Mycosis Fungoides

A chronic, malignant T-cell lymphoma of the skin. In the late stages, the LYMPH NODES and viscera are affected.

Networked: 2337 relevant articles (196 outcomes, 221 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1.	Neoplasms (Cancer)
2.	Cutaneous T-Cell Lymphoma (Lymphoma, T Cell, Cutaneous)
3.	Sezary Syndrome (Sezary Erythroderma)
4.	Psoriasis (Pustulosis Palmaris et Plantaris)
5.	Lichen Planus (Lichen Ruber Planus)

Experts

1.	Duvic, Madeleine: 71 articles (05/2022 - 01/2002)
2.	Kim, Youn H: 32 articles (07/2022 - 01/2003)
3.	Guitart, Joan: 23 articles (07/2022 - 10/2002)
4.	Querfeld, Christiane: 23 articles (07/2022 - 07/2004)
5.	Rook, Alain H: 21 articles (01/2022 - 03/2004)
6.	Hodak, Emmilia: 19 articles (07/2022 - 01/2003)
7.	Sugaya, Makoto: 17 articles (02/2022 - 01/2003)
8.	Bagot, Martine: 17 articles (01/2022 - 09/2005)
9.	Kim, Ellen J: 16 articles (05/2022 - 04/2008)
10.	Akilov, Oleg E: 15 articles (05/2022 - 11/2016)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Mycosis Fungoides:

1.	Bexarotene (LGD1069)FDA Link 01/01/2022 - "Complete remission with bexarotene gel in unilesional folliculotropic mycosis fungoides located on the scalp." 05/01/2019 - "Early-stage mycosis fungoides (MF) has been effectively treated with bexarotene, an RXR-agonist, with overall response (OR) rates 54-67% and complete response (CR) rates 7-27%. " 03/01/2003 - "Topical bexarotene is a novel synthetic rexinoid with few side-effects that has shown efficacy for treatment of mycosis fungoides skin lesions in recent Phase II-III clinical trials. " 01/01/2008 - "Safety and efficacy of low-dose bexarotene and PUVA in the treatment of patients with mycosis fungoides." 09/01/2012 - "EORTC 21011 (NCT 00056056) was a randomized phase III study comparing combined bexarotene (Targretin(®) ) and PUVA vs. PUVA alone in patients with stage IB and IIA mycosis fungoides (MF). "
2.	Ficusin (Psoralen)IBA 07/01/2003 - "The influence of psoralen + ultraviolet A treatment on the duration of remission and prognosis in mycosis fungoides." 08/01/2014 - "The purpose of this study was to compare the efficacy and safety of narrow-band UVB and psoralen plus ultraviolet A (PUVA) photochemoterapy in 24 patients with early-stage MF, and explore a new approach for the treatment of early mycosis fungoides. " 09/01/2021 - "Narrow-band-ultraviolet B and psoralen and ultraviolet A are effective treatment options for early-stage mycosis fungoides. " 01/01/2020 - "Background: Little is known about psychological discomfort and quality of life (QoL) in early stage mycosis fungoides (MF) and the effect of psoralen plus UV-A (PUVA) on it. " 01/01/2019 - "Evaluation of Low-Dose, Low-Frequency Oral Psoralen-UV-A Treatment With or Without Maintenance on Early-Stage Mycosis Fungoides: A Randomized Clinical Trial."
3.	Mechlorethamine (Nitrogen Mustard)FDA Link 05/01/2021 - "This real-world study confirmed that chlormethine gel is an important therapeutic option for patients with mycosis fungoides and contributes to reducing the severity of skin lesions and improving health-related quality of life." 10/01/2022 - "Chlormethine gel is effective for the treatment of skin lesions in patients with early- and late-stage mycosis fungoides in clinical practice." 06/09/2022 - "This study shows that chlormethine gel is effective and safe in patients with mycosis fungoides with different types of skin lesions." 01/01/2013 - "The use of a novel mechlorethamine, 0.02%, gel in the treatment of patients with mycosis fungoides is effective and safe. " 01/01/1983 - "Remission of lesions in mycosis fungoides following topical application of nitrogen mustard. "
4.	Interferon-alpha (Interferon Alfa)IBA 04/01/2007 - "Interferon-alpha is effective for CD4(+), CCR4(-) mycosis fungoides." 04/01/1987 - "This study was designed to evaluate the efficacy and tolerability of recombinant leukocyte interferon alfa-2a (Hoffmann-LaRoche) as single agent in patients with histologically confirmed Mycosis Fungoides. " 05/01/2007 - "Eight patients with 29 lesions of histologically verified 1st stage of Mycosis fungoides were successfully treated by electrochemotherapy with interferon-alpha. " 05/01/2007 - "Electrochemotherapy of Mycosis fungoides by interferon-alpha." 01/01/2007 - "Does adjuvant alpha-interferon improve outcome when combined with total skin irradiation for mycosis fungoides?"
5.	Methotrexate (Mexate)FDA LinkGeneric 01/01/2003 - "Mycosis fungoides restricted to the palms: efficacy of methotrexate." 02/05/2021 - "Low-dose methotrexate is widely used in mycosis fungoides and Sézary syndrome, but few studies have evaluated this treatment. " 02/05/2021 - "Overall, the benefit/risk ratio of low-dose methotrexate in mycosis fungoides and Sézary syndrome appears favorable and this treat-ment remains a valid option in mycosis fungoides/Sézary syndrome. " 02/05/2021 - "A retrospective survey of a series of patients treated for mycosis fungoides or Sézary syndrome with low-dose methotrexate and followed for at least one year in a tertiary referral centre was performed. " 02/05/2021 - "Benefit/risk Ratio of Low-dose Methotrexate in Cutaneous Lesions of Mycosis Fungoides and Sézary Syndrome."
6.	Interferon alpha-2 (Roferon-A)FDA Link 06/01/1987 - "A two-part clinical trial was conducted to determine the therapeutic efficacy of recombinant interferon alfa-2b in plaque-phase mycosis fungoides. " 01/01/1990 - "We previously demonstrated that recombinant interferon alfa-2a (IFN-alfa) in a dose of 50 X 10(6) U million units (MU)/m2 intramuscularly (IM) three times per week has efficacy against mycosis fungoides (MF) and the Sézary syndrome (SS). " 01/01/1990 - "Phase II trial of intermittent high-dose recombinant interferon alfa-2a in mycosis fungoides and the Sézary syndrome." 06/01/1987 - "Recombinant interferon alfa-2b in plaque-phase mycosis fungoides. " 12/01/2019 - "We report on an unusual case of a patient with mycosis fungoides with cerebral involvement, in which a durable complete remission was achieved upon autologous stem cell therapy and interferon alfa-2a maintenance therapy."
7.	InterferonsIBA 02/01/2005 - "Systemic interferon is effective in the treatment of mycosis fungoides (MF). " 03/01/2011 - " The combination of PUVA with variable doses of systemically administered interferon α2b (IFN-α2b) reduces the number of PUVA treatments and the dose of IFN-α2b required to produce remission in all mycosis fungoides (MF) stages. " 01/01/2014 - "A multisite, open-label, non-randomized, single-arm phase II study was conducted to evaluate the efficacy and safety profiles of interferon-γ in Japanese patients diagnosed with stage IA-IIIA mycosis fungoides (MF). " 12/28/2012 - "Pharmacokinetic and pharmacodynamic characterization of a new formulation containing synergistic proportions of interferons alpha-2b and gamma (HeberPAG) in patients with mycosis fungoides: an open-label trial." 07/01/2022 - "Interferon α-induced lupus-like reaction in a mycosis fungoides patient: A case report."
8.	Brentuximab VedotinIBA 01/01/2019 - "Dramatic response to brentuximab vedotin in refractory nontransformed CD30- mycosis fungoides allowing allogeneic stem cell transplant and long-term complete remission." 11/01/2021 - "Multicentric EORTC retrospective study shows efficacy of brentuximab vedotin in patients who have mycosis fungoides and Sézary syndrome with variable CD30 positivity." 11/10/2015 - "Phase II Investigator-Initiated Study of Brentuximab Vedotin in Mycosis Fungoides and Sézary Syndrome With Variable CD30 Expression Level: A Multi-Institution Collaborative Project." 01/01/2022 - "Treatment of mycosis fungoides with brentuximab vedotin: Assessing CD30 expression by immunohistochemistry and quantitative real-time polymerase chain reaction." 01/01/2021 - "Response to brentuximab vedotin versus physician's choice by CD30 expression and large cell transformation status in patients with mycosis fungoides: An ALCANZA sub-analysis."
9.	Carmustine (FIVB)FDA Link 09/01/1994 - "Topical BCNU is an effective treatment for patch/plaque stage mycosis fungoides." 01/01/2017 - "Evaluation of O6-Benzylguanine-Potentiated Topical Carmustine for Mycosis Fungoides: A Phase 1-2 Clinical Trial." 01/01/2003 - "The University of California, San Francisco (UCSF), experience with topical carmustine (BCNU) in the treatment of approximately 200 patients with mycosis fungoides (MF) is summarized. " 01/01/2003 - "Topical carmustine (BCNU) in the treatment of mycosis fungoides." 09/01/1994 - "Topical carmustine (BCNU) for patch/plaque mycosis fungoides."
10.	Imiquimod (Aldara)FDA LinkGeneric 01/01/2003 - "Imiquimod induces complete clearance of a PUVA-resistant plaque in mycosis fungoides." 01/01/2005 - "In the present study, we tested the efficacy of imiquimod in mycosis fungoides plaques." 01/01/2005 - "Efficacy of imiquimod in solitary plaques of mycosis fungoides." 12/01/2019 - "Revisiting Imiquimod for Treatment of Folliculotropic Mycosis Fungoides: A Case Report and Review of the Literature." 01/01/2016 - "The article discusses imiquimod treatment for refractory early stage mycosis fungoides, with a review of the literature and three case studies. "

