Hyalohyphomycosis

OPPORTUNISTIC INFECTIONS caused by a heterogeneous group of MITOSPORIC FUNGI with clear (hyalo-) HYPHAE in the host. Common causative agents include ACREMONIUM; ASPERGILLUS; CHRYSOSPORIUM; FUSARIUM; PAECILOMYCES; PENICILLIUM; PSEUDALLESCHERIA; SCEDOSPORIUM; and SCOPULARIOPSIS. Normally a dermatomycoses, it can become invasive in the IMMUNOCOMPROMISED HOST.

Also Known As:

Cutaneous Hyalohyphomycosis; Disseminated Hyalohyphomycosis; Invasive Hyalohyphomycosis; Pulmonary Hyalohyphomycosis; Splenic Hyalohyphomycosis; Subcutaneous Hyalohyphomycosis; Cutaneous Hyalohyphomycoses; Disseminated Hyalohyphomycoses; Hyalohyphomycoses; Hyalohyphomycoses, Cutaneous; Hyalohyphomycoses, Disseminated; Hyalohyphomycoses, Invasive; Hyalohyphomycoses, Pulmonary; Hyalohyphomycoses, Splenic; Hyalohyphomycoses, Subcutaneous; Hyalohyphomycosis, Cutaneous; Hyalohyphomycosis, Disseminated; Hyalohyphomycosis, Invasive; Hyalohyphomycosis, Pulmonary; Hyalohyphomycosis, Splenic; Hyalohyphomycosis, Subcutaneous; Invasive Hyalohyphomycoses; Pulmonary Hyalohyphomycoses; Splenic Hyalohyphomycoses; Subcutaneous Hyalohyphomycoses

Networked: 25 relevant articles (0 outcomes, 2 trials/studies)

Disease Context: Research Results

Related Diseases

1.	Phaeohyphomycosis
2.	Aspergillosis
3.	Mucormycosis
4.	Fusariosis
5.	Hematologic Neoplasms (Hematological Malignancy)

Experts

1.	Atzori, Laura: 1 article (01/2021)
2.	Cappai, Riccardo: 1 article (01/2021)
3.	Corbeddu, Marialuisa: 1 article (01/2021)
4.	Ferraguti, Patrizia: 1 article (01/2021)
5.	Ferreli, Caterina: 1 article (01/2021)
6.	Pilloni, Luca: 1 article (01/2021)
7.	Rongioletti, Franco: 1 article (01/2021)
8.	Deore, Vasudha S: 1 article (05/2019)
9.	Lilani, Sunil: 1 article (05/2019)
10.	Paradeshi, Kiran: 1 article (05/2019)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Hyalohyphomycosis:

