Trigeminal Nerve Injuries

Traumatic injuries to the TRIGEMINAL NERVE. It may result in extreme pain, abnormal sensation in the areas the nerve innervates on face, jaw, gums and tongue and can cause difficulties with speech and chewing. It is sometimes associated with various dental treatments.

Also Known As:

Cranial Nerve V Injury; Fifth Cranial Nerve Injuries; Fifth Cranial Nerve Injury; Fifth-Nerve Palsy, Traumatic; Fifth-Nerve Trauma; Injury, Cranial Nerve V; Injury, Fifth Cranial Nerve; Traumatic Fifth-Nerve Palsy; Trigeminal Nerve Avulsion; Trigeminal Nerve Contusion; Trigeminal Nerve Injury; Trigeminal Nerve Transection; Trigeminal Nerve Trauma; Trigeminal Neuropathy, Traumatic; Avulsion, Trigeminal Nerve; Avulsions, Trigeminal Nerve; Contusion, Trigeminal Nerve; Contusions, Trigeminal Nerve; Fifth Nerve Palsy, Traumatic; Fifth Nerve Trauma; Fifth-Nerve Palsies, Traumatic; Fifth-Nerve Traumas; Injuries, Trigeminal Nerve; Injury, Trigeminal Nerve; Nerve Avulsion, Trigeminal; Nerve Avulsions, Trigeminal; Nerve Contusion, Trigeminal; Nerve Contusions, Trigeminal; Nerve Injuries, Trigeminal; Nerve Injury, Trigeminal; Nerve Transection, Trigeminal; Nerve Transections, Trigeminal; Nerve Trauma, Trigeminal; Nerve Traumas, Trigeminal; Neuropathies, Traumatic Trigeminal; Neuropathy, Traumatic Trigeminal; Palsies, Traumatic Fifth-Nerve; Palsy, Traumatic Fifth-Nerve; Transection, Trigeminal Nerve; Transections, Trigeminal Nerve; Trauma, Fifth-Nerve; Trauma, Trigeminal Nerve; Traumas, Fifth-Nerve; Traumas, Trigeminal Nerve; Traumatic Fifth Nerve Palsy; Traumatic Fifth-Nerve Palsies; Traumatic Trigeminal Neuropathies; Traumatic Trigeminal Neuropathy; Trigeminal Nerve Avulsions; Trigeminal Nerve Contusions; Trigeminal Nerve Transections; Trigeminal Nerve Traumas; Trigeminal Neuropathies, Traumatic

Networked: 77 relevant articles (6 outcomes, 8 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1.	Pain (Aches)
2.	Hypersensitivity (Allergy)
3.	Neuralgia (Stump Neuralgia)
4.	Chronic Pain
5.	Facial Pain (Myofacial Pain)

Experts

1.	Iwata, Koichi: 6 articles (01/2019 - 01/2011)
2.	Shinoda, Masamichi: 5 articles (01/2019 - 01/2011)
3.	Renton, Tara: 5 articles (08/2017 - 01/2011)
4.	Yilmaz, Zehra: 4 articles (08/2017 - 01/2011)
5.	Westlund, Karin N: 3 articles (12/2020 - 01/2018)
6.	Kitagawa, Junichi: 3 articles (03/2020 - 06/2014)
7.	Katagiri, Ayano: 3 articles (01/2020 - 09/2017)
8.	Renton, T: 3 articles (06/2018 - 11/2010)
9.	Scher, Edwin: 3 articles (08/2017 - 10/2016)
10.	Suzuki, Jon: 3 articles (08/2017 - 10/2016)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Trigeminal Nerve Injuries:

