2',3'-Cyclic Nucleotide 3'-Phosphodiesterase

A phosphodiesterase that specifically cleaves the 3'-phosphate linkage of 2',3'-cyclic nucleotides. It is found at high level in the cytoplasm of cells that form the MYELIN SHEATH.

Also Known As:

2',3'-CN Phosphodiesterase; 2',3'-CNPase; Cyclic CMP Phosphodiesterase; 2',3' CN Phosphodiesterase; 2',3' CNPase; 2',3' Cyclic Nucleotide 3' Phosphodiesterase; 2',3' Cyclic Nucleotide 3' Phosphodiesterases; 3'-Phosphodiesterase, 2',3'-Cyclic Nucleotide; 2',3'-Cyclic Nucleotide 3'-Phosphodiesterases

Networked: 41 relevant articles (0 outcomes, 6 trials/studies)

Bio-Agent Context: Research Results

Experts

1.	Barradas, P C: 2 articles (04/2007 - 12/2000)
2.	Ferreira, A A: 2 articles (04/2007 - 12/2000)
3.	Haroutunian, Vahram: 2 articles (02/2007 - 01/2006)
4.	Bennet, L: 1 article (12/2019)
5.	Davidson, J O: 1 article (12/2019)
6.	Draghi, V: 1 article (12/2019)
7.	Gunn, A J: 1 article (12/2019)
8.	Wassink, G: 1 article (12/2019)
9.	Zhou, K Q: 1 article (12/2019)
10.	Bansal, Rashmi: 1 article (01/2016)

Related Diseases

1.	Schizophrenia (Dementia Praecox) 04/06/2009 - "No relationship between 2',3'-cyclic nucleotide 3'-phosphodiesterase and schizophrenia in the Chinese Han population: an expression study and meta-analysis." 04/12/2007 - "Case-control association study of the 2',3'-cyclic nucleotide 3'-phosphodiesterase (CNP) gene and schizophrenia in the Han Chinese population." 04/06/2009 - "2',3'-Cyclic nucleotide 3'-phosphodiesterase (CNP), one of the promising candidate genes for schizophrenia, plays a key part in the oligodendrocyte function and in myelination. " 02/01/2008 - "The A-allele of rs2070106 within the 2',3'-cyclic nucleotide 3'-phosphodiesterase (CNP), an oligodendrocyte-related gene, was reported to show reduced expression compared with the G-allele, and proposed to be associated with schizophrenia. " 02/01/2008 - "Effect of a functional single nucleotide polymorphism in the 2',3'-cyclic nucleotide 3'-phosphodiesterase gene on the expression of oligodendrocyte-related genes in schizophrenia."
2.	Glaucoma 10/03/2022 - "The purpose of this study was to test if optic nerve head (ONH) myelin basic protein (MBP), 2',3'-cyclic nucleotide 3'-phosphodiesterase (CNPase), glial fibrillary acidic protein (GFAP), and ionized calcium binding adaptor molecule 1 (Iba1) proteins are altered in non-human primate (NHP) early/moderate experimental glaucoma (EG). "
3.	Demyelinating Diseases (Demyelinating Disease) 11/01/2009 - "Induction of 2',3'-cyclic nucleotide 3'-phosphodiesterase in demyelination of BALB/c mice caused by Angiostrongylus cantonensis." 08/01/2007 - "We show that 2',3'-cyclic nucleotide 3'-phosphodiesterase (CNP) promoter-driven overexpression of human EGFR (hEGFR) accelerated remyelination and functional recovery following focal demyelination of mouse corpus callosum. " 01/01/1984 - "2',3'-Cyclic nucleotide 3'-phosphodiesterase activity in the cerebrospinal fluid of patients with demyelinating diseases." 12/15/2023 - "Lactation also increased the expression of myelin markers involved in the initial stage of myelin recovery (Myelin-associated glycoprotein and 2',3'-cyclic nucleotide 3'-phosphodiesterase) and reduced the demyelination injury. " 11/09/2001 - "The effects of PDGF were significant after 2 weeks: the number of oligodendrocytes (OL) expressing 2',3'-cyclic nucleotide 3'-phosphodiesterase in the lesion increased by 49%, mature OL labelled by in situ hybridization for myelin basic protein-mRNA increased by 27% (P<10(-2)), and the total volume of demyelination decreased by 60% compared to controls. "
4.	Multiple Sclerosis 09/01/2002 - "T cell response to 2',3'-cyclic nucleotide 3'-phosphodiesterase (CNPase) in multiple sclerosis patients." 01/01/1984 - "Simultaneous measurement of 2':3' cyclic-nucleotide 3' phosphodiesterase and RNase activities in sera and spinal fluids of multiple sclerosis patients." 01/01/1983 - "The specific activities of 2',3'-cyclic nucleotide 3'-phosphodiesterase (CNPase, EC3.1.4.37) in erythrocyte membranes from five patients with active multiple sclerosis (MS) and five normals were compared. " 12/01/2013 - "OL-specific proteins, such as myelin basic protein (MBP) and 2',3'-cyclic nucleotide 3'-phosphodiesterase (CNP), as well as other proteins involved in multiple sclerosis and schizophrenia were also identified and are discussed. "
5.	Hypothyroidism 12/01/2000 - "The effects of hypothyroidism on oligodendroglial differentiation and myelination are for the first time studied by immunohistochemical localization of an early oligodendroglial marker, the 2'3'cyclic nucleotide 3'phosphodiesterase (E.C. 3.1.4.37-CNPase), in developing rats. " 12/01/2009 - "Offspring exposed to TBBPA showed dose-unrelated slight decreases of serum triiodothyronine (T(3)) concentration at postnatal day 20, and there was no evidence of hypothyroidism-related neuronal mismigration and impaired oligodendroglial development as judged by morphometric analyses of NeuN-immunoreactive neuronal distribution in the hippocampal CA1, and area of corpus callosum as well as density of 2',3'-cyclic nucleotide 3'-phosphodiesterase (CNPase)-immunoreactive oligodendrocytes in the cingulate deep cortex at the adult stage. " 04/01/2007 - "In the present work, we describe the distribution of 2',3'-cyclic nucleotide 3'-phosphodiesterase (CNPase), myelin basic protein (MBP) and proteolipid protein (PLP) throughout the central myelin sheath of a hypothyroidism model. "

Related Drugs and Biologics

1.	Proteins (Proteins, Gene)
2.	Myelin-Associated Glycoprotein
3.	2',3'-Cyclic-Nucleotide Phosphodiesterases (2',3' Cyclic Nucleotide Phosphodiesterase)
4.	Myelin Basic Protein
5.	Transcription Factors (Transcription Factor)
6.	Glial Fibrillary Acidic Protein
7.	Calcium
8.	Myelin Proteolipid Protein
9.	Messenger RNA (mRNA)
10.	Myelin Proteins