Geminin

Geminin inhibits DNA replication by preventing the incorporation of MCM complex into pre-replication complex. It is absent during G1 phase of the CELL CYCLE and accumulates through S, G2,and M phases. It is degraded at the metaphase-anaphase transition by the ANAPHASE-PROMOTING COMPLEX-CYCLOSOME.

Networked: 138 relevant articles (2 outcomes, 17 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Taraviras, Stavros: 10 articles (01/2022 - 08/2004)
2.	Lygerou, Zoi: 9 articles (01/2022 - 08/2004)
3.	Stoeber, Kai: 8 articles (01/2018 - 10/2004)
4.	Ochiai, Atsushi: 7 articles (02/2019 - 06/2010)
5.	Dutta, Anindya: 7 articles (10/2007 - 07/2002)
6.	Ito, Hisao: 6 articles (09/2012 - 05/2009)
7.	Shomori, Kohei: 6 articles (09/2012 - 05/2009)
8.	Williams, Gareth H: 6 articles (12/2009 - 10/2004)
9.	DePamphilis, Melvin L: 5 articles (10/2019 - 06/2011)
10.	Ishii, Genichiro: 5 articles (02/2019 - 04/2011)

Related Diseases

1.	Neoplasms (Cancer) 10/01/2018 - "Several studies have shown that geminin depletion in vitro results in rereplication and DNA damage, whereas increased expression of geminin has been observed in human cancers. " 08/01/2010 - "Recent studies have suggested that geminin expression is a marker of the S/G2/M phase of the cell cycle and is associated with a poor prognosis in various human malignancies. " 04/01/2010 - "Recent studies have proposed that MCM7 and geminin may be sensitive proliferative and prognostic markers of various malignant tumors. " 01/01/2005 - "In this study, we evaluated by Western blot analysis the expression of geminin in a series of human cancer cell lines of various histogenetic origin and in a series of human primary colon, rectal, and breast cancers. " 07/01/2022 - "Forty cases of each tumor were immuostained with ki67, MCM2, and geminin followed by assessment of labeling indices (LIs). "
2.	Breast Neoplasms (Breast Cancer) 01/01/2014 - "We aimed to compare the prognostic significance of geminin to that of Ki67, a proliferation marker which has been investigated in many breast cancer studies. " 10/01/2004 - "The present study has investigated whether the frequency of geminin expression predicts clinical outcome in breast cancer. " 06/01/2017 - "Moreover, elevated levels of geminin, HDAC3, or both together with decreased FoxO3 acetylation and reduced Dicer expression were detected in aggressive human breast cancer specimens. " 06/01/2017 - "Breast cancer cells depleted of geminin or HDAC3 exhibited poor metastatic potential that was attributed to reduced suppression of the FoxO3-Dicer axis. " 01/01/2017 - "Altogether, our data identify DUB3 and USP7 as factors that regulate DNA replication by controlling Geminin protein stability, and suggest that USP7 may be involved in Geminin dysregulation during breast cancer progression."
3.	Genomic Instability 10/01/2019 - "The Cdk2-c-Myc-miR-571 Axis Regulates DNA Replication and Genomic Stability by Targeting Geminin." 08/15/2010 - "Geminin is a cell cycle regulator which controls licensing of origins for DNA replication, safeguarding genomic stability. " 07/29/2008 - "Our findings suggest that PcG complex 1 supports the activity of hematopoietic stem cells, in which high-level Geminin expression induces quiescence securing genome stability, by enhancing cycling capability and hematopoietic activity through direct regulation of Geminin." 01/06/2005 - "This review proposes that a balance between Cdt1 and geminin is important for maintaining genomic stability." 05/24/2004 - "These data show that Geminin is required for maintaining genomic stability in human cells."
4.	Squamous Cell Carcinoma of Head and Neck 04/01/2010 - "This study aimed to analyze the expression of MCM7 and geminin to clarify pathobiological significance in human oral squamous cell carcinomas (OSCCs). " 04/01/2010 - "Minichromosome maintenance-7 and geminin are reliable prognostic markers in patients with oral squamous cell carcinoma: immunohistochemical study." 11/01/2019 - "In oral squamous cell carcinoma, lower geminin expression was observed in recurrent cases. " 11/01/2019 - "Geminin reactivity was widely distributed in high-grade dysplasia and oral squamous cell carcinoma rather than low-grade or no dysplastic cases. " 04/07/2009 - "Mcm2 and geminin have been scarcely explored in oral epithelial dysplasia (OED) and oral squamous-cell carcinoma (OSCC). "
5.	Aneuploidy (Aneuploid) 05/19/2011 - "Geminin overexpression prevents the completion of topoisomerase IIα chromosome decatenation, leading to aneuploidy in human mammary epithelial cells." 12/01/2011 - "The current study reveals that geminin is a genuine oncogene that promotes cytokinesis failure and production of aneuploid, aggressive breast tumors when overexpressed and thus a worthy therapeutic target (oncotarget) for aggressive breast cancer." 12/01/2011 - "Geminin overexpressing human mammary epithelial cells form aneuploid, aggressive tumors in SCID mice. " 12/01/2009 - "Increased Ki67, Mcm2, and geminin levels were each significantly associated with arrested tumor differentiation (P < 0.0001) and aneuploidy (P < or = 0.01). " 05/01/2008 - "Aberrant expression of Cdt1 and Geminin is thus linked to DNA replication defects, aneuploidy and genomic instability. "

Related Drugs and Biologics

1.	Imatinib Mesylate (Gleevec)
2.	Proteins (Proteins, Gene)
3.	Cyclin A
4.	Messenger RNA (mRNA)
5.	Apigenin
6.	Flavonoids
7.	Type II DNA Topoisomerases (Topoisomerase II)
8.	SYBR Green I
9.	trioctyl phosphine oxide (TOPO)
10.	DNA (Deoxyribonucleic Acid)

Related Therapies and Procedures

1.	Drug Therapy (Chemotherapy)
2.	Therapeutics
3.	Induction Chemotherapy
4.	Mammaplasty (Breast Reconstruction)
5.	Transplantation