Anaphase-Promoting Complex-Cyclosome Apc11 Subunit

Together with the Apc2 subunit, forms the catalytic core of the E3 ubiquitin ligase, anaphase-promoting complex-cyclosome. It has a RING H2 domain which interacts with the cullin domain of Apc2. Apc11 also interacts with the E2 ubiquitin ligases involved in APC-C ubiquitination reactions.

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Networked: 3 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Experts

1.	Zhang, Yu: 1 article (07/2020)
2.	Zhou, Hongyan: 1 article (07/2020)
3.	Chan, A H: 1 article (08/2001)
4.	Chim, S S: 1 article (08/2001)
5.	Fung, K P: 1 article (08/2001)
6.	Kok, L D: 1 article (08/2001)
7.	Lee, C Y: 1 article (08/2001)
8.	Lee, S M: 1 article (08/2001)
9.	Tsui, S K: 1 article (08/2001)
10.	Waye, M M: 1 article (08/2001)

Related Diseases

1.	Liver Neoplasms (Liver Cancer) 08/01/2001 - "The human homolog of Apc11p, ANAPC11 was identified during a large-scale partial sequencing of a human liver cancer cDNA library and partial characterization was performed. " 07/01/2020 - "Collectively, the results of the present study demonstrated that lncRNA BCAR4 may promote liver cancer development by directly binding to miR‑1261 and targeting ANAPC11." 07/01/2020 - "Consistently, overexpression of ANAPC11 or inhibition of miR‑1261 significantly rescued liver cancer cell proliferation induced by knockdown of lncRNA BCAR4. " 07/01/2020 - "LncRNA BCAR4 promotes liver cancer progression by upregulating ANAPC11 expression through sponging miR‑1261."
2.	Neoplasms (Cancer) 08/01/2001 - "Expression level of ANAPC11 is found higher in certain types of cancer determined in the RNA dot blot experiment."
3.	Neoplasm Metastasis (Metastasis) 12/01/2023 - "By employing a series of in vitro experiments, we demonstrated that ANAPC11 enhanced the proliferation and invasiveness of UBC cells, while knockout of ANAPC11 inhibited the growth and LN metastasis of UBC cells in vivo. " 12/01/2023 - "Our clinical analysis showed that elevated expression of ANAPC11 was significantly correlated with high T stage, positive lymph node (LN) metastasis, and poor outcomes in UBC patients. "
4.	Lymphatic Metastasis 12/01/2023 - "The APC/C E3 ligase subunit ANAPC11 mediates FOXO3 protein degradation to promote cell proliferation and lymph node metastasis in urothelial bladder cancer."
5.	Urinary Bladder Neoplasms (Bladder Cancer) 12/01/2023 - "The APC/C E3 ligase subunit ANAPC11 mediates FOXO3 protein degradation to promote cell proliferation and lymph node metastasis in urothelial bladder cancer."

Related Drugs and Biologics

1.	Long Noncoding RNA
2.	Ubiquitin-Protein Ligases (Ubiquitin-Protein Ligase)
3.	RNA (Ribonucleic Acid)
4.	Forkhead Box Protein O3