Fetuin-B

A fetuin subtype that is closely-related to ALPHA-2-HS-GLYCOPROTEIN. Although fetuin-B binds calcium, it is a minor component of SERUM and therefore it may not play a primary role in preventing serum calcium phosphate precipitation.

Also Known As:

Networked: 67 relevant articles (1 outcomes, 18 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Floehr, Julia: 5 articles (01/2021 - 04/2013)
2.	Jahnen-Dechent, Willi: 5 articles (01/2021 - 04/2013)
3.	Chen, Zheng: 5 articles (05/2020 - 12/2017)
4.	Li, Xuejun: 5 articles (05/2020 - 12/2017)
5.	Li, Zhibin: 5 articles (05/2020 - 12/2017)
6.	Lin, Mingzhu: 5 articles (05/2020 - 12/2017)
7.	Liu, Changqin: 5 articles (05/2020 - 12/2017)
8.	Shi, Xiulin: 5 articles (05/2020 - 12/2017)
9.	Wang, Dongmei: 5 articles (05/2020 - 12/2017)
10.	Yang, Shuyu: 5 articles (05/2020 - 12/2017)

Related Diseases

1.	Insulin Resistance 01/01/2021 - "After 6 months of treatment with a GLP-1RA, serum fetuin-B levels in women with MetS decreased following an improvement in metabolism and insulin sensitivity. " 12/01/2017 - "Future studies on the nongenetic determinants of serum fetuin-B concentration to assess if such unmeasured factors may confound the association between fetuin-B and insulin resistance as well as more pathway analysis for this association are warranted." 12/01/2017 - "The regression coefficients for measured and genetically predicted fetuin-B concentrations on HOMA-IR were significantly different (P <.001).This study suggests the association between fetuin-B and insulin resistance may not be causal. " 12/01/2017 - "The aim of this study was to explore the potential causal relationship between fetuin-B and insulin resistance.We" 10/05/2021 - "Our data suggest that Fetuin-B might be a potential mediator of liver-adipose cross talk involved in short- and long-term regulation of adipose insulin sensitivity, especially in the context of diet-induced weight changes. "
2.	Non-alcoholic Fatty Liver Disease 07/01/2019 - "Our study demonstrated that serum fetuin-B had an independent association with NAFLD in patients with T2DM." 11/01/2017 - "Future studies need to elucidate the pathophysiological significance of fetuin B in NAFLD and its potential value as predictor for disease severity." 04/01/2017 - "This study is to evaluate the role of serum fetuin B in nonalcoholic fatty liver disease (NAFLD). " 05/01/2020 - "Multivariable linear regression analyses with adjustment for potential confounding factors, even NAFLD per se, showed that serum Fetuin-B were significantly and positively associated with ba-PWV, with standardized regression coefficients (β) ranging from 0.055 to 0.075 (all p-values ＜0.05) in different models. " 05/01/2020 - "Increasing tertiles of brachial ankle pulse wave velocity (ba-PWV) were significantly associated with higher prevalence of nonalcoholic fatty liver disease (NAFLD) (48.8%, 61.5%, and 70.5% for tertiles of 1-3, respectively, p＜0.001) and serum Fetuin-B (3.85±1.39, 4.09±1.40, and 4.27±1.46 µg/ml, p=0.047). "
3.	Type 2 Diabetes Mellitus (MODY) 07/01/2019 - "Serum fetuin-B level is an independent marker for nonalcoholic fatty liver disease in patients with type 2 diabetes." 01/01/2018 - "We aimed to explore the independent associations and pathways among serum Fetuin-B, nonalcoholic fatty liver disease (NAFLD) and type 2 diabetes (T2D). " 12/01/2015 - "Targeted analysis showed that fetuin B was increased in humans with liver steatosis and patients with type 2 diabetes. " 01/01/2022 - "Hepatokines Fetuin-A and Fetuin-B status in obese Saudi patient with diabetes mellitus type 2." 07/01/2019 - "Previous studies have assessed serum fetuin-B and its relation to nonalcoholic fatty liver disease (NAFLD) and type 2 diabetes mellitus (T2DM) and as a link between them through inducing insulin resistance (IR). "
4.	Obesity 01/01/2022 - "Therefore, our study identifies leptin-STAT3 as an upstream signalling pathway that activates Fetuin B and provides new insights into the pathogenic mechanisms of obesity-related metabolic disorders." 01/01/2022 - "Our previous population-based study demonstrated a significant association between serum Fetuin B and body fat mass in an obese population, which indicates its potential in mediating obesity-related metabolic disorders. " 10/05/2021 - "Circulating Fetuin-B levels correlated significantly with estimates of obesity, hepatic steatosis as well as HOMA-IR, ISIClamp, FFASupp at baseline. " 01/01/2019 - "All hepatokines, except for fetuin B, were significantly different between lean men and men with obesity. " 01/01/2012 - "Our recent proteomic study has shown that plasma protein levels of fetuin-B (Ft-B) and zinc-α2-glycoprotein (ZAG) are significantly elevated in obesity-resistant (OR) rats exposed to a high fat diet. "
5.	Metabolic Diseases (Metabolic Disease) 04/01/2017 - "Recent studies supported the possible role of fetuin B in metabolic diseases. " 01/01/2020 - "Previous studies have suggested that Fetuin-B seems to be a secreted adipokine related to metabolic diseases. " 01/01/2021 - "Previous studies on serum fetuin-B (fetuin-like protein IRL685) have investigated its association with T2DM; however, the reason for the variation in serum fetuin-B and its regulatory factors in metabolic disease remain unclear. " 10/01/2017 - "Recent evidence indicates a pivotal role for fetuin B, one of the cystatin superfamily of cysteine protease inhibitors, in the pathogenesis of metabolic diseases. " 01/01/2020 - "Hepatokines such as fibroblast growth factor 21 (FGF21), leukocyte cell-derived chemotaxin 2 (LECT2), fetuin-A, fetuin-B, and selenoprotein P (SeP) are liver-derived proteins that are modulated by chronic energy status and metabolic disease. "

Related Drugs and Biologics

1.	alpha-2-HS-Glycoprotein
2.	Fetuin-B
3.	Proteins (Proteins, Gene)
4.	Blood Proteins (Serum Proteins)
5.	Glucose (Dextrose)
6.	Adipokines
7.	Triglycerides (Triacylglycerol)
8.	Peptide Hydrolases (Proteases)
9.	Lipids
10.	Enzymes

Related Therapies and Procedures

1.	Resistance Training
2.	Therapeutics