Nuclear Receptor Coactivators

Proteins that enhance gene expression when associated with ligand bound activated NUCLEAR RECEPTORS. The coactivators may act through an enzymatic process that affects the rate of transcription or the structure of chromatin. Alternatively nuclear receptor coactivators can function as adaptor proteins that bring nuclear receptors into close proximity with transcriptional complexes.

Networked: 12 relevant articles (1 outcomes, 0 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	O'Malley, Bert W: 3 articles (06/2010 - 06/2006)
2.	Hong, Kai: 1 article (01/2020)
3.	Lin, Shujun: 1 article (01/2020)
4.	Lin, Wenshan: 1 article (01/2020)
5.	Lin, Zhijun: 1 article (01/2020)
6.	Luo, Yuanyuan: 1 article (01/2020)
7.	Shen, Weitao: 1 article (01/2020)
8.	Xie, Weiji: 1 article (01/2020)
9.	Zhong, Zhiqing: 1 article (01/2020)
10.	Zhou, Tianbiao: 1 article (01/2020)

Related Diseases

1.	Heart Failure 05/16/2018 - "Thus, cumulative evidence suggests that PIMT functions in cardiac energy metabolism by interacting with nuclear receptor coactivators and this property could be useful in the management of heart failure."
2.	Neoplasms (Cancer) 06/15/2010 - "Crosstalk among nuclear receptor coactivators and a membrane receptor promotes tumor cell growth and migration." 05/01/2001 - "The various groups of histone acetyltransferases (CBP/p300, GNAT, MYST, nuclear receptor coactivators and TAFII250) and histone deacetylases are surveyed with regard to their possible or known involvement in cancer progression and human developmental disorders. " 01/01/2013 - "Taken together, these data suggest that the Ets1-dependent estradiol sensitization of breast cancer cells and tumors may be partially due to the ability of Ets1 to cooperate with ERα and nuclear receptor coactivators to stimulate transcriptional activity of estrogen-dependent genes. "
3.	Breast Neoplasms (Breast Cancer) 04/01/2008 - "Overexpression of nuclear receptor coactivators is a frequent event in breast cancer cells and is recognized as a key mechanism for these cells to maximize their oncogenic growth state. " 02/01/2011 - "Elevated expression of steroid receptor coactivator-3 (SRC-3), a member of the p160 family of nuclear receptor coactivators, has been implicated in tamoxifen resistance of breast tumors while the involvement of the two other members of this family, SRC-1 and SRC-2, is less well characterized. " 01/01/2013 - "Taken together, these data suggest that the Ets1-dependent estradiol sensitization of breast cancer cells and tumors may be partially due to the ability of Ets1 to cooperate with ERα and nuclear receptor coactivators to stimulate transcriptional activity of estrogen-dependent genes. "
4.	Carcinogenesis 06/07/2006 - "Steroid receptor coactivator 3 (SRC-3/ACTR/AIB-1/pCIP/RAC3/TRAM-1) is a member of the p160 family of nuclear receptor coactivators that plays an important role in mammary gland growth, development, and tumorigenesis. " 06/29/2001 - "Human breast tumorigenesis is promoted by the estrogen receptor pathway, and nuclear receptor coactivators are thought to participate in this process. "
5.	Chronic Renal Insufficiency 01/01/2020 - "Association of Nuclear Receptor Coactivators with Hypoxia-Inducible Factor-1α in the Serum of Patients with Chronic Kidney Disease."

Related Drugs and Biologics

1.	Nuclear Receptor Coactivator 3
2.	Nuclear Receptor Coactivator 1
3.	Histone Acetyltransferases (Histone Acetyltransferase)
4.	Tamoxifen
5.	Steroid Receptors (Steroid Receptor)
6.	Estrogen Receptors
7.	Androgen Receptors (Androgen Receptor)
8.	Proteins (Proteins, Gene)
9.	Iodide Peroxidase (Deiodinase)
10.	Histone Deacetylases (Histone Deacetylase)