Sulfonylurea Receptors

ATP-BINDING CASSETTE PROTEINS that are highly conserved and widely expressed in nature. They form an integral part of the ATP-sensitive potassium channel complex which has two intracellular nucleotide folds that bind to sulfonylureas and their analogs.

Also Known As:

Networked: 191 relevant articles (4 outcomes, 18 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Simard, J Marc: 26 articles (12/2020 - 04/2006)
2.	Gerzanich, Volodymyr: 21 articles (12/2020 - 04/2006)
3.	Ivanova, Svetlana: 14 articles (12/2020 - 04/2006)
4.	Shyng, Show-Ling: 10 articles (01/2019 - 05/2002)
5.	Stanley, Charles A: 8 articles (10/2016 - 09/2003)
6.	Tsymbalyuk, Orest: 6 articles (01/2019 - 08/2007)
7.	Woo, Seung Kyoon: 6 articles (01/2019 - 03/2012)
8.	Tosun, Cigdem: 6 articles (08/2015 - 02/2009)
9.	Kimberly, W Taylor: 5 articles (01/2020 - 09/2012)
10.	Sheth, Kevin N: 5 articles (01/2020 - 09/2012)

Related Diseases

1.	Ischemia 01/01/2018 - "A subunit of the sulfonylurea receptor 1-transient receptor potential M4 (Sur1-TRPM4) channel has been implicated in the pathogenesis of ischemia-evoked cerebral edema. " 02/01/2009 - "Here, we studied a rat model of mild-to-moderate SAH intended to minimize ischemia/hypoxia to examine the role of sulfonylurea receptor 1 (SUR1) in the inflammatory response induced by SAH. " 01/01/2020 - "Glibenclamide protects against ischemic injury in both preclinical and clinical studies, presumably by blocking the de novo assembled sulfonylurea receptor 1-transient receptor potential M4 (Sur1-Trpm4) channel induced by ischemia. " 05/01/2004 - "Differences in their binding affinity to the beta-cell sulfonylurea receptor have been described, with preservation of cardioprotective responses to ischemia with glimepiride. " 01/01/2014 - "Preclinical and retrospective clinical data indicate that glyburide, a selective inhibitor of sulfonylurea receptor 1-transient receptor potential melastatin 4, is effective in preventing edema and improving outcome after focal ischemia. "
2.	Hemorrhage 01/01/2019 - "Thus, our results suggest that PCA improved functional recovery after SCI in part by inhibiting BSCB disruption and hemorrhage through the down-regulation of sulfonylurea receptor 1/transient receptor potential melastatin 4 and matrix metalloprotease-9." 01/01/2019 - "SCI can lead to hemorrhage by engaging the sulfonylurea receptor 1 (SUR1) transient receptor potential melastatin 4 (TRPM4) channel complex in neurovascular endothelial cells, which leads to cell death and capillary fragmentation. " 01/01/2018 - "In addition, the expression of sulfonylurea receptor 1 (SUR1) and transient receptor potential melastatin 4 (TRPM4), which are known to mediate hemorrhage at an early stage after SCI, was significantly blocked by MA treatment. " 10/01/2023 - "Over the past decade, there has been increasing evidence of the role of the sulfonylurea-receptor 1-transient receptor potential melastatin 4 (SUR1-TRPM4) channel in secondary injury after TBI, including progression of both cerebral edema and intraparenchymal hemorrhage. " 12/01/2009 - "Key role of sulfonylurea receptor 1 in progressive secondary hemorrhage after brain contusion."
3.	Middle Cerebral Artery Infarction (Middle Cerebral Artery Syndrome) 04/29/2014 - "The aim of this study was to explore the expression of sulfonylurea receptor 1 (SUR1), the regulatory subunit of the NCCa-ATP channel, and to investigate the protective effects of gliclazide following middle cerebral artery occlusion (MCAO)/reperfusion in male Wistar rats. " 08/01/2015 - "In a rat model of middle cerebral artery occlusion stroke, pharmacologic channel blockade by glibenclamide, a selective inhibitor of sulfonylurea receptor, mitigated perivascular tumor necrosis factor labeling. "
4.	Edema (Dropsy) 08/01/2015 - "It associates with sulfonylurea receptor 1 (Sur1) to form Sur1-Trpm4 channels, which have critical roles in cytotoxic edema, cell death, blood-brain barrier breakdown, and vasogenic edema. " 01/01/2021 - "The CARMIL3(+) neurons and neurites in the mismatch and T2(+) areas were larger than those in the control area, and associated with (1) increased expression of sulfonylurea receptor 1 (SUR1), indicating edema, (2) accumulation of p62, indicating impaired autophagy, and (3) increase in 8-hydroxy-2'-deoxyguanosine (8-OHdG), indicating oxidative stress. " 01/01/2016 - "Recently, it has become possible to reduce edema after CNS injury by antagonizing a sulfonylurea receptor 1 (SUR1) regulated ion channel expressed after injury. " 01/01/2014 - "Preclinical and retrospective clinical data indicate that glyburide, a selective inhibitor of sulfonylurea receptor 1-transient receptor potential melastatin 4, is effective in preventing edema and improving outcome after focal ischemia. " 01/01/2021 - "Vasogenic edema in the setting of acute ischemic stroke can be attributed to the opening of transient receptor potential 4 channels, which are expressed in the setting of injury and regulated by sulfonylurea receptor 1 (SUR1) proteins. "
5.	Hyperglycemia 01/01/2015 - "Mitiglinide, a short-acting insulinotropic sulfonylurea receptor ligand, is effective for postprandial hyperglycemia. " 06/01/2014 - "Mitiglinide is a rapid- and short-acting insulinotropic sulfonylurea receptor ligand that is known to improve postprandial hyperglycemia in patients with type 2 diabetes. "

Related Drugs and Biologics

1.	Adenosine Triphosphate (ATP)
2.	Glyburide (Glibenclamide)
3.	Ligands
4.	Gliclazide (Diamicron)
5.	mitiglinide
6.	Glucokinase
7.	KATP Channels
8.	Insulin (Novolin)
9.	Cations
10.	Proteins (Proteins, Gene)

Related Therapies and Procedures

1.	Cardiopulmonary Resuscitation (CPR)