Vascularized Composite Allotransplantation

Transference of multiple tissues, such as muscle, bone, nerve, and skin, as a functional unit for reconstructive purposes. Blood supply to the transplanted tissues is maintained throughout the transplantation procedure with minimal ischemia. Maintenance of vascularity in the graft promotes its viability, function, and survival in the recipient.

Also Known As:

Networked: 75 relevant articles (4 outcomes, 4 trials/studies)

Relationship Network

Therapy Context: Research Results

Experts

1.	Pomahac, Bohdan: 5 articles (10/2022 - 01/2013)
2.	Brandacher, Gerald: 5 articles (01/2020 - 10/2013)
3.	Lee, W P Andrew: 4 articles (01/2020 - 10/2013)
4.	Schneeberger, Stefan: 4 articles (01/2020 - 10/2013)
5.	Cetrulo, Curtis L: 4 articles (11/2017 - 11/2011)
6.	Hautz, Theresa: 3 articles (01/2020 - 12/2013)
7.	Siemionow, Maria: 3 articles (06/2016 - 11/2007)
8.	Avery, Robin K: 3 articles (04/2014 - 04/2011)
9.	Gordon, Chad R: 3 articles (04/2014 - 04/2011)
10.	Gebhard, Martha Maria: 3 articles (01/2011 - 04/2004)

Related Diseases

1.	Wounds and Injuries (Trauma) 12/01/2019 - "Vascularized composite allotransplantation (VCA), a life-enhancing treatment for patients with complex tissue defects, trauma or illness, expounds upon the foundation of solid organ transplantation (SOT), the gold standard in end-stage organ failure. " 11/01/2012 - "This model will facilitate study of autotransplant physiology as well as vascularized composite allotransplantation as an evolving method for reconstructing previously nonreconstructable injuries. " 10/23/2023 - "In the past decade, vascularized composite allotransplantation (VCA) has become clinical reality for reconstruction after face and hand trauma. " 03/29/2023 - "Vascularized composite allotransplantation addresses injuries to complex anatomical structures such as the face, hand, and abdominal wall. " 01/01/2023 - "Vascularized composite allotransplantation (VCA) is a restorative surgical procedure to treat whole or partially disfiguring craniofacial or limb injuries. "
2.	Burns 11/01/2012 - "Full-face, whole, full-thickness skin grafting appears to be an effective and relatively simple method for full-face burns that do not respond well to facial composite tissue allotransplantation (CTA)." 01/01/2021 - "Vascularized composite allotransplantation performed for burn reconstruction was found to be associated with a greater risk of 1-year mortality and nearly twice the number of episodes of acute rejection. " 01/01/2021 - "Articles containing vascularized composite allotransplantation, composite tissue allotransplantation, and burn reconstructive surgery were included; articles without published outcomes were excluded. " 01/01/2021 - "To investigate this, a systematic review of vascularized composite allotransplantation employed for burn reconstruction was conducted, evaluating literature from January 2000 to September 2019. " 01/01/2021 - "Vascularized composite allotransplantation has been successfully employed for burn reconstruction since 2003. "
3.	Atherosclerosis 06/01/2020 - "Theses reviewed in this issue include "Clearance of Capillary Occlusions Improves Cortical Blood Flow and Cognitive Function in Alzheimer's Mouse Models," "Dermato-Informatic Approaches to Understanding and Improving Lesional Diagnostic Expertise in Cutaneous Oncology," "Furthering the Scope, Understanding, and Application of Proteolysis Targeting Chimera," "Optimization and Application of Synthetic High-Density Lipoprotein (sHDL) System in Atherosclerosis and Glioma Therapy," "Regulatory T Cell Enriching Microparticles for Promoting Tolerance in Vascularized Composite Allotransplantation," and "Tau Prion Strains Induce Distinct Pathological Phenotypes In Vivo.""
4.	Glioma (Gliomas) 06/01/2020 - "Theses reviewed in this issue include "Clearance of Capillary Occlusions Improves Cortical Blood Flow and Cognitive Function in Alzheimer's Mouse Models," "Dermato-Informatic Approaches to Understanding and Improving Lesional Diagnostic Expertise in Cutaneous Oncology," "Furthering the Scope, Understanding, and Application of Proteolysis Targeting Chimera," "Optimization and Application of Synthetic High-Density Lipoprotein (sHDL) System in Atherosclerosis and Glioma Therapy," "Regulatory T Cell Enriching Microparticles for Promoting Tolerance in Vascularized Composite Allotransplantation," and "Tau Prion Strains Induce Distinct Pathological Phenotypes In Vivo.""
5.	Arthritis (Polyarthritis) 08/01/2017 - "Elbow reconstruction with vascularized composite allotransplantation (VCA) may hold promise in treating end-stage arthritis as no current treatment is both functional and durable. "

Related Drugs and Biologics

1.	Prions
2.	HDL Lipoproteins
3.	Proteolysis Targeting Chimera
4.	lead oxide
5.	Solutions
6.	Tacrolimus (Prograf)
7.	Plastics
8.	Dermal Fillers

Related Therapies and Procedures

1.	Organ Transplantation
2.	Skin Transplantation (Skin Grafting)
3.	Therapeutics
4.	Facial Transplantation
5.	Hand Transplantation