Psychogenic Polydipsia

A clinical disorder characterized by excessive fluid intake (polydipsia); HYPONATREMIA; and POLYURIA in SCHIZOPHRENIA and other psychiatric disorders. Impaired water metabolism in psychogenic polydipsia can result in WATER INTOXICATION.

Also Known As:

Polydipsia, Psychogenic; Polydipsia, Primary; Polydipsias, Primary; Polydipsias, Psychogenic; Primary Polydipsia; Primary Polydipsias; Psychogenic Polydipsias

Networked: 156 relevant articles (5 outcomes, 7 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1.	Diabetes Insipidus
2.	Neurogenic Diabetes Insipidus (Central Diabetes Insipidus)
3.	Water Intoxication
4.	Central Pontine Myelinolysis
5.	Polyuria

Experts

1.	Christ-Crain, Mirjam: 13 articles (05/2022 - 01/2016)
2.	Winzeler, Bettina: 9 articles (01/2022 - 01/2017)
3.	Vogt, Deborah R: 5 articles (05/2022 - 01/2019)
4.	Sailer, Clara O: 5 articles (01/2022 - 01/2018)
5.	Refardt, Julie: 5 articles (10/2021 - 12/2018)
6.	Fenske, Wiebke: 5 articles (12/2018 - 01/2009)
7.	Goldman, Morris B: 3 articles (01/2020 - 12/2004)
8.	Fassnacht, Martin: 3 articles (01/2019 - 05/2011)
9.	Schrier, Robert W: 3 articles (09/2007 - 11/2003)
10.	Szinnai, Gabor: 2 articles (05/2022 - 01/2019)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Psychogenic Polydipsia:

1.	Vasopressins (Vasopressin)IBA 03/01/1968 - "These studies appear to rule out osmotic diuresis, accumulation of exogenous vasopressin, persistent primary polydipsia, or delay in the induction of membrane permeability as causes for the concentrating defect. " 12/01/2023 - "Primary polydipsia is characterized by excessive fluid intake which may suppress vasopressin levels. " 09/01/1999 - "We describe 4 dogs with primary polydipsia, diagnosed on the basis of a modified water deprivation test, in which further examination included serial measurements of urine osmolality (UOsm) and plasma vasopressin (VP) measurements during water deprivation and hypertonic saline infusion. " 09/01/1999 - "Disturbed vasopressin release in 4 dogs with so-called primary polydipsia." 06/01/1998 - "His response to vasopressin treatment suggested a concomitant presence of primary polydipsia. "
2.	Arginine Vasopressin (Argipressin)IBA 11/16/2023 - "Distinguishing between arginine vasopressin (AVP) deficiency and primary polydipsia is challenging. " 12/01/1984 - "We eliminated the possibility of central diabetes insipidus (DI) and primary polydipsia, and established the presence of nephrogenic DI on the basis of: 1) the interrelationships between plasma osmolality, urine osmolality, and urinary AVP; and 2) impaired antidiuretic responses to AVP and 1 deamino-8-D-arginine vasopressin. " 06/01/2015 - "The water deprivation test and a potential role for the arginine vasopressin precursor copeptin to differentiate diabetes insipidus from primary polydipsia." 06/01/1999 - "In the patients with psychogenic polydipsia, plasma arginine vasopressin and urinary osmolality were as low as those in the patients with central diabetes insipidus. " 01/01/2020 - "In primary polydipsia pathologically high levels of water intake physiologically lower arginine vasopressin (AVP) secretion, and in this way mirror the secondary polydipsia in diabetes insipidus in which pathologically low levels of AVP (or renal responsiveness to AVP) physiologically increase water intake. "
3.	Clozapine (Clozaril)FDA LinkGeneric 12/01/2007 - "[Successful clozapine treatment of primary polydipsia associated with hyponatraemia in a schizophrenic patient. " 07/01/2002 - "Efficacy of clozapine in a non-schizophrenic patient with psychogenic polydipsia and central pontine myelinolysis." 06/01/1991 - "Effect of clozapine on psychogenic polydipsia in chronic schizophrenia." 09/01/1998 - "Rhabdomyolysis after correction of hyponatremia due to psychogenic polydipsia possibly complicated by clozapine." 07/01/2006 - "We report on a case of rhabdomyolysis induced by the correction of hyponatremia after psychogenic polydipsia and clozapine use, where the switch to a high dose of olanzapine resulted in the non-recurrence of rhabdomyolysis. "
4.	Propranolol (Inderal)FDA LinkGeneric 01/01/1998 - "Is propranolol effective in primary polydipsia?" 04/01/1991 - "The successful treatment of psychogenic polydipsia and water intoxication with propanolol. "
5.	Drinking WaterIBA 06/25/2017 - "Compulsive water drinking or psychogenic polydipsia is now increasingly seen in psychiatric populations. " 05/01/2017 - "However, positron emission tomography revealed basal ganglia hypometabolism indicating that primary polydipsia with compulsive water drinking is neurobiologically related to OCD. " 05/01/1987 - "Psychogenic polydipsia is an uncommon clinical disorder characterized by excessive water-drinking in the absence of a physiologic stimulus to drink. " 04/01/1980 - "Psychogenic polydipsia (compulsive water drinking) has until recently been considered a relatively benign process. " 12/01/1968 - "Primary polydipsia--compulsive water drinking. "
6.	Olanzapine (Zyprexa)FDA Link 12/01/2004 - "Absence of effect of olanzapine on primary polydipsia: results of a double-blind, randomized study." 05/20/2020 - "Clinicians should be aware of the association between olanzapine and hyponatremia secondary to SIADH or psychogenic polydipsia. " 07/01/2006 - "We report on a case of rhabdomyolysis induced by the correction of hyponatremia after psychogenic polydipsia and clozapine use, where the switch to a high dose of olanzapine resulted in the non-recurrence of rhabdomyolysis. " 02/01/2001 - "Treatment of psychogenic polydipsia: comparison of risperidone and olanzapine, and the effects of an adjunctive angiotensin-II receptor blocking drug (irbesartan)."
7.	Aquaporin 2IBA 01/01/2000 - "Suppressed urinary excretion of aquaporin-2 in an infant with primary polydipsia." 06/01/1999 - "Urinary excretion of aquaporin-2 water channel differentiates psychogenic polydipsia from central diabetes insipidus." 06/01/1999 - "The present study was undertaken to determine whether urinary excretion of aquaporin-2 (AQP-2) water channel under ad libitum water intake is of value to differentiate polyuria caused by psychogenic polydipsia from central diabetes insipidus. " 11/01/2018 - "AQP2 = aquaporin-2; AVP = vasopressin; CDI = central diabetes insipidus; cCDI = complete central diabetes insipidus; DDAVP = desmopressin; DI = diabetes insipidus; IQR = interquartile range; MRI = magnetic resonance imaging; Na+ = sodium; NDI = nephrogenic diabetes insipidus; pCDI = partial central diabetes insipidus; PP = primary polydipsia; PPS = polyuria-polydipsia syndrome; S_osm = serum osmolality; U_osm = urine osmolality; WDT = water deprivation test."
8.	Aquaporins (Water Channels)IBA 11/01/2003 - "Effect of primary polydipsia on aquaporin and sodium transporter abundance." 06/01/1999 - "Urinary excretion of aquaporin-2 water channel differentiates psychogenic polydipsia from central diabetes insipidus." 06/01/1999 - "The present study was undertaken to determine whether urinary excretion of aquaporin-2 (AQP-2) water channel under ad libitum water intake is of value to differentiate polyuria caused by psychogenic polydipsia from central diabetes insipidus. " 09/01/2007 - "This review discusses the renal aquaporin water channels in the urinary dilution and concentrating defects in cardiac failure, cirrhosis, syndrome of inappropriate hormone secretion, pregnancy, hypothyroidism, isolated glucocorticoid deficiency, isolated mineralocorticoid deficiency, primary polydipsia, acquired and genetic nephrogenic diabetes insipidus."
9.	Chlorothiazide FDA LinkGeneric 07/15/1966 - "[Studies on the mechanism of chlorothiazide antidiuresis in diabetes insipidus and psychogenic polydipsia]." 01/01/1961 - "Action of chlorothiazide administered in cases of diabetes insipidus and psychogenic polydipsia." 01/01/1961 - "[Effect of chlorothiazide on diabetes insipidus and psychogenic polydipsia]."
10.	Sodium Chloride FDA LinkGeneric 01/01/2022 - "A total of 54 euvolemic participants, including 20 healthy individuals and 34 patients with primary polydipsia, received a subcutaneous injection of dulaglutide (Trulicity) 1.5 mg and placebo (0.9% sodium chloride) once weekly over a 3-week treatment phase. " 10/15/2021 - "The aim of this trial was to investigate whether GLP-1 receptor agonists reduce fluid intake in patients with primary polydipsia.MethodsIn this randomized, double-blind, placebo-controlled, 3-week crossover trial, 34 patients with primary polydipsia received weekly dulaglutide (1.5 mg, Trulicity) in one treatment segment and placebo (0.9% sodium chloride) in the other. "

