Oxaloacetic Acid (Oxalacetic Acid)

A dicarboxylic acid ketone that is an important metabolic intermediate of the CITRIC ACID CYCLE. It can be converted to ASPARTIC ACID by ASPARTATE TRANSAMINASE.

Also Known As:

Oxalacetic Acid; 2-Ketosuccinic Acid; 2-oxo-Butanedioic Acid; Ketosuccinic Acid; Oxaloacetate; 2 Ketosuccinic Acid; 2 oxo Butanedioic Acid; Acid, Oxalacetic; Acid, Oxaloacetic; Butanedioic acid, 2-oxo-

Networked: 291 relevant articles (13 outcomes, 21 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Carboxylic Acids: 973
  - Keto Acids: 203
    - Oxaloacetates: 3
      - Oxaloacetic Acid: 291
  - Acyclic Acids
    - Dicarboxylic Acids: 108
      - Oxalates: 2497
        Oxaloacetates: 3
        Oxaloacetic Acid: 291

Experts

1.	Campos, Francisco: 9 articles (01/2017 - 06/2011)
2.	Castillo, José: 9 articles (01/2017 - 06/2011)
3.	Sobrino, Tomás: 8 articles (01/2017 - 06/2011)
4.	Teichberg, Vivian I: 8 articles (01/2015 - 01/2007)
5.	Shapira, Yoram: 6 articles (10/2012 - 01/2007)
6.	Zlotnik, Alexander: 6 articles (10/2012 - 01/2007)
7.	Pérez-Mato, María: 5 articles (01/2016 - 06/2011)
8.	Liu, Yang: 4 articles (10/2021 - 01/2013)
9.	Cantley, Lewis C: 4 articles (12/2020 - 01/2018)
10.	Lyssiotis, Costas A: 4 articles (12/2020 - 01/2018)

Related Diseases

1.	Body Weight (Weight, Body) 01/01/2002 - "At 96 h post-surgery, the ratio of the weight of the nonligated lobe to body weight was significantly higher in group III than in group I and group II, and induction of the MIB-5 labeling index showed maximum levels in group III. However, quantitative determination of serum glutamic-oxaloacetate transaminase (GOT) showed peak levels in group II at 24 h after surgery. " 01/09/2019 - "Body weight, glutamate oxaloacetate transaminase, glutamic-pyruvic transaminase, liver histology, and kidney histology were similar when the wild-type/AD animal model mice with and without GA treatment were compared. " 02/01/2015 - "In vivo, oral feeding of CCF (100mg and 500mg/kg of body weight) to rats for five consecutive days before a single dose of t-BHP (2mmol/kg, i.p.) showed a significant (p<0.05) protective effect by lowering serum levels of glutamate oxaloacetate transaminase (GOT) and glutamate pyruvate transaminase (GPT). " 04/12/2011 - "YGJ remarkably prevented body weight loss and DMN damage in the liver, and it inhibited the elevation of serum glutamate oxaloacetate transaminase (GOT), and glutamic pyruvic transaminase (GPT). " 06/01/1985 - "Subcutaneous injection of 4.5 mmol/kg metabolic body weight (BW0.75) of glycerol or malate reduced food intake significantly, whereas the same doses of dihydroxyacetone or oxaloacetate did not. "
2.	Ischemic Stroke 01/09/2014 - "The aim of this study was to analyze the protective effect of an effective dose of oxaloacetate and the human rGOT1 alone and in combination with a non-effective dose of oxaloacetate in an animal model of ischemic stroke. " 02/01/2012 - "Here we review the recent experimental and clinical results where it is demonstrated the potential applicability of oxaloacetate as a novel and powerful neuroprotective treatment against ischemic stroke." 02/01/2012 - "Oxaloacetate: a novel neuroprotective for acute ischemic stroke." 06/01/2011 - "Neuroprotection by glutamate oxaloacetate transaminase in ischemic stroke: an experimental study." 01/01/2017 - "Here, we test the hypothesis that otherwise neurotoxic glutamate can be productively metabolized by glutamate oxaloacetate transaminase (GOT) to maintain cellular energetics and protect the brain from ischemic stroke injury. "
3.	Traumatic Brain Injuries (Traumatic Brain Injury) 07/01/2009 - "Treatment with oxaloacetate after traumatic brain injury has been shown to decrease blood glutamate levels and protect against the neurotoxic effects of glutamate on the brain. " 01/01/2012 - "The authors demonstrate that the blood glutamate scavengers oxaloacetate and pyruvate provide neuroprotection after traumatic brain injury, expressed both by reduced neuronal loss in the hippocampus and improved neurologic outcomes. " 11/01/2011 - "In previous studies, we have shown that by increasing the brain-to-blood glutamate efflux upon scavenging blood glutamate with either oxaloacetate or pyruvate, one achieves highly significant neuroprotection particularly in the context of traumatic brain injury. " 08/25/2022 - "[Activation of the adenosine A2A receptor at the acute stage of moderate traumatic brain injury enhances the neuroprotective effects of oxaloacetate]." 01/01/2012 - "Effect of glutamate and blood glutamate scavengers oxaloacetate and pyruvate on neurological outcome and pathohistology of the hippocampus after traumatic brain injury in rats."
4.	Critical Illness (Critically Ill) 06/01/2003 - "While, amino acid mixtures of glutamine dipeptides, ornithine alpha-ketoglutarate, asparagine, oxaloacetate, arginine, aspartate and glutamate have been used in a variety of conditions, prospective randomised controlled trials have not consistently demonstrated improved survival with their use in the critically ill patient. "
5.	Subarachnoid Hemorrhage (Aneurysmal Subarachnoid Hemorrhage) 07/01/2012 - "This study investigates the efficacy of blood glutamate scavengers oxaloacetate and pyruvate in the treatment of subarachnoid hemorrhage (SAH) in rats. " 07/01/2012 - "The effect of blood glutamate scavengers oxaloacetate and pyruvate on neurological outcome in a rat model of subarachnoid hemorrhage."

Related Drugs and Biologics

1.	Glutamic Acid (Glutamate)
2.	Transaminases (Aminotransferases)
3.	Pyruvic Acid (Pyruvate)
4.	Alkaline Phosphatase
5.	Urea (Carbamide)
6.	Aspartate Aminotransferases (Aspartate Transaminase)
7.	Alanine Transaminase (SGPT)
8.	Amino Acids
9.	Bilirubin
10.	Cholesterol

Related Therapies and Procedures

1.	Injections
2.	Oral Administration
3.	Intravenous Administration
4.	Warm Ischemia
5.	Prenatal Care (Care, Prenatal)