1.	Spectinomycin (Spectinomycin Hydrochloride)FDA Link 06/01/2004 - "Pulmonary hyalohyphomycosis caused by Fusarium spp in a Kemp's ridley sea turtle (Lepidochelys kempi): an immunohistochemical study." 06/01/2004 - "To describe the microscopic and immunohistochemical findings in a case of pulmonary hyalohyphomycosis in a Kemp's ridley sea turtle (Lepidochelys kempi). "
2.	Voriconazole (Vfend)FDA LinkGeneric 06/01/2015 - "We report a patient, who was eventually diagnosed with an IFI caused by an agent of hyalohyphomycosis, Talaromyces sp. determined via molecular methods and succesfully treated with voriconazole. " 08/01/2010 - "Cutaneous hyalohyphomycosis in a girdled lizard (Cordylus giganteus) caused by the Chrysosporium anamorph of Nannizziopsis vriesii and successful treatment with voriconazole." 12/01/2015 - "When voriconazole was used as single agent for treatment of hyalohyphomycosis and phaeohyphomycosis, an overall response rate was achieved in 94.1% of cases. " 10/01/2014 - "Voriconazole is the first choice for treatment of the majority of aspergillosis, scedosporiasis, fusariosis and other hyalohyphomycoses. " 08/01/2011 - "Cutaneous hyalohyphomycosis caused by Paecilomyces lilacinus successfully treated by oral voriconazole and nystatin packing."
3.	Itraconazole (Sporanox)FDA LinkGeneric 11/01/1999 - "Cutaneous hyalohyphomycosis caused by Paecilomyces lilacinus in an immunocompetent host successfully treated with itraconazole: case report and review." 05/15/2002 - "Progressive cutaneous hyalohyphomycosis due to Paecilomyces lilacinus: rapid response to treatment with caspofungin and itraconazole." 06/01/2005 - "We report herein, for the first time, a case of unusually recalcitrant hyalohyphomycosis of the face due to Acremonium strictum successfully treated with topical 5% imiquimod in an immunocompetent patient, who had failed to respond to various antifungals, including itraconazole, and cryotherapy." 08/01/1998 - "Itraconazole and voriconazole have a broad range of activity against phylogenetically similar agents of hyalohyphomycosis, phaeohyphomycosis, chromoblastomycosis, and mycetoma."
4.	Amphotericin B (Amphotericin)FDA LinkGeneric 05/01/2002 - "apiospermum and Aspergillus sp. This superficial resemblance has a significant impact on clinical outcomes considering the inherent resistance of Scedosporium to amphotericin B, the traditional antifungal of choice for disseminated hyalohyphomycoses." 04/01/1996 - "The clinical course of the hyalohyphomycosis was then rapidly fatal despite institution of amphotericin B therapy." 02/01/2002 - "Amphotericin B has a relatively broad spectrum of action and is useful in treating cases of candidosis, cryptococcosis, histoplasmosis, blastomycosis, paracoccidioidomycosis, coccidioidomycosis, aspergillosis, extracutaneous sporotrichosis and mucormycosis, and some cases of hyalohyphomycosis and phaeohyphomycosis. "
5.	Fluconazole (Zonal)FDA LinkGeneric 05/01/2019 - "Localized Cutaneous Hyalohyphomycosis by Fusarium spp. Over a Postsurgical Scar: Response to Fluconazole."
6.	SteroidsIBA 01/01/2021 - "We describe a case of hyalohyphomycosis in a diabetic man under systemic steroid treatment for a bullous pemphigoid. "
7.	Periodic AcidIBA 03/01/2007 - "Periodic acid-Schiff reagent also stained the fungal elements, thus confirming our diagnosis of pheohyphomycosis and ruling out the possibility of hyalohyphomycosis. "
8.	Nystatin (Mycostatin)FDA LinkGeneric 08/01/2011 - "Cutaneous hyalohyphomycosis caused by Paecilomyces lilacinus successfully treated by oral voriconazole and nystatin packing."
9.	Ketoconazole (Nizoral)FDA LinkGeneric 06/01/2018 - "Ketoconazole may be used as an alternative treatment option for hyalohyphomycosis caused by Purpureocillium lilacinum."
10.	DNA (Deoxyribonucleic Acid)IBA 08/01/1999 - "Random amplified polymorphic DNA (RAPD) fingerprinting was applied to Fusarium solani from a cutaneous hyalohyphomycosis in a loggerhead sea turtle. "

Therapies and Procedures

1.	Cesarean Section (Caesarean Section) 02/01/1996 - "A case of hyalohyphomycosis, caused by Paecilomyces variotii, has been described in a 31-year-old female, who had undergone a cesarean section in her 39th week of pregnancy for a trial of labour. "
2.	Kidney Transplantation 06/01/2017 - "Subcutaneous hyalohyphomycosis due to Purpureocillium lilacinum in an immunocompromised patient after renal transplantation." 09/01/2009 - "Hyalohyphomycosis caused by Paecilomyces lilacinus after kidney transplantation."
3.	Therapeutics 03/01/2023 - "IMDs other than aspergillosis and mucormycosis include hyalohyphomycosis and phaeohyphomycosis, for which there is no standard therapy and the treatment depends on the clinical disease and status of the patient." 04/01/1996 - "The clinical course of the hyalohyphomycosis was then rapidly fatal despite institution of amphotericin B therapy."
4.	Cryotherapy (Therapy, Cold) 06/01/2005 - "Successful treatment of antifungal- and cryotherapy-resistant subcutaneous hyalohyphomycosis in an immunocompetent case with topical 5% imiquimod cream." 06/01/2005 - "We report herein, for the first time, a case of unusually recalcitrant hyalohyphomycosis of the face due to Acremonium strictum successfully treated with topical 5% imiquimod in an immunocompetent patient, who had failed to respond to various antifungals, including itraconazole, and cryotherapy."
5.	Organ Transplantation 02/06/2023 - "To facilitate an understanding of the epidemiology and clinical features of sino-pulmonary hyalohyphomycoses in the context of host immune impairment, we utilized a host-based approach encompassing the following underlying conditions: neutropenia, hematologic malignancy, hematopoietic and solid organ transplantation, chronic granulomatous disease, acquired immunodeficiency syndrome, cystic fibrosis, and healthy individuals who sustain burns, trauma, or iatrogenic exposures. "