Death-Associated Protein Kinases

A family of calcium/calmodulin-dependent PROETIN-SERINE-THREONINE KINASES. They are ubiquitously expressed in adult and embryonic mammalian tissues, and their functions are tightly related to the early stages of eukaryotic programmed cell death.

Also Known As:

DAP Kinase; DAP Kinase 2; DAPK2; DAPL Kinase; DRP-1 Protein (Kinase); Death-Associated Protein Kinase 1; Death-Associated Protein Kinase 2; Death-Associated Protein Kinase 3; Death-Associated Protein Kinase-Related Protein 1; Death-Associated Protein-Like Kinase; SMPP-1M-Associated Kinase; ZIP Kinase; ZIP-Like Kinase; Death Associated Protein Kinase 1; Death Associated Protein Kinase 2; Death Associated Protein Kinase 3; Death Associated Protein Kinase Related Protein 1; Death Associated Protein Kinases; Death Associated Protein Like Kinase; Kinase 2, DAP; Kinase, DAP; Kinase, DAPL; Kinase, Death-Associated Protein-Like; Kinase, SMPP-1M-Associated; Kinase, ZIP; Kinase, ZIP-Like; Kinases, Death-Associated Protein; Protein Kinases, Death-Associated; Protein-Like Kinase, Death-Associated; SMPP 1M Associated Kinase; ZIP Like Kinase; Death Associated Protein Kinase

Networked: 439 relevant articles (2 outcomes, 56 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Chen, Ruey-Hwa: 11 articles (01/2020 - 02/2006)
2.	Tanaka, Tetsuji: 11 articles (07/2012 - 01/2004)
3.	Yukawa, Kazunori: 11 articles (07/2012 - 01/2004)
4.	Schneider-Stock, Regine: 10 articles (11/2019 - 06/2005)
5.	Bai, Tao: 10 articles (07/2012 - 01/2004)
6.	Lee, Tae Ho: 8 articles (06/2022 - 04/2011)
7.	Kimchi, Adi: 8 articles (01/2020 - 04/2004)
8.	Chen, Dongmei: 6 articles (06/2022 - 01/2019)
9.	Pei, Lei: 6 articles (10/2020 - 10/2014)
10.	Kimchi, A: 6 articles (05/2012 - 01/2001)