Therapies and Procedures

1.	Therapeutics 01/01/2018 - "Comment on: Sailer C, et al. Primary polydipsia in the medical and psychiatric patient: characteristics, complications and therapy." 01/01/2018 - "Reply to comment on: Sailer CO, et al. Primary polydipsia in the medical and psychiatric patient: characteristics, complications and therapy." 01/01/2017 - "Primary polydipsia in the medical and psychiatric patient: characteristics, complications and therapy." 06/01/1975 - "[Contribution to the therapy of primary polydipsia (author's transl)]." 09/08/1983 - "Diabetes insipidus renalis and psychogenic polydipsia should be ruled out before this therapy is started."
2.	Drug Therapy (Chemotherapy) 06/25/2017 - "Here we present a 35-year old adult who was diagnosed with psychogenic polydipsia and was successfully managed with a combination of pharmacotherapy, fluid restriction and psychosocial management. " 11/20/2021 - "Non-antipsychotic pharmacotherapy of psychogenic polydipsia: A systematic review."
3.	Liver Transplantation 10/01/2013 - "Rapid correction of hyponatremia has been attributed as a most common factor, but alcoholism, malnutrition, prolonged use of diuretics, psychogenic polydipsia, post liver transplant and hypokalemia have also been attributed as a causative factor. "
4.	Length of Stay 07/01/2014 - "Patients with hyper-CKemia in the setting of diuretic-associated hyponatremia were older and had longer hospital length of stay compared with primary-polydipsia-associated. "
5.	Subcutaneous Injections 01/01/2022 - "A total of 54 euvolemic participants, including 20 healthy individuals and 34 patients with primary polydipsia, received a subcutaneous injection of dulaglutide (Trulicity) 1.5 mg and placebo (0.9% sodium chloride) once weekly over a 3-week treatment phase. "