Amaryllidaceae Alkaloids

Alkaloids derived from TYRAMINE combined with 3,4-dihydroxybenzaldehyde via a norbelladine pathway, including GALANTAMINE, lycorine and crinine. They are found in the AMARYLLIDACEAE plant family.

Also Known As:

Alkaloids, Amaryllidaceae; Amaryllidaceae Alkaloids, Benzazepine-Type; Amaryllidaceae Alkaloids, Galanthamine-Type; Amaryllidaceae Alkaloids, Norbelladine-Type; Benzazepine Type Amaryllidaceae Alkaloids; Galanthamine Type Amaryllidaceae Alkaloids; Norbelladine Type Amaryllidaceae Alkaloids; Benzazepine-Type Amaryllidaceae Alkaloids; Galanthamine-Type Amaryllidaceae Alkaloids; Norbelladine-Type Amaryllidaceae Alkaloids

Networked: 33 relevant articles (0 outcomes, 4 trials/studies)

Bio-Agent Context: Research Results

Experts

1.	van Staden, Johannes: 3 articles (11/2018 - 10/2008)
2.	Evidente, Antonio: 3 articles (01/2018 - 07/2010)
3.	Kornienko, Alexander: 3 articles (01/2018 - 07/2010)
4.	Mathieu, Véronique: 3 articles (01/2018 - 07/2010)
5.	Havelek, Radim: 3 articles (09/2017 - 03/2014)
6.	Nair, Jerald J: 2 articles (11/2018 - 01/2016)
7.	Cahlikova, Lucie: 2 articles (09/2017 - 03/2014)
8.	Kralovec, Karel: 2 articles (09/2017 - 03/2014)
9.	Rezacova, Martina: 2 articles (09/2017 - 03/2014)
10.	Seifrtova, Martina: 2 articles (09/2017 - 03/2014)

Related Diseases

1.	Neoplasms (Cancer) 03/13/2023 - "Molecular docking studies were carried out to illustrate binding orientations of the 30 Amaryllidaceae alkaloids identified in the active site of some molecular targets involved with anti-cancer activity for potential anti-cancer drugs. " 11/15/2018 - "This review focuses on studies which highlight how Amaryllidaceae alkaloids modulate the cell cycle of cancer cells." 09/25/2017 - "Anticancer potential of Amaryllidaceae alkaloids evaluated by screening with a panel of human cells, real-time cellular analysis and Ehrlich tumor-bearing mice." 12/06/2016 - "Crude Amaryllidaceae alkaloids (AAs) extracted from Lycoris radiata are reported to exhibit significant anti-cancer activity. " 10/01/2016 - "In addition, Amaryllidaceae alkaloids have frequently been identified as having promising cytotoxic properties against cancer cell lines. "
2.	Triple Negative Breast Neoplasms 09/06/2022 - "Aiming to find Amaryllidaceae alkaloids against breast cancer, including the highly aggressive triple-negative breast cancer, the phytochemical study of Pancratium maritimum was carried out. "
3.	Colorectal Neoplasms (Colorectal Cancer) 01/01/2022 - "In conclusion, the present study shows that Amaryllidaceae alkaloids decrease phenomena and cytokines associated with colorectal cancer progression, supporting future investigations regarding their potential as multifaceted drug candidates."
4.	Breast Neoplasms (Breast Cancer) 09/06/2022 - "Aiming to find Amaryllidaceae alkaloids against breast cancer, including the highly aggressive triple-negative breast cancer, the phytochemical study of Pancratium maritimum was carried out. "
5.	Alzheimer Disease (Alzheimer's Disease) 05/12/2023 - "A lead example is the >150 Amaryllidaceae alkaloids (AmAs) including galantamine, an FDA-approved treatment for Alzheimer's disease. " 10/13/2020 - "Amaryllidaceae alkaloids possess various biological activities, the most important one being their anti-acetylcholinesterase activity, used for the treatment of Alzheimer's disease. " 01/01/2010 - "Amaryllidaceae alkaloids are extensively studied for their biological activities in several pharmaceutical areas, including, for example, Alzheimer's disease for which galanthamine has already reached the market. " 07/13/2022 - "Galanthamine, a drug from this family, is clinically relevant in treating the neurocognitive disorder, Alzheimer's disease, which underscores the importance of the Amaryllidaceae alkaloids. " 01/27/2023 - "Several Amaryllidaceae alkaloids have shown acetylcholinesterase inhibitory activities and are a promising tool for treating cholinergic disorders such as Alzheimer's disease (AD). "

Related Drugs and Biologics

1.	Phytochemicals
2.	Cytokines
3.	Galantamine (Galanthamine)
4.	Alkaloids
5.	Acetylcholinesterase
6.	hemanthamine
7.	lycorine
8.	Leukocyte L1 Antigen Complex (Calgranulin)
9.	Cholinergic Agents (Cholinergics)
10.	Protein S