Fusariosis

OPPORTUNISTIC INFECTIONS with the soil fungus FUSARIUM. Typically the infection is limited to the nail plate (ONYCHOMYCOSIS). The infection can however become systemic especially in an IMMUNOCOMPROMISED HOST (e.g., NEUTROPENIA) and results in cutaneous and subcutaneous lesions, fever, KERATITIS, and pulmonary infections.

Also Known As:

Disseminated Fusariosis; Fusarium Infection; Invasive Fusariosis; Invasive Pulmonary Fusariosis; Pulmonary Fusariosis; Disseminated Fusarioses; Fusarioses; Fusarioses, Disseminated; Fusarioses, Invasive; Fusarioses, Invasive Pulmonary; Fusarioses, Pulmonary; Fusariosis, Disseminated; Fusariosis, Invasive; Fusariosis, Invasive Pulmonary; Fusariosis, Pulmonary; Fusarium Infections; Infection, Fusarium; Infections, Fusarium; Invasive Fusarioses; Invasive Pulmonary Fusarioses; Pulmonary Fusarioses

Networked: 380 relevant articles (35 outcomes, 23 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1.	Aspergillosis
2.	Infections
3.	Candidiasis (Moniliasis)
4.	Mycoses (Diseases, Fungus)
5.	scedosporiosis

Experts

1.	Kontoyiannis, Dimitrios P: 7 articles (12/2021 - 12/2005)
2.	Nucci, Marcio: 6 articles (01/2021 - 07/2003)
3.	Kamei, Katsuhiko: 5 articles (10/2020 - 01/2014)
4.	Kulma, Anna: 5 articles (01/2020 - 08/2009)
5.	Szopa, Jan: 5 articles (01/2020 - 08/2009)
6.	Karlovsky, Petr: 5 articles (01/2019 - 07/2013)
7.	Wiederhold, Nathan P: 4 articles (07/2021 - 01/2006)
8.	Pawelzik, Elke: 4 articles (02/2016 - 07/2005)
9.	Guo, Shiwei: 3 articles (10/2021 - 04/2014)
10.	Shen, Qirong: 3 articles (10/2021 - 04/2014)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Fusariosis:

