An enzyme that catalyzes the HYDROLYSIS of terminal, non-reducing alpha-D-mannose residues in alpha-D-mannosides. The enzyme plays a role in the processing of newly formed N-glycans and in degradation of mature GLYCOPROTEINS. There are multiple isoforms of alpha-mannosidase, each having its own specific cellular location and pH optimum. Defects in the lysosomal form of the enzyme results in a buildup of mannoside intermediate metabolites and the disease ALPHA-MANNOSIDOSIS.
Also Known As:
LAMAN; alpha-D-Mannosidase; Neutral alpha-Mannosidase; alpha Mannosidase B; alpha-D-Mannoside Mannohydrolase; Lysosomal alpha Mannosidase; Mannohydrolase, alpha-D-Mannoside; Mannosidase B, alpha; Neutral alpha Mannosidase; alpha D Mannosidase; alpha D Mannoside Mannohydrolase; alpha Mannosidase; alpha-Mannosidase, Lysosomal; alpha-Mannosidase, Neutral; Lysosomal alpha-Mannosidase