Related Diseases

1.	Neoplasms (Cancer) 01/01/2021 - "Disrupting this negative autoregulation by BET inhibitors (BETi) resulted in a striking increase in BCL6 transcription, which further activated the mTOR signaling pathway through repression of the tumor suppressor death-associated protein kinase 2. Importantly, pharmacological inhibition of either BCL6 or mTOR improved the tumor response and enhanced the sensitivity of KRAS-mutant NSCLC to BETi in both in vitro and in vivo settings. " 05/01/2004 - "Overall (64 months) and disease-free (63 months) survival in the high DAP-kinase expression group were significantly longer compared with the women whose tumors showed a loss of DAP-kinase expression (51 and 43 months, respectively). " 05/03/2016 - "This study suggests that miR-520g contributes to tumor progression and drug resistance by post-transcriptionally downregulating DAPK2, and that miR-520g may be a valuable therapeutic target in patients with EOC. " 07/24/1997 - "In this study the expression of DAP-kinase was examined in the cell lines derived from various human neoplasms. " 01/01/2023 - "In the intestinal epithelium, DAPK2 is associated with programmed cell death, potential tumor-suppressive functions, and a unique influence on granulocyte biology. "
2.	Non-Small-Cell Lung Carcinoma (Carcinoma, Non-Small Cell Lung) 01/01/2018 - "The objective was to study the correlation between death-associated protein kinase (DAPK) promoter methylation and the clinicopathological and prognostic features in nonsmall cell lung cancer (NSCLC) patients. " 01/01/2018 - "The aim was to investigate the significance of death-associated protein kinase (DAPK) methylation in non-small-cell lung cancer (NSCLC) through a meta-analysis. " 01/01/2018 - "Death-associated protein kinase promoter methylation correlates with clinicopathological and prognostic features in nonsmall cell lung cancer patients: A cohort study." 01/01/2015 - "This meta-analysis investigated the correlation between the promoter methylation of death-associated protein kinase (DAPK) and the clinicopathological features in patients with non-small cell lung cancer (NSCLC). " 06/01/2014 - "We performed a meta-analysis of cohort studies to determine whether promoter methylation of the death-associated protein kinase (DAPK) gene contributes to the pathogenesis of nonsmall cell lung cancer (NSCLC). "
3.	Lung Neoplasms (Lung Cancer) 01/01/2009 - "Therefore, we investigated the association between the aberrant promoter methylation of 2 genes: the Death-Associated Protein Kinase (DAPK) and the Ras Association Domain Family 1A (RASSF1A) by using methylation-specific PCR, and the clinicopathological features and prognosis in 70 radically resected non-small cell lung cancers (NSCLCs). " 08/01/2003 - "Epigenetic down-regulation of death-associated protein kinase in lung cancers." 07/01/2003 - "Expression silencing through CpG island methylation of DAP-kinase has been frequently found in connection with adverse survival, as cells lacking DAP-kinase appear to be more invasive and more metastatic in lung cancer. " 09/20/2000 - "Moreover, the groups with and without hypermethylation of the DAP kinase promoter showed a striking difference in the probability of disease-specific survival; i.e., among people who died of lung cancer-related causes specifically, the probability of 5-year survival was.56 for those with such hypermethylation and.92 for those without it (P:<.001). " 07/01/2003 - "It appears to play a role in lung cancer metastasis in animal models, suggesting that DAP-kinase may function as a metastasis suppressor by inducing apoptosis. "
4.	Urinary Bladder Neoplasms (Bladder Cancer) 03/01/2010 - "Methylation of DAP-kinase can be considered as one of the prognosis indicators for progression and development of bladder cancer." 03/01/2010 - "The increased risk of bladder cancer was 6.70-fold (95% confidence interval (CI) 2.09-23.87; p = 0.000) in those carrying methylated DAP-kinase and it was elevated in patients who smoked (odds ratio 7.87; 95% CI 1.50-54.96; p = 0.007). " 03/01/2010 - "Hypermethylation-mediated partial transcriptional silencing of DAP-kinase gene in bladder cancer." 07/15/2002 - "Our results suggest that hypermethylation of DAP-kinase might be a useful prognostic marker for disease recurrence in superficial bladder cancers." 07/15/2002 - "The association of death-associated protein kinase hypermethylation with early recurrence in superficial bladder cancers."
5.	Neoplasm Metastasis (Metastasis) 11/26/2019 - "The Death-associated protein kinase 1 (DAPK1), recently, has been shown to be a potential candidate for regulating metastasis in CRC. " 02/01/2014 - "Death-associated protein kinase (DAPK) plays an important role in apoptosis regulation and has been shown to maintain antitumor and metastasis suppressor properties. " 02/01/2014 - "Recent evidence has emerged that death-associated protein kinase (DAPK) is a candidate of metastasis suppressor. " 07/15/2012 - "We showed that miR-103/107 targeted the known metastasis suppressors death-associated protein kinase (DAPK) and Krüppel-like factor 4 (KLF4) in CRC cells, resulting in increased cell motility and cell-matrix adhesion and decreased cell-cell adhesion and epithelial marker expression. " 11/30/2001 - "Alterations of signal transduction pathways leading to Dlk/ZIP kinase induced apoptosis or loss of expression of upstream activators could play important roles in tumour progression and metastasis of neural tumours."

Related Drugs and Biologics

1.	Proteins (Proteins, Gene)
2.	Cadherins (E-Cadherin)
3.	Death-Associated Protein Kinases
4.	Phosphotransferases (Kinase)
5.	DNA (Deoxyribonucleic Acid)
6.	retinoic acid receptor beta
7.	Messenger RNA (mRNA)
8.	O(6)-Methylguanine-DNA Methyltransferase
9.	Decitabine
10.	Cyclin-Dependent Kinase Inhibitor p16

Related Therapies and Procedures

1.	Drug Therapy (Chemotherapy)
2.	Cardiopulmonary Resuscitation (CPR)
3.	Therapeutics
4.	Chemoradiotherapy
5.	Bariatric Surgery