1.	Voriconazole (Vfend)FDA LinkGeneric 03/01/2011 - "Voriconazole is also effective in treating fusariosis. " 02/01/2013 - "The efficacy of voriconazole in 24 ocular Fusarium infections." 01/01/2023 - "We report a case of a 4-year-old girl with disseminated fusariosis with persistently undetectable voriconazole troughs. " 01/01/2020 - "Early detection of possible voriconazole resistance is critical for choosing the correct treatment option for patients with invasive fusariosis." 01/01/2018 - "Fusarium Infection in a Kidney Transplant Recipient Successfully Treated with Voriconazole."
2.	posaconazole FDA Link 12/01/2004 - "Posaconazole may provide effective treatment for difficult-to-treat Fusarium infections." 05/15/2006 - "These results suggest that posaconazole is useful for the treatment of invasive fusariosis." 03/01/2010 - "To evaluate the efficacy of posaconazole as treatment or prophylaxis against invasive fusariosis caused by Fusarium solani, we utilized a neutropenic murine model of disseminated disease. " 05/15/2006 - "In this retrospective analysis of patients from 3 open-label clinical trials, we evaluated posaconazole for the treatment of invasive fusariosis. " 04/01/2011 - "We describe two cases of disseminated fusariosis that occurred despite posaconazole prophylaxis."
3.	liposomal amphotericin B FDA Link 01/01/2019 - "The Fusarium infection was finally cured by the administration of liposomal amphotericin B for a total of 19 weeks. " 07/01/2002 - "Efficacy of liposomal amphotericin B in treatment of systemic murine fusariosis." 05/01/1992 - "Efficacy of liposomal amphotericin B (AmBisome) in the eradication of Fusarium infection in a leukaemic patient." 01/01/2019 - "[Successful treatment of pre-engraftment disseminated fusariosis with high-dose liposomal amphotericin B in a cord blood transplant recipient]." 01/01/2006 - "A case of fusariosis in an immunocompromised patient successfully treated with liposomal amphotericin B."
4.	Amphotericin B (Amphotericin)FDA LinkGeneric 09/01/2022 - "This report supports the use of intrathecal amphotericin B for treatment of CNS fusariosis." 01/01/2022 - "Successful treatment of disseminated amphotericin-resistant fusariosis in a paediatric patient with acute lymphoblastic leukaemia: a case report and literature review" 01/01/2011 - "High-dose amphotericin B is recommended for treatment of most cases of fusariosis. " 02/01/1997 - "A correlation study of in-vitro testing with in-vivo outcome of amphotericin B of the cases of disseminated fusarium infections published is reported." 03/01/2011 - "High dose intravenous amphotericin B formulation is recommended as the first line of therapy in management of fusariosis in patients. "
5.	Antifungal AgentsIBA 12/01/2023 - "Additionally, no clear correlation between the in vitro established minimal inhibitory concentrations (MICs) of antifungal agents and clinical outcome has been established for fusariosis. " 06/01/2023 - "Fusarium infection is notoriously difficult to treat, because of their inherently high minimum inhibitory concentrations (MICs) to most antifungal agents. " 12/01/2022 - "solani species complex to the most of modern antifungal agents and the need for novel therapeutic agents against fusariosis has been considered." 10/01/2020 - "The difficulty in treating cases of fusariosis in the human medical clinic exemplifies this situation, because when Fusarium spp. are present in the form of biofilm, the permeation of antifungal agents is compromised. " 02/01/2020 - "A combination of continuous administration of antifungal agents and vigorous surgical intervention may be important for management of disseminated fusariosis in the setting of HSCT."
6.	Proteins (Proteins, Gene)FDA Link 06/22/2021 - "The expression of AsPR1c, d, g, k, AsPR2b, AsPR5a, c (in roots), and AsPR4a(c), b, and AsPR2c (in stems and cloves) significantly differed between garlic cultivars resistant and susceptible to Fusarium rot, suggesting that it could define the PR protein-mediated protection against Fusarium infection in garlic. " 12/01/2004 - "We thus show for the first time the over expression of a high molecular mass protein by mild dose of Cd(2+) pre-exposure to wheat seeds which subsequently provided protection against Fusarium infection. " 09/01/2023 - "Therefore, comparative proteomic approach was employed for identification of proteins released in resistant genotype during Fusarium infection. " 12/09/2022 - "Fusarium infection caused a destructive effects on tomato plant, high severity desiese index 84.37%, reduction in growth parameters, photosynthetic pigments, and soluble protein. " 03/01/2022 - "The results of SDS-PAGE profile revealed variations in the leaves protein profile of the grafted and self- rooted seedlings in response to Fusarium infection. "
7.	NivolumabIBA 01/01/2022 - "Nivolumab induces long-term remission in a patient with fusariosis." 03/01/2023 - "Corrigendum to 'Nivolumab induces long-term remission in a patient with fusariosis' [Eur J Cancer 173 (2022) 91-94]."
8.	MycotoxinsIBA 01/01/2022 - "Although chemical control of Fusarium infection has been applied to grains, it is not always effective in controlling disease or reducing the level of mycotoxins in wheat grains. " 12/27/2017 - "The aim of this research was to study the effect of heavy Fusarium infection with Fusarium culmorum and biosynthesis of mycotoxins on different wheat varieties during malting by setting up field trials with control and Fusarium-inoculated treatments at the Agricultural Institute Osijek. " 08/10/2022 - "DON is one of the big five agriculturally important mycotoxins, resulting from Fusarium infection on grains, such as maize, barley, and wheat. " 01/07/2022 - "The purpose of this review was to evaluate the fusariosis resistance to the main agricultural fungicides, to observe whether this resistance can cause changes in the production of mycotoxins, and to verify the influence of resistance on the cereal grain production chain. " 01/07/2022 - "Fusariosis affects cereal grain crops worldwide and is responsible for devastating crops, reducing grain quality and yield, and producing strong mycotoxins. "
9.	AzolesIBA 10/12/2022 - "Antifungal treatment of fusariosis is often hampered by limited treatment options due to resistance towards azole antifungals. " 12/01/2016 - "Primary antifungal prophylaxis with an antimold azole may prevent the occurrence of invasive fusariosis in high-risk hematologic patients with superficial skin lesions on admission growing Fusarium spp." 12/01/2016 - "We evaluated the impact of primary prophylaxis with a mold-active azole in preventing invasive fusariosis in these patients. " 01/01/2021 - "Invasive fusariosis is a life-threatening fungal infection that is difficult to treat with conventional azole antifungals. " 06/01/2020 - "Fusarium infections are difficult to be treated due to their intrinsic resistance to different azoles; however, accurate and fast identification of etiological agents may enhance management of the infection. "
10.	TriazolesIBA 12/01/2007 - "Voriconazole (VRC) is a triazole shown to be safe, well tolerated, and in vitro efficacious against Fusarium spp. Although clinical experience is limited, many case reports have shown the efficacy of VRC in the treatment of fusariosis." 03/01/2023 - "Efinaconazole, a novel triazole, may be a promising candidate for the treatment of superficial Fusarium infections. " 01/07/2022 - "Benzimidazoles and triazoles were recommended to combat fusariosis; however, there were reports of resistance, making it necessary to reflect on the reasons for this occurrence. " 07/15/2003 - "We report the successful treatment of disseminated Fusarium infection with skin manifestations in a severely neutropenic, immunocompromised host with voriconazole, a new second-generation triazole. " 01/01/2003 - "Posaconazole [SCH 56592, SPRIAFIL, Noxafil] is an orally active triazole derivative that is in phase III trials with the Schering-Plough Research Institute (SPRI) in the US for the treatment of serious opportunistic fungal infections, including aspergillosis, candidiasis, coccidioidomycosis and fusariosis. "

