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Metaproterenol (Alupent)

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A beta-2 adrenergic agonist used in the treatment of ASTHMA and BRONCHIAL SPASM.

Also Known As:

Alupent; Alotec; Astmopent; Boehringer Ingelheim Brand of Metaproterenol Sulfate; GSK Brand of Metaproterenol Sulfate; Metaprel; Metaproterenol Polistirex; Metaproterenol Sulfate; Novartis Brand of Metaproterenol Sulfate; Orciprenaline Sulfate; Orciprenaline; 1,3-Benzenediol, 5-(1-hydroxy-2-((1-methylethyl)amino)ethyl)-

Networked: 259 relevant articles (26 outcomes, 27 trials/studies) for this Drug, Comments

Relationship Network

Drug Context: Research Results

Organic Chemicals: 49
- Amines: 1299
- Alcohols: 342
  - Amino Alcohols: 10
    - Ethanolamines: 7
      - Metaproterenol: 259
        Fenoterol: 581

Experts

1.	Jockenhövel, F: 1 article (12/2012)
2.	Halboos, A: 1 article (12/2012)
3.	Thomas, Dierk: 1 article (07/2010)
4.	Schweizer, Patrick A: 1 article (07/2010)
5.	Katus, Hugo A: 1 article (07/2010)
6.	Becker, Rüdiger: 1 article (07/2010)
7.	Zittermann, Armin: 1 article (10/2009)
8.	Schäffler, Rainer: 1 article (10/2009)
9.	Peters, Brigitte: 1 article (10/2009)
10.	Palacios Argueta, Jorge Roberto: 1 article (10/2009)

Related Diseases

1.	Asthma (Bronchial Asthma) 07/01/1986 - "In conclusion, aerosolized metaproterenol was well tolerated in acute childhood asthma in repeated doses, and it appeared to be associated with prolonged bronchodilation and improved outcome." 03/01/1986 - "OTC metaproterenol will aid improvement in asthma care." 08/01/1999 - "A double blind, randomized trial of two regimens of nebulized metaproterenol was conducted in patients presenting to an Emergency Department with an acute asthma exacerbation. " 06/01/1990 - "The dose-response relationship of single doses of nebulized metaproterenol sulfate 5% inhalant solution was evaluated by placebo-controlled, parallel-group study of 30 children, aged 3 to 6 years old, with stable asthma. " 02/01/1987 - "Double-blind, dose-response study of metaproterenol inhalant solution in children with acute asthma." Order ALL the reference details at left...
2.	Bronchial Spasm 07/01/1995 - "One patient's pulse rate increased to more than 200 beats/min. Although effective in reversing bronchospasm, the side effects of metaproterenol when used in rapid sequence are of major concern." 09/01/1987 - "The dose-related effects of inhaled 5% metaproterenol solution in asthmatic children between the ages of six and 12 years with acute bronchospasm were evaluated. " 01/01/1988 - "In conclusion, metaproterenol is superior to cromolyn in protecting against cold-air-induced bronchospasm." 01/01/1988 - "Inhaled metaproterenol is superior to inhaled cromolyn in protecting against cold-air-induced bronchospasm." 02/01/1994 - "Recent reports suggest that glycopyrrolate is as effective as metaproterenol in the treatment of acute bronchospasm. " Order ALL the reference details at left...
3.	Chronic Obstructive Pulmonary Disease (COPD) 01/29/1996 - "These results suggest that the combination of iprathropium bromide and metaproterenol inhalation solutions offers a potential therapeutic advantage to patients with symptomatic COPD over nebulized metaproterenol alone without the risk of increased side effects." 01/01/1994 - "To investigate the relationship between the emphysematous changes and bronchodilator responses in patients with chronic airflow obstruction (CAO), we studied the correlation between bronchodilator response to 10 mg inhaled metaproterenol and the extent of emphysema, using selective alveolobronchogram (SAB). " 02/01/1986 - "To evaluate comparative bronchodilator efficacy with chronic airflow obstruction (CAO), we randomly administered to ten patients week-long treatments consisting of: inhaled metaproterenol from a metered dose canister (1.30 mg six times a day) and doses of a sustained-release theophylline formulation sufficient to achieve plasma levels of 10-15 micrograms/ml; metaproterenol-placebo; theophylline-placebo; or placebo-placebo. " 04/01/1984 - "In our experience, oxygen and inhaled metaproterenol are effective treatment for exacerbations of COPD." 04/01/1991 - "Thus, ipratropium and metaproterenol similarly improved pulmonary function in COPD patients when stable and during acute exacerbations." Order ALL the reference details at left...
4.	Heart Failure 04/01/1979 - "In acute myocardial failure during anaesthesia or in "low cardiac ouptut" following open heart surgery no improvement in myocardial contractility is obtained by i.v.-application of potassium-canrenoate; at the present there seems no alternative to other positive inotropic agents such as calcium, glucagon, dopamine, orciprenaline and epinephrine." 04/01/1992 - "Premodulation of acute heart failure with membrane protective agents (unithiol, alpha-tocopherol, hydrocortisone), pharmacological antagonists (novodrin, alupent, isoprenaline), and the cardiotonic agent dobutamine enabled acute heart failure to be effectively treated, hemosorption to be made in early periods and cardiac events to be abolished in 80% of the patients, SCA mortality rates decreased from 11.7 to 3.2%." Order ALL the reference details at left...
5.	Tremor (Tremors) 03/01/1986 - "Oral metaproterenol was associated with a small but significant increase in pulse rate and systolic blood pressure, and a small incidence of unpleasant sensations such as tremor and palpitation. " 08/01/1982 - "No serious adverse effects were seen with either medication, but tremor occurred more frequently with metaproterenol (P less than 0.01). " 01/01/1990 - "No increase in undesirable side effects (eg, nausea, tremor, palpitations) was seen in the metaproterenol-treated group. " 10/01/1982 - "When the 60- and 120-min responses were averaged, tremor response to terbutaline was significantly greater than that to metaproterenol in a 5 : 4 ratio. " 01/01/1980 - "Because finger tremor seems to be due to beta 2-stimulation and palpitation seems to be due to beta 1-stimulation, fenoterol was supposed to be more beta 2-selective than orciprenaline. " Order ALL the reference details at left...

Related Drugs and Biologics

1.	Metaproterenol (Alupent)
2.	Epinephrine (Adrenaline)
3.	Theophylline (Theon)
4.	Ipratropium (Ipratropium Bromide)
5.	Adrenergic beta-Agonists (beta-Adrenergic Agonists)
6.	Cromolyn Sodium (Cromoglicic Acid)
7.	Aminophylline (Carine)
8.	Glycopyrrolate (Glycopyrronium Bromide)
9.	Albuterol (Salbutamol)
10.	Isoproterenol (Isoprenaline)

Related Therapies and Procedures

1.	Metered Dose Inhalers (Metered Dose Inhaler)
2.	Intravenous Infusions
3.	Resuscitation
4.	Hemoperfusion
5.	Oral Administration

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