Mammaglobin A

A secretoglobin that is produced by the MAMMARY GLAND of HUMANS and may be involved in the binding of ANDROGENS and other STEROIDS. The expression of this protein in normal breast epithelium and in human breast cancer has made it an important histological marker.

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Networked: 79 relevant articles (1 outcomes, 9 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Fleming, Timothy P: 12 articles (02/2013 - 05/2002)
2.	Gillanders, William E: 7 articles (02/2016 - 05/2008)
3.	Mohanakumar, T: 7 articles (10/2014 - 05/2003)
4.	Tiriveedhi, Venkataswarup: 6 articles (12/2019 - 05/2011)
5.	Gilje, Bjørnar: 4 articles (07/2014 - 07/2009)
6.	Nordgård, Oddmund: 4 articles (07/2014 - 07/2009)
7.	Tjensvoll, Kjersti: 4 articles (07/2014 - 07/2009)
8.	Goedegebuure, Peter S: 4 articles (02/2013 - 01/2003)
9.	Jaramillo, Andrés: 4 articles (01/2012 - 12/2002)
10.	Dietz, Jill R: 4 articles (08/2008 - 05/2003)

Related Diseases

1.	Breast Neoplasms (Breast Cancer) 01/01/2018 - "Mammaglobin A expression in peripheral blood (PB) of breast carcinoma patients has been evaluated by various studies, but the findings have been inconsistent. " 01/28/2021 - "A known breast cancer marker, mammaglobin-a, was evaluated as a potential candidate for expression on EVs and increased levels in breast cancer. " 01/01/2020 - "Mammaglobin-A (Mam-A), which is overexpressed in most breast carcinomas, has been proposed as a promising target. " 01/01/2019 - "Mammaglobin-A, VEGFR3, and Ki67 in Human Breast Cancer Pathology and Five Year Survival." 01/01/2018 - "The results indicated that plasma mammaglobin A expression was a predictor of poor prognosis for breast carcinoma patients, with an HR of 2.08 (95% CI=1.48-2.91; P<0.0001) for overall survival. "
2.	Neoplasms (Cancer) 03/22/2023 - "To comprehensively study patterns of mammaglobin-A expression, a tissue microarray containing 16,328 samples from 128 different tumor types as well as 608 samples of 76 different normal tissue types was analyzed using immunohistochemistry. " 03/22/2023 - "Our data characterize mammaglobin-A as a highly specific marker for tumors derived from either the breast, female genitals, or salivary gland." 03/22/2023 - "However, other tumors can also express mammaglobin-A. " 03/22/2023 - "Mammaglobin-A Expression Is Highly Specific for Tumors Derived from the Breast, the Female Genital Tract, and the Salivary Gland." 05/14/2019 - "Mammaglobin-A (MamA) is overexpressed in 40-80% of all human breast cancers. "
3.	Neoplasm Metastasis (Metastasis) 09/01/2006 - "Mammaglobin A was detected in 7/39 (17.9%) of patients with verified metastasis. " 02/01/2011 - "In vivo selectivity was determined by i.v. injection of MamAb-680 into mice with mammaglobin-A-positive and -negative mammary fat pad (MFP) tumors; and by peritumoral MFP injection of the targeted imaging probe in mice with spontaneous ALN metastases. " 02/01/2011 - "A mammaglobin-A targeting agent for noninvasive detection of breast cancer metastasis in lymph nodes." 09/01/1999 - "Mammaglobin, a potential marker of breast cancer nodal metastasis." 12/01/2015 - "Mammaglobin A (MGA), mainly expressed in the breast epithelium, is overexpressed in breast cancer, and has been established as a tumor and promissory marker for the early detection of metastasis. "
4.	Carcinoma (Carcinomatosis) 07/02/2013 - "We found significant mammaglobin A, lipophilin A, lipophilin B and RYD5 gene overexpression in ovarian carcinomas compared to normal ovaries. " 10/01/2003 - "We investigated mammaglobin A expression in metastatic carcinomas of lymph nodes from the breast and various other organs and its usefulness in identifying metastatic carcinoma of the breast. " 01/01/2016 - "Mammaglobin 1 (MGB1), a member of the secretoglobin family, is expressed in mammary epithelial tissues and is overexpressed in most mammary carcinomas. " 05/01/2012 - "Mammaglobin A (MG-A) is purportedly useful for detecting metastatic carcinomas suspected to be of breast origin and has been advocated as a useful marker of micrometastasis in sentinel lymph nodes and minimal residual tumor in bone marrow. " 07/02/2013 - "Using quantitative real-time Reverse Transcription PCR we tested 53 ovarian carcinoma and 30 normal ovaries for the expression of 8 genes belonging to the secretoglobin family: mammaglobin A, lipophilin A, lipophilin B, uteroglobin, HIN-1, UGRP-1, RYD5 and IIS. "
5.	Circulating Neoplastic Cells 09/01/2006 - "Mammaglobin A is a highly specific molecular marker for the detection of circulating tumor cells in operable breast cancer, with important prognostic applications." 04/01/2011 - "Human mammaglobin: a superior marker for reverse-transcriptase PCR in detecting circulating tumor cells in breast cancer patients." 05/01/2008 - "To investigate the prognostic value of the molecular detection of circulating tumor cells (CTCs) using three markers [cytokeratin 19 (CK19), mammaglobin A (MGB1), and HER2] in early breast cancer. " 05/01/2008 - "Prognostic value of the molecular detection of circulating tumor cells using a multimarker reverse transcription-PCR assay for cytokeratin 19, mammaglobin A, and HER2 in early breast cancer." 09/01/2006 - "The development and validation of a nested RT-PCR methodology for the detection of Mammaglobin A-mRNA-positive circulating tumor cells in peripheral blood of patients with operable breast cancer and evaluation of its prognostic significance. "

Related Drugs and Biologics

1.	DNA Vaccines
2.	Antigens
3.	Epitopes
4.	Proteins (Proteins, Gene)
5.	Messenger RNA (mRNA)
6.	Complementary DNA (cDNA)
7.	Vascular Endothelial Growth Factor Receptor-3 (Flt 4)
8.	HLA Antigens (Human Leukocyte Antigens)
9.	Antibodies
10.	Mammaglobin A

Related Therapies and Procedures

1.	Therapeutics
2.	Immunotherapy