2.	DeMartino, Julie A: 2 articles (12/2016 - 04/2012)
3.	Hajdu, Richard: 2 articles (12/2016 - 04/2012)
4.	Hale, Jeffrey J: 2 articles (12/2016 - 04/2012)
5.	Lingham, Russell B: 2 articles (12/2016 - 04/2012)
6.	Milligan, James A: 2 articles (12/2016 - 04/2012)
7.	Salowe, Scott P: 2 articles (12/2016 - 04/2012)
8.	Sherer, Edward C: 2 articles (12/2016 - 04/2012)
9.	Sonatore, Lisa M: 2 articles (12/2016 - 04/2012)
10.	Tong, Xinchun: 2 articles (12/2016 - 04/2012)

Related Diseases

1.	Hypoxia (Hypoxemia) 04/01/2010 - "Here we demonstrate the potential clinical utility of low molecular weight inhibitors of the hypoxia inducible factor prolyl-4-hydroxylases (HIF PHDs) in preventing mitochondrial toxin-induced cell death in mouse striatal neurons that express a "knock-in" mutant Huntingtin allele. " 12/01/2008 - "[Clinical significance of hypoxia inducible factor-prolyl hydroxylase 1 and factor inhibiting hypoxia inducible factor-1 expression in placentas of women with severe pre-eclampsia]." 05/01/2010 - "Hypoxia-inducible factor prolyl-hydroxylase 2 senses high-salt intake to increase hypoxia inducible factor 1alpha levels in the renal medulla." 01/01/2007 - "Hypoxia inducible factor (HIF) prolyl-4-hydroxylase domain-containing proteins (PHDs) promote the degradation of HIF-1alpha. " 06/01/2013 - "Previously, we found strong Cdr2 protein expression in the papillary subtype of renal cell carcinoma (pRCC) and showed that Cdr2 interacts with the hypoxia-inducible factor (HIF) prolyl-4-hydroxylase PHD1. "
2.	Anemia 12/22/2016 - "Discovery of N-[Bis(4-methoxyphenyl)methyl]-4-hydroxy-2-(pyridazin-3-yl)pyrimidine-5-carboxamide (MK-8617), an Orally Active Pan-Inhibitor of Hypoxia-Inducible Factor Prolyl Hydroxylase 1-3 (HIF PHD1-3) for the Treatment of Anemia." 04/12/2012 - "1,3,8-Triazaspiro[4.5]decane-2,4-diones as efficacious pan-inhibitors of hypoxia-inducible factor prolyl hydroxylase 1-3 (HIF PHD1-3) for the treatment of anemia." 10/01/2022 - "Herein, we summarize the preclinical characteristics of the small molecule HIF prolyl-4-hydroxylase inhibitor vadadustat (AKB-6548), which is in development for the treatment of anemia in patients with chronic kidney disease (CKD). " 01/01/2023 - "Vadadustat is an investigational oral hypoxia-inducible factor (HIF) prolyl-4-hydroxylase inhibitor to treat anemia due to chronic kidney disease (CKD). " 09/01/2020 - "The three hypoxia-inducible factor (HIF) prolyl-4-hydroxylase domain (PHD) 1-3 enzymes confer oxygen sensitivity to the HIF pathway and are novel therapeutic targets for treatment of renal anemia. "
3.	Chronic Renal Insufficiency 10/01/2022 - "Herein, we summarize the preclinical characteristics of the small molecule HIF prolyl-4-hydroxylase inhibitor vadadustat (AKB-6548), which is in development for the treatment of anemia in patients with chronic kidney disease (CKD). " 01/01/2023 - "Vadadustat is an investigational oral hypoxia-inducible factor (HIF) prolyl-4-hydroxylase inhibitor to treat anemia due to chronic kidney disease (CKD). "
4.	Cardiomegaly (Heart Hypertrophy) 08/16/2022 - "Correction to: Loss of Endothelial Hypoxia Inducible Factor-Prolyl Hydroxylase 2 Induces Cardiac Hypertrophy and Fibrosis." 11/16/2021 - "Loss of Endothelial Hypoxia Inducible Factor-Prolyl Hydroxylase 2 Induces Cardiac Hypertrophy and Fibrosis."
5.	Fibrosis (Cirrhosis) 08/16/2022 - "Correction to: Loss of Endothelial Hypoxia Inducible Factor-Prolyl Hydroxylase 2 Induces Cardiac Hypertrophy and Fibrosis." 11/16/2021 - "Loss of Endothelial Hypoxia Inducible Factor-Prolyl Hydroxylase 2 Induces Cardiac Hypertrophy and Fibrosis."

Related Drugs and Biologics

1.	Enzymes
2.	Protein Isoforms (Isoforms)
3.	Transcription Factors (Transcription Factor)
4.	Proteins (Proteins, Gene)
5.	Oxygen (Dioxygen)
6.	Ketoglutaric Acids (Ketoglutaric Acid)
7.	vadadustat
8.	ErbB Receptors (EGF Receptor)
9.	Prolyl-Hydroxylase Inhibitors
10.	Dioxygenases