Maintenance Chemotherapy

Treatment designed to help prevent a relapse of a disease following the successful primary treatments (INDUCTION CHEMOTHERAPY and CONSOLIDATION CHEMOTHERAPY) with a long-term low-dose drug therapy.

Also Known As:

Networked: 672 relevant articles (115 outcomes, 113 trials/studies)

Relationship Network

Therapy Context: Research Results

Experts

1.	Rutkowski, Stefan: 7 articles (12/2021 - 05/2009)
2.	Markman, Maurie: 6 articles (03/2015 - 11/2003)
3.	Pietsch, Torsten: 5 articles (04/2017 - 05/2009)
4.	Guo, Qiaojuan: 4 articles (01/2021 - 10/2019)
5.	Lin, Shaojun: 4 articles (01/2021 - 10/2019)
6.	Pan, Jianji: 4 articles (01/2021 - 10/2019)
7.	Xu, Yun: 4 articles (01/2021 - 10/2019)
8.	Gerber, David E: 4 articles (01/2018 - 02/2011)
9.	Massimino, Maura: 4 articles (06/2016 - 05/2008)
10.	von Hoff, Katja: 4 articles (07/2014 - 08/2012)

Related Diseases

1.	Precursor Cell Lymphoblastic Leukemia-Lymphoma (Acute Lymphoblastic Leukemia) 02/15/2008 - "In adults with standard-risk acute lymphoblastic leukemia, the greatest benefit is achieved from a matched sibling allogeneic transplantation in first complete remission, and an autologous transplantation is less effective than conventional consolidation/maintenance chemotherapy in all patients: final results of the International ALL Trial (MRC UKALL XII/ECOG E2993)." 02/01/1995 - "In a retrospective study, the results of maintenance chemotherapy and allogeneic bone marrow transplantation (BMT) for children who reached a second complete remission (CR2) of their acute lymphoblastic leukemia (ALL) were compared. " 05/01/1992 - "Patients achieving complete clinical remission after three courses were given intensive consolidation and maintenance chemotherapy similar to the L10/L17M protocol designed by the Memorial Sloan-Kettering Group for acute lymphoblastic leukemia and lymphoblastic lymphoma. " 01/01/1991 - "If the patients achieved a complete clinical remission (CR) after three courses, they were given intensive consolidation and maintenance chemotherapy based on a protocol that was modified from the L10/L17M regimen of the Memorial Sloan-Kettering group for acute lymphoblastic leukaemia and lymphoblastic lymphoma. " 06/01/2001 - "To determine whether a combination of high-dose therapy and autologous stem-cell transplantation (ASCT) is superior to conventional-dose consolidation and maintenance chemotherapy as postremission therapy in adults with lymphoblastic lymphoma. "
2.	Acute Myeloid Leukemia (Acute Myelogenous Leukemia) 01/01/1989 - "This study, in addition to the few previously reported randomized trials, suggests that early low-dose consolidation adds no benefit to maintenance chemotherapy in acute myeloblastic leukemia once complete remission has been achieved." 07/01/1991 - "Improved cure rate by very early intensification combined with prolonged maintenance chemotherapy in patients with acute myeloid leukemia: data from the AML Cooperative Group." 06/01/1984 - "Twenty patients treated with maintenance chemotherapy for acute nonlymphoblastic leukemia after achieving complete remission were compared with 13 patients who underwent bone marrow transplantation from an HLA-identical sibling. " 06/01/1984 - "A comparison of bone marrow transplantation with maintenance chemotherapy for patients with acute nonlymphoblastic leukemia in first complete remission." 03/01/1983 - "Of 33 patients who had undergone allogeneic bone marrow transplantation during first complete remission of acute nonlymphocytic leukemia, 21 patients have now been followed in continued complete remission for 6-64 mo (median greater than 18 mo) without maintenance chemotherapy. "
3.	Neoplasms (Cancer) 08/07/2023 - "Maintenance chemotherapy (MC) defines the administration of prolonged relatively low-intensity chemotherapy with the aim of "maintaining" tumor complete remission. " 01/01/1987 - "The present patient, in which the tumor had recurred following surgical excision, was treated successfully with a combination of radiation, further surgery, and maintenance chemotherapy. " 02/01/1997 - "In this period thirteen patients with HLA compatible donors were offered allogeneic BMT during the first remission, while 16 patients without HLA-compatible donor were treated with maintenance chemotherapy (Cancer Chemoth Pharmacology 33:359-365, 1994). " 01/11/2018 - "This is a single-institution randomized phase 2 study of maintenance chemotherapy alone vs SAbR followed by maintenance chemotherapy for patients with limited metastatic NSCLC (primary plus up to 5 metastatic sites) whose tumors did not possess EGFR-targetable or ALK-targetable mutations but did achieve a partial response or stable disease after induction chemotherapy. " 02/01/1996 - "A retrospective descriptive study was designed to assess the quality of life (QoL) and psychosocial adjustment in long-term BMT survivors compared with a group of patients with haematological malignancies receiving maintenance chemotherapy (MC), matched for age, post-treatment time, sociodemographic and disease characteristics. "
4.	Leukemia 11/01/2005 - "The majority of patients with acute leukemia enter complete remission following induction therapy, but relapse despite consolidation and maintenance chemotherapy. " 03/01/1979 - "[Treatment of acute childhood leukemia--cessation of maintenance chemotherapy after 3-year complete remission (author's transl)]." 06/01/1983 - "Use of maintenance chemotherapy was associated with a significantly increased chance of remaining disease free (100% of patients surviving leukemia-free versus 17% for patients not receiving maintenance chemotherapy, p = 0.02). " 12/01/1996 - "We compared the outcome of bone marrow transplantation (BMT) with that of maintenance chemotherapy for adults with acute leukemia who achieved first remission in Japanese Red Cross Nagoya First Hospital. " 12/01/1996 - "[Bone marrow transplantation versus maintenance chemotherapy for adult acute leukemia in first remission]."
5.	Ovarian Neoplasms (Ovarian Cancer) 02/01/2002 - "It would be warranted to perform intermittent maintenance chemotherapy for patients with advanced ovarian cancer, if a clinically disease-free status could be achieved after completion of the standard treatment procedure." 01/01/2020 - "An Asian Gynecologic Oncology Group phase III randomized trial was conducted to determine whether maintenance chemotherapy could improve progression-free survival (PFS) in stages III/IV ovarian cancer. " 04/01/2011 - "The results of this study are essentially compatible with those of recent randomized controlled trials(RCTs) evaluating NAC, maintenance chemotherapy, and IDS in advanced ovarian cancer. " 08/01/2006 - "Despite several studies reporting various degrees of success, the role of maintenance chemotherapy in ovarian cancer remains controversial. " 02/01/2002 - "Between 1991 and 1998, 25 patients with stage III or IV ovarian cancer were enrolled in a trial of intermittent maintenance chemotherapy. "

Related Drugs and Biologics

1.	ubenimex
2.	Cisplatin (Platino)
3.	Methotrexate (Mexate)
4.	Bevacizumab (Avastin)
5.	Fluorouracil (Carac)
6.	Cyclophosphamide (Cytoxan)
7.	Mercaptopurine (6 Mercaptopurine)
8.	Vincristine (Oncovin)
9.	Paclitaxel (Taxol)
10.	Carboplatin (JM8)

Related Therapies and Procedures

1.	Drug Therapy (Chemotherapy)
2.	Therapeutics
3.	Bone Marrow Transplantation (Transplantation, Bone Marrow)
4.	Radiotherapy
5.	Induction Chemotherapy