1.	Cholecystokinin B ReceptorIBA 07/03/2023 - "In vivo studies validated the efficacy of the CCK-B receptor (CCK-BR) scFv77-2 antibody as a potential therapy for chronic trigeminal nerve injury-induced pain. "
2.	ManganeseIBA 12/01/2020 - "The manganese-enhanced magnetic resonance imaging (MEMRI) utilized improved MRI signal contrast in brain regions with higher neuronal activity in the rodent chronic constriction trigeminal nerve injury (CCI-ION) model. "
3.	Carbamazepine (Tegretol)FDA LinkGeneric 10/27/2021 - "Mechanisms Underlying the Selective Therapeutic Efficacy of Carbamazepine for Attenuation of Trigeminal Nerve Injury Pain."
4.	ELB00824IBA 03/03/2020 - "ELB00824 provides greatly improved attenuation of pain-related behaviors, including mechanical hypersensitivity, anxiety, and depression in our chronic trigeminal nerve injury models. "
5.	Dental Implants (Dental Implant)IBA 08/01/2017 - "The incidence and cause of iatrogenic trigeminal nerve injury (TNI) related to dental implant surgery was investigated in a survey of the opinion and experience of the UK dentists and reported by the authors in part 1 of this series of articles. " 04/01/2017 - "A Survey of the Opinion and Experience of UK Dentists: Part 2: Risk Assessment Strategies and the Management of Iatrogenic Trigeminal Nerve Injuries Related to Dental Implant Surgery." 10/01/2016 - "A Survey of the Opinion and Experience of UK Dentists: Part 1: The Incidence and Cause of Iatrogenic Trigeminal Nerve Injuries Related to Dental Implant Surgery." 07/01/2010 - "This study analyzed the characteristics of pharmacologic management of trigeminal nerve injury pain after dental implant surgery. " 07/01/2010 - "These results suggest that pharmacologic management can be used for treating trigeminal nerve injury pain after dental implant surgery."
6.	LipopolysaccharidesIBA 10/01/2018 - "We explored the molecular and behavioral effects of a perineural Lipopolysaccharide (LPS)-mediated inflammatory priming on the development and maintenance of painful post-traumatic trigeminal neuropathy (PPTTN) following infra-orbital nerve chronic constriction injury (CCI-IoN) in rats. " 10/01/2018 - "Lipopolysaccharide-mediated inflammatory priming potentiates painful post-traumatic trigeminal neuropathy." 11/10/2010 - "To better understand the contribution of central nervous system (CNS) glial cells in these different pathological conditions, in this study we sought to characterize functional phenotypes of glial cells in response to trigeminal nerve injury (loose ligation of the mental branch), infection (subcutaneous injection of lipopolysaccharide--LPS) and to sterile inflammation (subcutaneous injection of complete Freund's adjuvant--CFA) on the lower lip. "
7.	Ethanol (Ethyl Alcohol)IBA 03/01/2019 - "The present study demonstrates, for the first time, that trigeminal nerve injury, which induces CNOP, is enough to provide novelty seeking behaviour and lead to increasing ethanol intake. " 01/01/2022 - "Preclinical models have demonstrated that chronic pain, including trigeminal nerve injury, increases ethanol consumption throughout extended administration periods. "
8.	Biomarkers (Surrogate Marker)IBA 01/01/2017 - "In this study, the expression and regulation of biomarkers in TGs have been observed in response to trigeminal nerve injury. " 01/01/2017 - "In large, the changes in biomarker expression in TGs after trigeminal nerve injury are similar to that in DRGs after sciatic nerve injury. " 01/01/2017 - "The aim of this study was to investigate the plasticity of biomarkers associated with chronic persistent pain in TGs after trigeminal nerve injury. "
9.	Calcium Channels (Calcium Channel)IBA 03/07/2014 - "To investigate a potential mechanism underlying trigeminal nerve injury-induced orofacial hypersensitivity, we used a rat model of chronic constriction injury to the infraorbital nerve (CCI-ION) to study whether CCI-ION caused calcium channel α2δ1 (Cavα2δ1) protein dysregulation in trigeminal ganglia and associated spinal subnucleus caudalis and C1/C2 cervical dorsal spinal cord (Vc/C2). "
10.	Proteins (Proteins, Gene)FDA Link 03/07/2014 - "To investigate a potential mechanism underlying trigeminal nerve injury-induced orofacial hypersensitivity, we used a rat model of chronic constriction injury to the infraorbital nerve (CCI-ION) to study whether CCI-ION caused calcium channel α2δ1 (Cavα2δ1) protein dysregulation in trigeminal ganglia and associated spinal subnucleus caudalis and C1/C2 cervical dorsal spinal cord (Vc/C2). "

Therapies and Procedures

1.	Therapeutics 12/01/2022 - "Post-traumatic Trigeminal Neuropathy Associated With Endodontic Therapy: A Systematic Review." 07/03/2023 - "In vivo studies validated the efficacy of the CCK-B receptor (CCK-BR) scFv77-2 antibody as a potential therapy for chronic trigeminal nerve injury-induced pain. "
2.	Low-Level Light Therapy (LLLT) 01/01/2020 - "These results suggest that the combined application of OXT and LLLT is effective in relieving the neuropathic pain induced by trigeminal nerve injury."
3.	Nerve Block (Nerve Blocks) 02/01/1990 - "Patients with chronic pain following trigeminal nerve injuries were studied before and after microsurgical repairs using the McGill Pain Language Inventory, sensory reflex testing, and assessment of pain relief from nerve blocks. "
4.	Oral Surgery (Maxillofacial Surgery) 01/01/2015 - "Within the limitations of this study, it may be stated that oral surgery in an outpatient setting of a teaching university hospital resulted in very low rates of trigeminal nerve injuries. " 06/01/2018 - "This retrospective cohort study examined 53 cases of iatrogenic trigeminal nerve injury seen at the Department of Oral and Maxillofacial Surgery, University Hospitals of Leuven between 2013 and 2014 (0.6% among 8845 new patient visits). " 01/01/2015 - "Trigeminal nerve injuries after mandibular oral surgery in a university outpatient setting--a retrospective analysis of 1,559 cases." 04/01/2014 - "A Pubmed search of the English and Spanish language literature from 2000-2012 using the keywords 'oral surgery' or 'trigeminal nerve injuries' or 'lingual nerve injuries' or 'mandibular nerve injuries' was performed. "
5.	Ligation 11/01/2008 - "Partial infraorbital nerve ligation as a model of trigeminal nerve injury in the mouse: behavioral, neural, and glial reactions." 11/10/2010 - "To better understand the contribution of central nervous system (CNS) glial cells in these different pathological conditions, in this study we sought to characterize functional phenotypes of glial cells in response to trigeminal nerve injury (loose ligation of the mental branch), infection (subcutaneous injection of lipopolysaccharide--LPS) and to sterile inflammation (subcutaneous injection of complete Freund's adjuvant--CFA) on the lower lip. "