Myeloid Cell Leukemia Sequence 1 Protein

A member of the myeloid leukemia factor (MLF) protein family with multiple alternatively spliced transcript variants encoding different protein isoforms. In hematopoietic cells, it is located mainly in the nucleus, and in non-hematopoietic cells, primarily in the cytoplasm with a punctate nuclear localization. MLF1 plays a role in cell cycle differentiation.

Also Known As:

Networked: 56 relevant articles (1 outcomes, 4 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Wan, Yichao: 3 articles (11/2020 - 12/2015)
2.	Fang, Hao: 3 articles (10/2017 - 12/2015)
3.	Roberts, Andrew W: 2 articles (11/2020 - 11/2017)
4.	Liu, Tingting: 2 articles (10/2017 - 01/2017)
5.	Song, Ting: 2 articles (10/2013 - 02/2011)
6.	Zhang, Zhichao: 2 articles (10/2013 - 02/2011)
7.	Liao, Xuemei: 2 articles (11/2011 - 02/2010)
8.	Xu, Jianzhen: 2 articles (11/2011 - 02/2010)
9.	Chen, Qin: 1 article (01/2022)
10.	Jiang, Nan: 1 article (01/2022)

Related Diseases

1.	Melanoma (Melanoma, Malignant) 11/01/2011 - "Herein, we demonstrate that miR-193b also down-regulates myeloid cell leukemia sequence 1 (Mcl-1) in melanoma cells. " 08/05/2020 - "We explored the efficacy of combining two BH3 mimetics, ABT-199 and a myeloid cell leukemia sequence 1 (MCL1) inhibitor (S63845 or S64315/MIK665) in cutaneous, mucosal and acral melanomas, in vitro and in vivo. "
2.	B-Cell Lymphoma (Lymphoma, B Cell) 11/26/2015 - "Simultaneous targeting of B-cell lymphoma-extra large and myeloid cell leukemia sequence 1 led to apoptosis in several cell types. " 10/01/2013 - "Notably, an enthalpy gain of 4.65 kcal/mol identified that an additional hydrogen bond is formed by 2 with myeloid cell leukemia sequence 1 compared with compound 1. For the first time, hydrogen bonding between a small-molecule inhibitor of B-cell lymphoma 2 was demonstrated experimentally." 02/15/2010 - "Bioinformatics analysis revealed that anti-apoptosis family member B-cell lymphoma 2 (Bcl-2) and myeloid cell leukemia sequence 1 (Mcl-1) are potential targets of miR-153. " 10/01/2004 - "In transgenic mice over expressing the anti-apoptotic Bcl-2 family member, myeloid cell factor-1 (Mcl-1), B cell lymphomas occur. " 01/01/2014 - "The purpose of this study is to analyze the expression pattern of miR-29a/29b and its target genes Mcl-1 (myeloid cell leukemia sequence 1) and B-cell lymphoma 2 (Bcl-2) in myeloid leukemia. "
3.	Neoplasms (Cancer) 10/01/2020 - "A pro‑survival member of the Bcl‑2 family, myeloid cell leukemia sequence 1 (Mcl‑1) is also frequently overexpressed in multiple cancers and is associated with poorer clinical outcomes for patients. " 05/01/2013 - "Of the different members in the BCL-2 family, myeloid cell leukemia sequence 1 (MCL-1) is commonly amplified in human tumors and is associated with their relapse and chemoresistance. " 10/01/2012 - "Myeloid cell leukemia sequence 1 (Mcl-1), an antiapoptotic member of the Bcl-2 family, is often overexpressed in tumor cells limiting the therapeutic success. " 03/11/2005 - "Increased levels of Mcl-1 (myeloid cell factor-1) have been reported in several cancers, suggesting an important role played by Mcl-1 in cancer cell survival. " 01/01/2021 - "In fluorochrome guided, competitive in vivo trials, silencing of the apoptosis regulator MCL1 (myeloid cell leukemia sequence 1) correlates to pharmacological MCL1 inhibition in patients´ tumors, demonstrating the ability of the method to detect therapeutic vulnerabilities. "
4.	Ovarian Neoplasms (Ovarian Cancer) 06/01/2014 - "The percentage of positive myeloid cell leukemia sequence 1, ATG9A, and MAPK10 protein expression and low miR-29b mRNA expression were significantly higher in cases with clinical stage III and IV ovarian cancer than in cases with clinical stage II ovarian cancer. " 05/01/2014 - "EDD knockdown by small interfering RNA (siRNA) induced apoptosis in A2780ip2, OVCAR5 and ES-2 ovarian cancer cells, correlating with loss of the prosurvival protein myeloid cell leukemia sequence 1 (Mcl-1) through a glycogen synthase kinase 3 beta-independent mechanism. " 06/01/2014 - "In this study, the expression of miR-29b messenger RNA (mRNA) and its targeted genes, myeloid cell leukemia sequence 1, mitogen-activated protein kinase 10 (MAPK10), and autophagy-related protein 9A (ATG9A), were investigated in ovarian carcinomas, and their associations with clinicopathological characteristics and survival of patients with ovarian cancer were analyzed. "
5.	Myeloid Leukemia (Leukemia, Myelocytic) 01/01/2014 - "The purpose of this study is to analyze the expression pattern of miR-29a/29b and its target genes Mcl-1 (myeloid cell leukemia sequence 1) and B-cell lymphoma 2 (Bcl-2) in myeloid leukemia. " 01/01/2014 - "Myeloid cell leukemia sequence 1 (Mcl-1) is an anti-apoptotic Bcl-2 family protein and an immediate early gene expressed during myeloid leukemia cell line differentiation. "

Related Drugs and Biologics

1.	venetoclax
2.	S63845
3.	Mitogen-Activated Protein Kinase 10
4.	Messenger RNA (mRNA)
5.	Pyrroles
6.	Fluorescent Dyes (Fluorescent Probes)
7.	Autophagy-Related Proteins
8.	mouse MIRN29 microRNA
9.	Proteins (Proteins, Gene)
10.	Apoptosis Regulatory Proteins

Related Therapies and Procedures

1.	Therapeutics