Stilbenes

11/27/2023 - "Of these, cis-stilbenes combretastatins A-4 and A-1 were the most potent, exhibiting in vivo efficacy against a wide variety of tumor types in murine models. "
01/01/2018 - "Here, we have identified a novel synthetic trans-stilbene compound, Z-DAN-11 ((Z)-3-(3, 4-dimethoxyphenyl)-2-(3, 4, 5-trimethoxyphenyl) acrylonitrile) which shows remarkable efficacy in blocking tumor growth and progression both in vitro and in vivo. "
01/01/2017 - "Starting from its potent chemotherapeutic activity against a wide variety of cancers, the stilbene scaffold has been subject to synthetic manipulations with the aim of obtaining new analogues with improved anticancer activity and better bioavailability. "
12/01/2022 - "Thus, in this study, a natural stilbene B10 (3-methoxy 5-hydroxy stilbene) isolated from Cajanus cajan (Pigeon Pea) was screened for its anti-proliferative efficacy against 13 cancer cell lines. "
04/18/2023 - "Herein, we report systematic studies on the antiproliferative activity of selected stilbenes and oxepine derivatives against two cancer cell lines-HCT116 and MCF-7-and two normal cell lines-HEK293 and HDF-A. "

04/28/2023 - "Stilbenes, a Versatile Class of Natural Metabolites for Inflammation-An Overview."
01/01/2023 - "Taken together, we show that the stilbenoids PS and PSMME have anti-inflammatory properties in vivo in the intestine and can be used to alleviate chemically induced intestinal inflammation in Drosophila."
05/15/2019 - "Stilbenes might protect the ALI caused by LPS/d-GalN through inhibiting the negative effectiveness of oxidation stress and inflammation. "
10/01/2012 - "This suggests that the stilbenes from Rheum undulatum rhizomes are good candidates for therapeutic strategies towards inflammation."
03/01/2011 - "The results demonstrate that all three investigated stilbene compounds, especially TMS, exhibit a potent inhibitory effect on inflammation-induced cell-cell adhesion, expression of adhesion molecules and activation of the NF-κB pathway."

06/14/2023 - "In silico identification of novel stilbenes analogs for potential multi-targeted drugs against Alzheimer's disease."
05/01/2023 - "edulis seeds, particularly the stilbene dimers, warrant further investigation as potential neuroprotective candidates in the prevention of cognitive deficits associated with Alzheimer's disease."
05/01/2020 - "Natural stilbenes effects in animal models of Alzheimer's disease."
01/01/2018 - "Polyhydroxy stilbenes have been reported to possess various biological activities, and have potential in the treatment of Alzheimer's disease (AD). "
01/01/2014 - "Optical and SPION-enhanced MR imaging shows that trans-stilbene inhibitors of NF-κB concomitantly lower Alzheimer's disease plaque formation and microglial activation in AβPP/PS-1 transgenic mouse brain."

10/16/2023 - "Overall, these data suggest that the effects of stilbenes on brown adipose tissue thermogenic capacity depend on the metabolic status, and more precisely on the presence or absence of obesity, although further studies are needed to confirm this hypothesis."
07/24/2023 - "Recently, the anti-obesity effect of stilbenes has attracted attention. "
10/01/2013 - "Among them, the stilbene derivatives showed the most potent anti-obesity effects. "
01/01/2013 - "Using stilbene analogs, we investigated the structure of RSV to explain its protective effect against obesity and type 2 diabetes. "
09/01/2016 - "This prompted us to study the influence of piceatannol, a polyhydroxylated stilbene, on the prevention of obesity complications in Zucker obese rats. "

12/01/2014 - "One intent is to hopefully provide a relatively comprehensive resource for clues that may prompt ideas for additional mechanistic studies which might further elucidate and strengthen the role of the stilbene family of compounds in cardiovascular disease and cardioprotection. "
01/01/2023 - "Stilbenes could reduce cardiovascular disease mortality. "
01/01/2018 - "Stilbenoids are also reported to improve cardiovascular disease. "
10/15/2019 - "Stilbenes with well-known antioxidant and antiradical properties are beneficial in different pathologies including cardiovascular diseases. "
05/13/2022 - "The significance of rhubarb-derived extracts and low-molecular specialized rhubarb metabolites of diversified chemical background, e.g., anthraquinones and stilbenes, as potential modulators of human metabolism is highlighted, including the context of cardiovascular disease prevention. "