Therapies and Procedures

1.	Therapeutics 11/15/2011 - "Total skin electron beam therapy (TSEBT) is a highly effective treatment for mycosis fungoides (MF). " 01/01/1977 - "The most effective treatment of late mycosis fungoides is total skin electron beam therapy. " 06/01/2019 - "Potential of narrow-band ultraviolet B to induce sustained durable complete remission off-therapy in patients with stage I mycosis fungoides." 07/15/2008 - "Low-dose total skin electron beam therapy can induce complete and partial responses in Stage IB-II mycosis fungoides; however, the duration of remission is short. " 05/01/2007 - "We consider that UVB1 therapy is a good alternative for treatment of early stage mycosis fungoides, although the disease-free period is short."
2.	Phototherapy (Light Therapy) 10/01/2012 - "UVA1 phototherapy was found to induce marked improvement in skin lesions of patients with stages IA and IB mycosis fungoides (MF). " 10/01/2017 - "High-frequency ultrasonography in objective evaluation of the efficacy of PUVA and UVA 1 phototherapy in mycosis fungoides." 08/01/2017 - "A 65-year-old patient affected by mycosis fungoides (MF) stage IB achieved complete remission (CR) after a cycle of PUVA phototherapy. " 08/01/2005 - "Narrowband ultraviolet B (UVB) phototherapy for early-stage mycosis fungoides (MF) has been found to be beneficial in some reports. " 01/01/2005 - "No significant differences were found regarding the risk of developing mycosis fungoides or the tendency to remission in patients treated with or without phototherapy. "
3.	Photochemotherapy (Photodynamic Therapy) 02/01/2023 - "Efficacy of textile photodynamic therapy for mycosis fungoides." 01/01/1987 - "[Photochemotherapy of patients with mycosis fungoides: a clinico-histomorphological study]." 01/01/1981 - "Photochemotherapy (PUVA) in the tumour stage of mycosis fungoides: a report from the Scandinavian Mycosis Fungoides Study Group." 01/01/1981 - "Photochemotherapy (PUVA) in the pretumour stage of mycosis fungoides: a report from the Scandinavian Mycosis Fungoides Study Group." 07/01/1979 - "Photochemotherapy in mycosis fungoides--a study of fifty-six patients [proceedings]."
4.	Radiotherapy 11/01/2017 - "Total skin electron beam radiation therapy (TSEB) is a very effective treatment of mycosis fungoides. " 01/01/2020 - "Radiotherapy Eradicates Malignant T Cells and Is Associated with Improved Survival in Early-Stage Mycosis Fungoides." 04/01/2019 - "Efficacy of low-dose radiotherapy for refractory mycosis fungoides of the face." 09/01/1998 - "Unilesional mycosis fungoides has a long natural history, is possibly the earliest manifestation of a malignant process, and local treatments, including local radiotherapy, result in long-term disease-free intervals and, possibly, cure. " 08/01/1989 - "Combined total body X-ray irradiation and total skin electron beam radiotherapy with an improved technique for mycosis fungoides."
5.	Drug Therapy (Chemotherapy) 11/01/1979 - "Topical chemotherapy is effective in early stages of mycosis fungoides. " 09/01/2017 - "For patients with advanced CTCL eligible for HSCT, autologous HSCT was performed when they responded well to chemotherapy, and allogeneic HSCT was selected for patients with advanced mycosis fungoides (MF)/Sézary syndrome (SS) and CTCL other than MF/SS with poor chemosensitivity. " 01/01/1983 - "We have presented a study of two cases of Mycosis Fungoides with special emphasis on the staging of the disease as well as on the immunological findings and their modification with chemotherapy. " 01/01/1979 - "The Scandinavian Mycosis Fungoides Study Group have treated 19 patients with mycosis fungoides in tumour stage by systemic chemotherapy. " 06/01/2020 - "The mycosis fungoides lesion exacerbated after 3 months;thus, chemotherapies were performed. "