Metronomic Administration

Administration of low doses of a drug or a drug combination over prolonged periods of time usually at a regular interval.

Also Known As:

Administration, Metronomic; Metronomic Drug Administration; Metronomic Drug Therapy; Administrations, Metronomic; Drug Administration, Metronomic; Drug Administrations, Metronomic; Drug Therapies, Metronomic; Drug Therapy, Metronomic; Metronomic Administrations; Metronomic Drug Administrations; Metronomic Drug Therapies

Networked: 26 relevant articles (4 outcomes, 6 trials/studies)

Relationship Network

Therapy Context: Research Results

Therapeutics: 1158551
- Drug Therapy: 293145
  - Drug Administration Schedule: 28
    - Metronomic Administration: 26

Experts

1.	Cazzaniga, Marina Elena: 2 articles (05/2021 - 01/2019)
2.	Kerbel, Robert S: 2 articles (03/2012 - 09/2011)
3.	Man, Shan: 2 articles (03/2012 - 09/2011)
4.	Xu, Ping: 2 articles (03/2012 - 09/2011)
5.	Capici, Serena: 1 article (05/2021)
6.	Cerrito, Maria Grazia: 1 article (05/2021)
7.	Cogliati, Viola: 1 article (05/2021)
8.	Cordani, Nicoletta: 1 article (05/2021)
9.	Riva, Francesca: 1 article (05/2021)
10.	Calvani, Nicola: 1 article (01/2021)

Related Diseases

1.	Neoplasms (Cancer) 01/01/2019 - "Metronomic administration of oral chemotherapy is therefore a promising treatment strategy for some patients with mBC and inhibits tumor progression via multiple mechanisms of action. " 09/01/2017 - "Longitudinal in vivo studies with CPA (140 mg/kg) or TMZ (range 140-240 mg/kg) metronomic administration (every 6 days) were performed in tumor-bearing mice. " 01/01/2021 - "Low-dose metronomic administration of chemotherapy with different drugs and schedules has emerged in the last years as a possible alternative to conventional chemotherapy, due to its promising tumor control rates and excellent safety profiles. " 01/01/2018 - "Here, we apply mathematical modeling to simulate tumor response to multiple drug regimens, with the capability to assess maximum tolerated dose (MTD) as well as metronomic drug administration. " 01/01/2013 - "NGR-SSL-PTX is able to improve treatment efficacy producing the most significant anti-tumor activity and anti-angiogenic following metronomic administration."
2.	Glioma (Gliomas) 07/01/2006 - "To overcome the problem that most of these tumors become resistant to chemotherapeutic regimens within a year, we investigated the antitumor efficacy of metronomic administration of low-dose TMZ in in vitro cell proliferation/cytotoxicity assay and in vivo rat and nude mouse orthotopic glioma model. " 09/01/2010 - "In this study, we evaluated another mechanism of action, angiosuppression by CPT-11 of ACNU-resistant gliomas, using a metronomic administration schedule. " 09/01/2010 - "We found that metronomic administration of CPT-11 significantly inhibited malignant glioma growth by inhibiting angiogenesis; this treatment procedure reduced the number of tumor vessels and the area of hypoxic lesions and reduced expression of VEGF and HIF-1alpha, the most important angiogenic factors in gliomas. "
3.	Osteosarcoma (Osteogenic Sarcoma) 01/01/2018 - "The purpose of this study was to determine if metronomic administration of lomustine following palliative radiation therapy (RT) improved length of palliation and therefore survival in dogs with appendicular osteosarcoma compared to treatment with palliative radiation alone. " 01/01/2018 - "Metronomic administration of lomustine following palliative radiation therapy for appendicular osteosarcoma in dogs."
4.	Breast Neoplasms (Breast Cancer) 02/01/2010 - "Metronomic administration of pegylated liposomal-doxorubicin in extensively pre-treated metastatic breast cancer patients: a mono-institutional case-series report." 02/01/2010 - "Metronomic administration of PLD is a feasible and active treatment for extensively pre-treated metastatic breast cancer patients, alternative to classic anthracyclines, balancing clinical efficacy with a good quality of life in terms of reduced side effects and low personal costs for the patient." 03/01/2012 - "Here we report results evaluating the properties of metronomic administration of an oral prodrug of gemcitabine LY2334737 in nontumor-bearing mice and in preclinical models of human ovarian (SKOV3-13) and breast cancer (LM2-4) xenografts. " 01/01/2011 - "The aim of this study was to examine the efficacy and cardiotoxicity of metronomic administration of two of the most commonly used anticancer agents, cyclophosphamide (CPA) and doxorubicin (DOX), on an experimental breast cancer of rats. "
5.	Prostatic Neoplasms (Prostate Cancer) 09/15/2010 - "Metronomic administration of zoledronic acid and taxotere combination in castration resistant prostate cancer patients: phase I ZANTE trial." 01/01/2023 - "Metronomic Administration of Topotecan Alone and in Combination with Docetaxel Inhibits Epithelial-mesenchymal Transition in Aggressive Variant Prostate Cancers."

Related Drugs and Biologics

1.	Lomustine (CCNU)
2.	Liposomes (Liposome)
3.	Cyclophosphamide (Cytoxan)
4.	Paclitaxel (Taxol)
5.	Docetaxel (Taxotere)
6.	CD13 Antigens (Alanine Aminopeptidase)
7.	Nimustine
8.	Doxorubicin (Adriamycin)
9.	Antineoplastic Agents (Antineoplastics)
10.	Zoledronic Acid (Zometa)

Related Therapies and Procedures

1.	Radiotherapy
2.	Drug Therapy (Chemotherapy)
3.	Castration
4.	Therapeutics