Lobomycosis

A chronic, fungal, subcutaneous infection endemic in rural regions in South America and Central America. The causal organism is Lacazia labol.

Also Known As:

Jorge Lobo Disease; Jorge Lobo's Disease; Keloidal Blastomycosis; Lacaziosis; Blastomycoses, Keloidal; Blastomycosis, Keloidal; Disease, Jorge Lobo; Disease, Jorge Lobo's; Disease, Lacaziosis-like; Disease, Lobomycosis-like; Infection, Lacazia loboi; Jorge Lobos Disease; Keloidal Blastomycoses; Lacazia loboi Infections; Lacazioses; Lacaziosis like Disease; Lacaziosis-like Diseases; Lobomycoses; Lobomycosis like Disease; Lobomycosis-like Diseases; Lacazia loboi Infection; Lacaziosis-like Disease; Lobomycosis-like Disease

Networked: 39 relevant articles (0 outcomes, 5 trials/studies)

Disease Context: Research Results

Related Diseases

1.	Leprosy (Hansen's Disease)
2.	Paracoccidioidomycosis (South American Blastomycosis)
3.	Chromoblastomycosis (Chromomycosis)
4.	Lobomycosis
5.	Skin Diseases (Skin Disease)

Experts

1.	Quaresma, Juarez Antonio Simões: 3 articles (01/2020 - 01/2008)
2.	Bossart, Gregory D: 3 articles (08/2015 - 01/2008)
3.	Fair, Patricia A: 3 articles (08/2015 - 01/2008)
4.	Reif, John S: 3 articles (08/2015 - 01/2008)
5.	Lauris, José Roberto Pereira: 3 articles (08/2011 - 07/2004)
6.	Vilani-Moreno, Fátima Regina: 3 articles (08/2011 - 07/2004)
7.	Mendoza, Leonel: 3 articles (08/2009 - 08/2005)
8.	Rosa, Patricia S: 3 articles (08/2009 - 08/2005)
9.	Vilela, Raquel: 3 articles (08/2009 - 08/2005)
10.	Vittor, Amy Y: 2 articles (05/2022 - 11/2020)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Lobomycosis:

1.	CytokinesIBA 07/01/2004 - "The results suggest that patients with Jorge Lobo's disease show altered cytokine profiles represented by a predominance of the Th2 profile. " 07/01/2004 - "Cytokine quantification in the supernatant of mononuclear cell cultures and in blood serum from patients with Jorge Lobo's disease." 01/01/2008 - "The hypothesis of the present paper is explaining the possible mechanism of this cytokine in cutaneous lesions pathology in chromoblastomycosis and lacaziosis (Jorge Lobo's disease). " 02/01/2008 - "Further studies are necessary to better characterize the phenotype of the inflammatory infiltrate as well as the participation of other cytokines and growth factors in the tissue response of the host in Jorge Lobo's disease." 08/01/2011 - "Detection of cytokines and nitric oxide synthase in skin lesions of Jorge Lobo's disease patients."
2.	Intercellular Signaling Peptides and Proteins (Growth Factors)IBA 02/01/2008 - "Further studies are necessary to better characterize the phenotype of the inflammatory infiltrate as well as the participation of other cytokines and growth factors in the tissue response of the host in Jorge Lobo's disease."
3.	HLA Antigens (Human Leukocyte Antigens)IBA 09/01/2005 - "[Study of the association between human leukocyte antigens and Jorge Lobo's disease]." 09/01/2005 - "The result did not show any association between HLA antigens and Jorge Lobo's disease. "
4.	Complement System Proteins (Complement)IBA 03/01/2007 - "Since there are no studies evaluating the participation of the complement system (CS) in Jorge Lobo's disease and its activity on the fungus Lacazia loboi, we carried out the present investigation. "
5.	AntigensIBA 01/01/2008 - "Use of sera from humans and dolphins with lacaziosis and sera from experimentally infected mice for Western Blot analyses of Lacazia loboi antigens." 08/01/2005 - "brasiliensis antigen strongly reacts when it is used to test sera from patients with lacaziosis. " 12/01/1998 - "The majority of lobomycosis serum samples recognized crude exo-antigens and gp43 from P. " 12/01/1998 - "To verify cross-antigenicity between them, lobomycosis sera were tested by immunoblotting, ELISA and capture-EIA against crude exo-antigen, 'cell-free antigen' and gp43 from P. " 07/01/1988 - "The antigenic relationship between both fungi was confirmed by our results based on biopsies from Keloidal blastomycosis and Paracoccidioidomycosis, by using the PAP method and a rabbit serum against a metabolic antigen from Paracoccidioides brasiliensis."
6.	SuspensionsIBA 06/01/2003 - "Both hind foot pads of BALB/c and B10.A mice strains, were inoculated with a fungal suspension of Lacazia loboi obtained from a Jorge Lobo's disease patient. " 09/01/2000 - "Considering the experimental work on paracoccidioidomycosis, 0.03 ml of a fungal suspension obtained from a biopsy of a Jorge Lobo's Disease patient were inoculated into both hind foot pads of 32 six week-old BALB/c mice of both sexes. " 11/01/1999 - "The inocula, consisting of fungal suspensions from biopsies obtained from Jorge Lobo's Disease patients, had the total number of fungi and the viability index determined using a Neubauer chamber and the fluorescein diacetate-ethidium bromide technique (FD-EB), respectively. "
7.	Ketoconazole (Nizoral)FDA LinkGeneric 01/01/1986 - "Lobomycosis in western Brazil: report of a clinical trial with ketoconazole." 07/01/1980 - "Treatment of paracoccidioidomycosis, candidosis, chromomycosis, lobomycosis, and mycetoma with ketoconazole: a brief summary." 09/01/1980 - "The authors present the use of ketoconazole in 27 cases of paracoccidioidomycosis, eight of mycetoma, seven of chromomycosis, four of systemic candidiasis and one of lobomycosis. " 09/01/1980 - "Treatment of paracoccidioidomycosis, candidiasis, chromomycosis, lobomycosis, and mycetoma with ketoconazole."
8.	Glycoproteins (Glycoprotein)IBA 08/01/2016 - "The partial sequence of 43-kDa glycoprotein coding gene confirmed by a nested PCR and sequencing, which revealed a different genotype from both Amazonian and Japanese lacaziosis in bottlenose dolphins, and was 99 % identical to those derived from Paracoccidioides brasiliensis; a sister fungal species to L. " 08/01/2016 - "Detection of Multiple Budding Yeast Cells and a Partial Sequence of 43-kDa Glycoprotein Coding Gene of Paracoccidioides brasiliensis from a Case of Lacaziosis in a Female Pacific White-Sided Dolphin (Lagenorhynchus obliquidens)." 01/01/1976 - "These macrophages in lobomycosis, considered by some in the past to be granular myoblastoma cells, were rich in glycoproteins and appeared to be "Gaucher-like cells" in electronmicrographs. " 08/01/1991 - "43-kilodalton glycoprotein from Paracoccidioides brasiliensis: immunochemical reactions with sera from patients with paracoccidioidomycosis, histoplasmosis, or Jorge Lobo's disease."
9.	DNA (Deoxyribonucleic Acid)IBA 08/01/2009 - "loboi was obtained from proven cases of lacaziosis and 14 collections were maintained in mice, the others were analyzed from DNA taken directly from infected human tissue.). " 10/01/1998 - "Fungal-specific primers targeted for highly conserved genomic nucleic acid sequences were used in a polymerase chain reaction (PCR) to amplify DNA from lobomycosis lesions in a bottlenose dolphin. "
10.	AntibodiesIBA 01/01/1993 - "Sera from 50 patients with paracoccidioidomycosis had PHA titres of > 1/800, and had antibodies detectable by immunodiffusion while antibodies to gp43 were detectable by PHA in sera from patients with histoplasmosis, aspergillosis, candidiasis, Jorge Lobo's disease or healthy people, only at titres of < 1/100. " 01/01/2008 - "Antibodies in the sera of patients with lacaziosis recognized an approximately 193-kDa antigen and other Lacazia loboi antigens. "

Therapies and Procedures

1.	Therapeutics 05/10/2022 - "All relevant studies that addressed epidemiology, diagnosis, or therapeutics of lobomycosis were considered. " 05/10/2022 - "An effective therapy for lobomycosis has been found following decades of research led by the State Dermatology Program of Acre in the Amazon rainforest, where the largest number of cases occur. " 03/01/2010 - "There is still no curative therapy for disseminated lesions of lobomycosis." 11/16/2020 - "Multidrug Therapy for Leprosy Can Cure Patients with Lobomycosis in Acre State, Brazil: A Proof of Therapy Study."
2.	Tattooing 09/23/2009 - "Environmental factors seem to play a role in the emergence and pathogenicity of morbillivirus epidemics, lobomycosis/LLD, toxoplasmosis, poxvirus-associated tattoo skin disease and, in harbour porpoises, infectious diseases of multifactorial aetiology. " 08/20/2015 - "Pathologic diagnoses were: orogenital sessile papilloma (39.7%), cutaneous lobomycosis (16.7%), tattoo skin disease (TSD; 15.4%), nonspecific chronic to chronic-active dermatitis (15.4%), and epidermal hyperplasia (12.8%). "
3.	Drug Therapy (Chemotherapy) 09/01/1990 - "Lobomycosis is resistant to chemotherapy, but in some cases it can successfully be treated by excision. "
4.	VAP-cyclo protocol 01/01/2022 - "A Case of Cutaneous T Cell Lymphoma Masquerading as Keloidal Blastomycosis Treated with CHOP Regimen."