Therapies and Procedures

1.	Therapeutics 12/01/2023 - "Treatment of Fusarium Infection of the Central Nervous System: A Review of Past Cases to Guide Therapy for the Ongoing 2023 Outbreak in the United States and Mexico." 12/01/2023 - "The combination therapy was successful in one patient, however the other patient did not survive the disseminated Fusarium infection." 09/16/2023 - "Because early initiation of intense antifungal therapy offers the best chance for survival in pulmonary fusariosis, computed tomography scans and appropriate microbiologic investigations should be obtained for severely immunocompromised patients." 01/01/2023 - "Fosmanogepix Therapy of Disseminated Fusarium Infection." 09/01/2022 - "Our results are very promising and arouse interest to investigate the action of 4-BFCA on Fusarium strains since it acts as a possible candidate for the development of new therapies for the treatment of fusariosis."
2.	Transplantation 11/11/2022 - "During transplantation, disseminated Fusarium infection occurred, involving the skin, liver, spleen and central nervous system, and the patient eventually died. " 02/01/2020 - "Thereafter, the patient has been well without recurrence of fusariosis for more than 2 years since transplantation. " 05/01/2004 - "The median time period between transplantation and diagnosis of fusariosis was 48 days. " 02/01/2020 - "Long-term survival after cord blood transplantation for acute myeloid leukemia complicated with disseminated fusariosis." 08/01/2018 - "Disseminated fusariosis emerged from prolonged local genital infection after cord blood transplantation."
3.	Lung Transplantation 08/01/2014 - "Airway complication contributing to disseminated fusariosis after lung transplantation." 01/01/2011 - "We studied fusariosis in 6 patients following lung transplantation who were treated at Massachusetts General Hospital during an 8-year period and reviewed 3 published cases in the literature. " 11/01/2013 - "The most important risk factors for invasive fusariosis in our patients were compromised immune system, specifically lung transplantation (n = 6) and hematologic malignancies (n = 5), and burns (n = 7 patients with skin fusariosis), while the most commonly infected site was the skin in 11 of 26 patients. " 03/01/2019 - "We present a case of endobronchial fusariosis following bilateral sequential lung transplantation for idiopathic pulmonary arterial hypertension in a 13 years old boy who was treated successfully with posaconazole and nebulized amphotericin B. "
4.	Leukocyte Transfusion 01/01/1990 - "From this case and from a review of the literature, it appears that synergic antifungal agents combined with leukocyte transfusions may be beneficial in the successful treatment of fusariosis in the compromised host."
5.	Catheters 03/01/2006 - "Of 3 proven IFIs occurring during the study period, only 1, a catheter-related case of disseminated fusariosis, occurred while the subject was receiving study medication. " 11/01/1988 - "Fungemia in disseminated fusariosis may reflect a capacity for invasion of intravascular catheters by Fusarium species. "